multiorgan failure – Page 9 – Communicable Diseases Research

Investigation of Genetic Variations of IL6 and IL6R as Potential Prognostic and Pharmacogenetics Biomarkers: Implications for COVID-19 and Neuroinflammatory Disorders

Communication

Published on 2020-12-162022-10-29
Journal: International Review of Cell and Molecular Biology [Category] COVID-19,

Coagulation abnormalities in SARS-CoV-2 infection: overexpression tissue factor

Review

Published on 2020-12-152022-10-29
Journal: Thrombosis Journal [Category] COVID-19,

[키워드] abnormality Activation addition alveolar cells angiotensin converting enzyme Angiotensin II Apoptosis bind Cell coagulation cascade Coagulation system Coagulopathy complex Complication COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients Critical Cytokine storms death dysregulated enzyme expression Factor Hemostasis IL-1β IL-6 increased risk induce infect Inflammatory cytokine inhibitor involved life-threatening lymphocyte macrophages monocytes/macrophages Mortality multiorgan failure Myocardial infarction occur overexpression pathway patients platelet activation Platelets Proinflammatory cytokine proinflammatory cytokines receptor reduce risk S protein SARS-CoV-2 stroke surface the cytokine storm these cell Thromboembolism thrombosis tissue Tissue Factor TLR TNF-α transmembrane viral infection viral infections
[DOI] 10.1186/s12959-020-00250-x PMC 바로가기 [Article Type] Review

Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study

Observational Study

Published on 2020-12-012022-10-04
Journal: The Lancet. Respiratory Medicine [Category] Coronavirus, Fulltext, MERS, 임상,

[키워드] acute respiratory distress analysed ARDS baseline calculate cause Classifier Cohort collected Concentration COVID-19 COVID-19-associated ARDS Critically ill patient Cutoff demographic described died eight Exploratory analysis FIVE Health Hyperinflammatory identify IL-6 inflammatory pathway inspired air intensive care units interleukin-6 IQR laboratory data median Mortality multicentre multiorgan failure Necrosis Older oxygen PaO Patient patients patients with ARDS phenotype Phenotypes point-of-care Prevalence Probability proportion prospective observational study randomised controlled trial receptor recruited severity significantly lower Survivors syndrome systemic inflammation TNFR1 unlikely upregulation was used
[DOI] 10.1016/S2213-2600(20)30366-0 PMC 바로가기 [Article Type] Observational Study

The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19)

Article

Published on 2020-11-122022-10-29
Journal: Scientific Reports [Category] COVID-19,

[키워드] ACE2 activate acute respiratory distress acute respiratory syndrome angiotensin-converting enzyme 2 approach ARDS Asymptomatic cause Clinical sign common cold coronavirus COVID-19 death demonstrated disease Extracellular extrapulmonary tissues functional highly pathogenic Host human neutrophils indicated individual Infection investigated lymphocyte majority microthrombus multiorgan failure NETosis NETs neutrophil Neutrophil extracellular trap Neutrophils novel coronavirus SARS-CoV-2 pathway patients with comorbidity pro-inflammatory cytokine receptor ROS SARS-CoV-2 shown Specy stimulate symptomatic syndrome target cells the patient therapy thrombosis tissue upregulation viral infection Viral load virus entry
[DOI] 10.1038/s41598-020-76781-0 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Infection and Cardioncology: From Cardiometabolic Risk Factors to Outcomes in Cancer Patients

Review

Published on 2020-11-102022-10-31
Journal: Cancers [Category] COVID-19,

[키워드] active cancer acute respiratory distress addition angiotensin-converting enzyme 2 Anticancer therapy arrhythmia Cancer cancer patient Cancer patients cardiac event cardiac myocytes cardioncology cardiovascular disease cardiovascular diseases Cardiovascular events caused changed Chemotherapy clinical study Coagulation coagulative Comorbidity complications of COVID-19 Contamination coronavirus COVID-19 Cytokines cytotoxic T lymphocytes death defined diabetes Diseases Effect exacerbated expressed Factor gastro-intestinal tract healthy high risk higher risk highlight Hyperactivation Hyperinflammatory hypertension Inflammation interact Lungs macrophages magnitude management morbidity Mortality Multiorgan multiorgan failure myocardial injury myocarditis Natural killer cells outcome pandemic Patient patients Perspective Prognosis Radiotherapy recommendation reduce retrospective risk risk factor risk reduction SARS-CoV-2 SARS-COV-2 infection secondary hemophagocytic lymphohistiocytosis serine protease sHLH Side effect significantly simple syndrome therapy TMPRSS2 Transmission treated Treatment Venous Thromboembolism viral infection vulnerable patients with COVID-19 World Health Organization
[DOI] 10.3390/cancers12113316 PMC 바로가기 [Article Type] Review

Clinical characteristics of 10 children with a pediatric inflammatory multisystem syndrome associated with COVID-19 in Iran

Research Article

Published on 2020-11-092022-10-28
Journal: BMC Pediatrics [Category] COVID-19, SARS,

