Association of the IL-6R gene polymorphic variant rs2228145(C>A) with IL-6 gene polymorphisms in a healthy cohort of Turkish population Research Published on 2022-04-012022-10-05 Journal: Genes and Immunity [Category] 바이오마커, 유전자 메커니즘, [키워드] age allele allele G allelic association Bilirubin BMI body mass index Cohort collected Comorbidity Concentration Diseases evaluated explained fasting insulin Folic acid Frequency Gender Globulin healthy hematological parameters hormone IL-6 IL-6R IL-6R gene individuals Laboratory laboratory data laboratory parameter Liver function test loci locus majority monocyte neutrophil Platelets polymorphic variant polymorphism renal rs2228145 SHBG significantly higher significantly lower subject uric acid variant Variation White blood cells [DOI] 10.1038/s41435-022-00167-7 [Article Type] Research
QCovSML: A reliable COVID-19 detection system using CBC biomarkers by a stacking machine learning modelResearch article Published on 2022-04-012022-10-05 Journal: Computers in biology and medicine [Category] 바이오마커, 치료기술, [키워드] Accuracy age approach AUC average Biomarker blood cell count CBC Cohort collected complete blood count Complete blood count (CBC) coronavirus disease country COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 patients cut-off value dataset datasets demonstrated detection detection system equipment evaluate external validation false-negative rate FIVE Generalizability gold standard Hospital admission Italy less lymphocyte machine learning classifiers monocyte parameter Patient positive Precision predict produced Raphael robust RT-PCR scoring system sensitivity Seven specificity Stacking machine learning the patient was used were used white [DOI] 10.1016/j.compbiomed.2022.105284 [Article Type] Research article
SARS-CoV-2 infection in dialysis and kidney transplant patients: immunological and serological response투석 및 신장 이식 환자의 SARS-CoV-2 감염: 면역학적 및 혈청학적 반응Article Published on 2022-04-012022-09-11 Journal: Journal of Nephrology [Category] COVID19(2023년), SARS, 치료법, [키워드] alteration anti-spike antibodies anti-spike antibody anti-spike antibody response B cells B-cell baseline baseline characteristics CD4 CD8 chemokine chemokines controls COVID-19 cytokine Cytokines DCs dendritic cell dialysis expression groups healthy subject healthy subjects Hemodialysis high mortality rate Hospitalization IFN-α IL10 IL6 immunological immunology innate immune system involved kidney transplant kidney transplant recipient kidney transplant recipients lymphocyte Lymphocyte subsets Lymphocytes moderate-severe monocyte Monocyte activation monocyte HLA-DR neutrophil neutrophil recruitment Patient patients patients with COVID-19 populations proportion SARS-CoV-2 SARS-COV-2 infection serological response severe disease symptom onset T cells terminally differentiated the disease two groups uninfected was increased were measured [DOI] 10.1007/s40620-021-01214-8 PMC 바로가기 [Article Type] Article
The anti-C5a antibody vilobelimab efficiently inhibits C5a in patients with severe COVID-19항-C5a 항체 빌로벨리맙은 중증 COVID-19 환자에서 C5a를 효율적으로 억제합니다Article Published on 2022-04-012022-09-11 Journal: Clinical and translational science [Category] 임상, 진단, [키워드] 1:1 Activation adaptive Analysis anaphylatoxin C5a antibody assigned benefit best Blood C3a C5a cause Chain Reaction Coagulation Coagulation system Concentration control group coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia demonstrated drug concentration enzyme favor geometric geometric mean IFX-1 Infection infection site inhibit IQR leads median monoclonal antibody monocyte Monocytes neutrophil Neutrophils oxidative Patient plasma polymerase chain polymerase chain reaction Randomly ranged real-time polymerase chain reaction receive releases reported Result Safe Sample secondary outcome severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia supportive care suppressed suppression tissue damage Trial vilobelimab [DOI] 10.1111/cts.13213 PMC 바로가기 [Article Type] Article
DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonistsDAMP/PAMP는 COVID-19 환자에서 단핵구 TLR 활성화 및 내성을 유도합니다. 핵산 결합 스캐빈저는 이러한 TLR 작용제에 대항할 수 있습니다.Article Published on 2022-04-012022-09-12 Journal: Biomaterials [Category] COVID19(2023년), SARS, 진단, [키워드] Activation agonist anti-viral response binding Blood CD16 COVID-19 COVID-19 patient COVID-19 patients damage Deceased Ex vivo hallmark hyperactivate Hyperactivation hyperinflammation Hyperstimulation ICU ICU patient immunopathology induce Infection Inflammation innate immune intensive care unit limit lung Lungs Major-biological sciences Minor-immunology and inflammation. monocyte Monocytes neutralize nucleic acid outcome patients pattern phenotype proteomics receptors RNA-sequencing SARS-CoV-2 Signaling systemic inflammation the patient TLR TLR agonist TLR stimulation Tolerance Toll-like receptor Treatment viruses [DOI] 10.1016/j.biomaterials.2022.121393 PMC 바로가기 [Article Type] Article
