Alpha/Beta Interferon (IFN-α/β) Signaling in Astrocytes Mediates Protection against Viral Encephalomyelitis and Regulates IFN-γ-Dependent ResponsesCellular Response to Infection Published on 2018-02-282022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] Ablation adaptive affected Antiviral Astrocyte astrocytes Cell Central nervous system CNS components contribute coronavirus Critical dissemination effective elevated elicit Encephalomyelitis evaluated expression function Gene Expression Glia histocompatibility complex IFN-α IFN-β IFN-α/β IFN-γ IFNAR immune Immunity inducer Infection infiltration initial Innate immunity Interaction interferon interferon-stimulated gene ISG ISGs lack lethal MHC MHV mice microglia Mortality mouse hepatitis virus mRNA mRNA level Neuron neurons pathway pattern recognition receptor promote PROTECT protection Protective PRRs receptor reduced Regulatory response responses robust Signaling Single Cell subsequent Support supported sustained T cell upregulated viral infection viral spread virus virus replication virus spread while [DOI] 10.1128/JVI.01901-17 PMC 바로가기 [Article Type] Cellular Response to Infection
Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALSRetrotransposon 활성화는 ALS의 Drosophila TDP-43 모델에서 신경 퇴행에 기여합니다Research Article Published on 2017-03-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abnormality accompanied Activation aggregation ALS Amyotrophic lateral sclerosis Author cascade cause cell death cell types cells Characteristics contribute cytoplasmic de-repression death degeneration degenerative disease DNA DNA binding protein DNA damage Drosophila Effect Effects element event Evidence expressed expression Familial Genetic Genome Glia glial cells hallmark human disease impair impairment Inclusion incurable inhibiting Lateral Sclerosis lobar locomotor LTR majority mechanism Mutation neurodegeneration neurodegenerative disorder neurodegenerative disorders Neuron neuronal neurons nuclear protein pathology pathophysiological phenotype phenotypic Premature programmed cell death PROTECT Protein repression retrotransposon retrotransposons retrovirus reverse transcriptase RNA RNA silencing siRNA Small interfering RNA storm subset the disease tissue Toxicity transcriptase [DOI] 10.1371/journal.pgen.1006635 PMC 바로가기 [Article Type] Research Article
Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 ComplexBeclin 1은 뉴런 생존에 필요하고 UVRAG-VPS34 복합체를 통해 엔도솜 경로를 조절합니다Research Article Published on 2014-10-022022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity addition animal model assembly autophagosome autophagy Beclin 1 Brain cause cell line cellular characterized Complete complex complexes conditions Coordinate deficiency disease Diseases Disruption distribution EEA1 endocytosis endosome Endosomes Evidence failure function Genetic human disease impair impairment implicated in addition to in vivo Infectious disease Interaction involved leads maintain mammalian maturation membrane molecular mechanism mutant neurodegeneration neurodegenerative Neuron neuronal neurons nucleation organelle overexpressed p40 pathway Pathways phosphatidylinositol phosphatidylinositol 3-kinase physiological PI3K Previous studies previous study Protein recent recruit recruitment regulate Regulation required rescued reveal RUBICON survival tumorigenesis UVRAG viability [DOI] 10.1371/journal.pgen.1004626 PMC 바로가기 [Article Type] Research Article
Cell Type-Specific Functions of Period Genes Revealed by Novel Adipocyte and Hepatocyte Circadian Clock Models새로운 지방세포 및 간세포 일주기 시계 모델에 의해 밝혀진 기간 유전자의 세포 유형별 기능Research Article Published on 2014-04-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adipocytes Affect amplitude animals Behavior biochemical Bmal1 Brain Cell cell types cellular circadian clock circadian rhythms CLOCK component Cry1 Cry2 Effect evaluated expected Families feasible fibroblasts function Gene Expression Genes Genetic genomic hepatocyte hepatocytes hypothalamus Impact implication Interaction kinetic knockdown knockout mice lentivirus library Local Luminescence mechanism metabolism microplate reader Model molecular negative feedback negative feedback mechanism neurons novel nuclei Per1 Per2 PER3 Period phenotype Physiology Previous studies regulated reporter reveal Revealed RNA RNA interference small molecule Small molecules tissue specific transcriptional [DOI] 10.1371/journal.pgen.1004244 PMC 바로가기 [Article Type] Research Article
Varicella Zoster Virus (VZV)-Human Neuron InteractionReview Published on 2013-09-042023-05-24 Journal: Viruses [Category] Fulltext, 두창, 수두, 홍역, [키워드] latency neurons Varicella zoster virus [DOI] 10.3390/v5092106 PMC 바로가기 [Article Type] Review
Distinct and Atypical Intrinsic and Extrinsic Cell Death Pathways between Photoreceptor Cell Types upon Specific Ablation of Ranbp2 in Cone Photoreceptors원추형 광수용체에서 Ranbp2의 특정 제거 시 광수용체 세포 유형 간의 고유하고 비정형적인 고유 및 외인성 세포 사멸 경로Research Article Published on 2013-06-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Ablation Activation acute transverse myelitis affecting Apoptosis approaches arise Author base cascade caspase caspase-3 caspase-7 caspase-9 cause Cell cell death clinical manifestations cone cone photoreceptor contribute death degenerate degeneration demise develop Diseases disintegration downstream driving event expression extrinsic Factor followed by found Gene Genes Genetic genetic defect hallmark healthy heterogeneous implicated intrinsic intrinsically manifestation mechanism membrane permeability metalloproteinase modulation molecular mosaic multifunctional protein Mutation Myelitis necrotic neural retina neurodegeneration neurodegenerative neurodegenerative disorders Neuron neurons neuroprotection PARP1 pathway Pathways photoreceptor photoreceptors pleiotropic progression progression of disease promote Protein Ranbp2 rod rod photoreceptor rod photoreceptors rods spatiotemporal Specific Stressor subcellular therapeutic thought transverse myelitis Trigger triggered Tumor Type undergo underlying disease underlying diseases up-regulation [DOI] 10.1371/journal.pgen.1003555 PMC 바로가기 [Article Type] Research Article
The distinct binding properties between avian/human influenza A virus NS1 and Postsynaptic density protein-95 (PSD-95), and inhibition of nitric oxide productionResearch Published on 2011-06-132023-06-07 Journal: Virology Journal [Category] 신종인플루엔자, [키워드] Influenza virus neurons nitric oxide NS1 PSD-95 [DOI] 10.1186/1743-422X-8-298 PMC 바로가기 [Article Type] Research
Pathogenetic mechanisms of severe acute respiratory syndromeArticle Published on 2007-09-072022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] acute respiratory disease acute respiratory syndrome affected angiotensin-converting enzyme 2 autopsy study Brain caused cell type cellular and molecular clinical manifestation contribute Diagnosis digestive tract Direct disease dysfunction enterocytes epithelial cell expressing hypoxia immune cells immune responses immune system implication include Infected Infection Injury kidneys liver lung mechanism morbidity and mortality neurons organ Other Pathogenesis pathological finding pathology pneumocyte primary target cell receptor renal SARS SARS-CoV severe target cell the disease therapy thyroid gland virus while [DOI] 10.1016/j.virusres.2007.01.022 PMC 바로가기 [Article Type] Article