[키워드] abdominal pain Adults age analyzed Anemia Appendicitis association C-reactive protein Case report Characteristics Chest computed tomography children clinical Clinical characteristics coronary aneurysm Coronavirus disease 2019 cough COVID-19 defined demographic diagnosed diarrhea died discharged edema elevated erythrocyte sedimentation rate febrile Fever Gastrointestinal symptom Giant Hemorrhagic hospital infancy Infection Inflammatory Iran Kawasaki disease Laboratory lymphopenia MOST multiorgan failure myocarditis pediatric Pediatric Inflammatory Multisystem Syndrome PIMS Pneumonia polymerase chain positive Rash Result SARI Seizure Sepsis Serologically Severe case Shock Symptom syndrome tachypnea the patient therapeutic vomiting were recorded with COVID-19
[DOI] 10.1186/s12887-020-02415-z PMC 바로가기 [Article Type] Research Article

Association of Troponin Levels With Mortality in Italian Patients Hospitalized With Coronavirus Disease 2019: Results of a Multicenter Study

2019년 코로나바이러스 질병으로 입원한 이탈리아 환자의 사망률과 트로포닌 수치의 연관성: 다기관 연구 결과

Multicenter Study

Published on 2020-11-012022-09-11
Journal: JAMA Cardiology [Category] Fulltext, SARS, 치료기술,

[키워드] Acute coronary syndrome acute kidney failure Admission age Analysis Atrial fibrillation bleeding cardiac disease cardiac troponin Characteristics Chinese clinical Clinical characteristics Comorbidity Complication consecutive patient consecutive patients Coronary artery Coronary artery disease coronary syndrome coronavirus disease Coronavirus disease 2019 COVID-19 cross-sectional cross-sectional study defined delirium died elevated European evaluate greater heart failure higher risk Hospitalization Hospitalized hypertension In-hospital in-hospital complications in-hospital mortality independent independent variable initial Injury Italian Italian patient Italian patients Kidney failure laboratory-confirmed Laboratory-confirmed COVID-19 Level major bleeding male Mortality mortality rates multicenter multicenter study multiorgan failure multivariable Cox regression myocardial injury normal values Older outcome Patient patients patients hospitalized patients with COVID-19 plasma populations Prevalence Prognostic value Pulmonary embolism reported Result risk Sepsis single-center stratified troponin troponin I troponin level troponin levels troponin T were excluded white with COVID-19
[DOI] 10.1001/jamacardio.2020.3538 PMC 바로가기 [Article Type] Multicenter Study

Pirfenidone: A novel hypothetical treatment for COVID-19

피르페니돈: COVID-19에 대한 새로운 가상 치료제

Article

Published on 2020-11-012022-08-31
Journal: Medical Hypotheses [Category] 신약개발, 유전자 메커니즘, 치료법,

[키워드] ACE acute respiratory distress acute respiratory distress syndrome adverse effects angiotensin angiotensin converting enzyme Angiotensin converting enzyme receptor Apoptosis approved ARDS Cell COVID-19 COVID-19 patients cytokine Cytokine storm decrease distress downregulate expression fibrosis hypothetical idiopathic Idiopathic pulmonary fibrosis Inflammation inhibit Invasion IPF kill majority mechanism mechanism of action Mild mild to moderate mild to moderate disease moderate disease morbidity Mortality multiorgan failure oxidative stress pathophysiology Patient patients with COVID-19 Pirfenidone pneumocyte Pneumocytes PROTECT pulmonary pyridone receptor respiratory distress Respiratory distress syndrome syndrome Treatment treatment for COVID-19 treatment of COVID-19 patients
[DOI] 10.1016/j.mehy.2020.110005 PMC 바로가기 [Article Type] Article

NLRP3 Inflammasome: The Stormy Link Between Obesity and COVID-19

NLRP3 Inflammasome: 비만과 COVID-19 사이의 폭풍우 연결

Review

Published on 2020-10-302022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] accelerate Activation addition Cancer cause Cell cell death coronavirus disease Coronavirus disease 2019 country COVID-19 cytokine Cytokine release syndrome Cytokine storm Cytokines death diabetes disease dyslipidemia H1N1 H1N1 influenza HIV hypertension hypertriglyceridemia immune response individual induce infections Inflammasome Influenza leads metabolic syndrome molecular mechanism molecular mechanisms multifactorial multiorgan failure multiple comorbidities multiple comorbidity NLRP3 NLRP3 inflammasome obesity obesogenic Osteoarthritis pandemic pro-inflammatory cytokine pro-inflammatory cytokines provide pyroptosis responsible SARS-CoV-2 SARS-COV-2 infection secretion severe acute respiratory syndrome coronavirus 2 syndrome systemic inflammation systemic inflammatory triggering type 2 diabetes virus viruses
[DOI] 10.3389/fimmu.2020.570251 PMC 바로가기 [Article Type] Review

Managing the combined consequences of COVID-19 infection and lock-down policies on athletes: narrative review and guidelines proposal for a safe return to sport

Review

Published on 2020-10-192022-10-27
Journal: BMJ Open Sport — Exercise Medicine [Category] COVID-19,

[키워드] affected appear approach biological profile cardiac complication Cardiology Cardiovascular disorders clinical manifestation Community consequence cough COVID-19 COVID-19 infection COVID-19 pandemic diabete disease spread Dyspnoea evaluate exercise fatigue Fever globe headache Health hypertension hypoxaemia individual individuals managing Medical conditions MONITOR multiorgan failure myalgia myocarditis occur physical ability Physiology Postinfection reduce reported respiratory Respiratory failure risk Safe severe cases Shock sore throat sports & exercise medicine stoppage Symptom Symptoms symptoms of COVID-19 the disease
[DOI] 10.1136/bmjsem-2020-000849 PMC 바로가기 [Article Type] Review