The S1 Subunit of the SARS-CoV-2 Spike Protein Activates Human Monocytes to Produce Cytokines Linked to COVID-19: Relevance to Galectin-3SARS-CoV-2 스파이크 단백질의 S1 서브유닛은 인간 단핵구를 활성화하여 COVID-19와 연결된 사이토카인을 생성합니다: 갈렉틴-3과의 관련성Article Published on 2022-03-222022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] ACE2 activate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ARDS basophil basophils bind caused component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRS cytokine Cytokine release syndrome Cytokines dendritic dendritic cell disease dysregulated Efficacy epithelial cell epithelial cells Evidence facilitate feature fold galectin-3 Health human monocyte human monocytes immune cells Inflammation innate immune innate immune cell Innate immune cells innate immune response Innate immunity lectin Lung injury mechanism MERS Middle East Middle East respiratory syndrome monocyte Monocytes N-terminal domain novel vaccines NTD pandemic persistence pocket Produce Relevance reported respiratory respiratory distress Respiratory distress syndrome responsible S1 subunit S1-NTD S2 subunit SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus shown solid phase spike Spike protein stalk structural homology susceptible individuals syndrome synthesis the S1 subunit the SARS-CoV-2 the spike protein therapeutic interventions Therapeutics Vaccine variants virus while β-Coronaviruses [DOI] 10.3389/fimmu.2022.831763 PMC 바로가기 [Article Type] Article
SARS-2 COVID-19-induced immunity response, a new prognostic marker for the pregnant population correlates inversely with neonatal Apgar scoreOriginal Paper Published on 2022-03-052022-10-29 Journal: Infection [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] accompanied Admission APGAR score appear association Biomarkers clinician collected Complication complications correlated COVID-19 COVID-19 infection COVID-19 patient defined distress exhibited facilitate haematological parameter Haematology help Hypothesis hypothesised immune response Immunity impacted Intensive Intervention Laboratory monocyte mother Neonatal Neonate neutrophil non-pregnant females outcome outcomes Patient perinatal health populations predict Pregnancy pregnant pregnant female pregnant females pregnant patient pregnant patients pregnant population prevalent Prognosis Prognostic marker PROTECT reduce response Result significantly significantly lower subject tested WBC [DOI] 10.1007/s15010-022-01773-3 PMC 바로가기 [Article Type] Original Paper
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infectionArticle Published on 2022-02-232022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 임상, 치료기술, [키워드] airway antiviral immune response approach characterized circulating COVID-19 immune Immune cell immune response immune signature Immunological response Immunomodulatory therapies implication Infection Inflammatory diseases interferon ISG limit Local monocyte natural Patient phenotype Prevent Prognosis progressive disease Protective protective immunity reduced resolved SARS-CoV-2 SARS-CoV-2 infected patient SARS-COV-2 infection SARS-CoV2 infection stimulated subset systemic inflammatory T cells trajectory upper airway upper respiratory upregulation viral infection viral spread [DOI] 10.1038/s41467-022-28508-0 PMC 바로가기 [Article Type] Article
Identification of Distinct Immune Cell Subsets Associated With Asymptomatic Infection, Disease Severity, and Viral Persistence in COVID-19 PatientsImmunology Published on 2022-02-222022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Analysis Apoptosis asymptomatic infection asymptomatic subject CD14 CD160 CD33 CD68 CD8 Cell CLEC10A clinical presentation comprehensive analysis COVID-19 CSF1R develop Differentially expressed genes disease severity ENhance enriched pathway help HLA-DMA identification IL1B immune response immune responses Immunopathogenesis Inflammation KEGG LAG3 monocyte NCAM1 pathogenic PBMC positively correlated Protective S100A9 SARS-CoV-2 SARS-COV-2 infection scRNA-seq severity significantly singlecell RNA sequencing (scRNA-seq) subset surface marker Symptomatic patients the disease TRAV1-2 unique viral persistence [DOI] 10.3389/fimmu.2022.812514 PMC 바로가기 [Article Type] Immunology
Increased Interleukin 18-Dependent Immune Responses Are Associated With Myopericarditis After COVID-19 mRNA Vaccination증가된 인터루킨 18 의존성 면역 반응은 COVID-19 mRNA 백신 접종 후 심근염과 관련이 있습니다Immunology Published on 2022-02-182022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] abnormality activated Activation administration Cardiac complications caused CD68 Cell characterized chest pain circulating Control controls COVID-19 COVID-19 mRNA Vaccination COVID-19 mRNA vaccine COVID-19 vaccination cytokine Cytokines disease onset dysfunction elevated expressed first dose Flow cytometry analysis healthy individual hearts IL-18 IL-27 Immune profile immune response incidence Increased individuals infiltration interleukin interleukin 18 mechanism mice Mild monocyte mRNA mRNA-1273 COVID-19 vaccine multiplex Myopericarditis NK cell NK cells NLRP3 inflammasome occur Patient phenotype progression response T cell Th1-type immune response the patient troponin I upstream vaccinated individual vaccination were used with COVID-19 [DOI] 10.3389/fimmu.2022.851620 PMC 바로가기 [Article Type] Immunology