Plasmodium knowlesi: a relevant, versatile experimental malaria modelReview Published on 2018-01-012023-06-21 Journal: Parasitology [Category] 조류인플루엔자, [키워드] in vitro malaria Model non-human primates Plasmodium knowlesi severe malaria transfection Vaccine zoonosis. [DOI] 10.1017/S0031182016002286 PMC 바로가기 [Article Type] Review
Widespread Shortening of 3’ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection3' 번역되지 않은 영역의 광범위한 단축 및 증가된 엑손 포함은 감염에 대한 타고난 면역 반응의 진화적으로 보존된 특징입니다Research Article Published on 2016-09-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3’ UTR accompanied activated adaptive immune responses Bacteria Bacterial infection Bacterial infections cellular response Cellular responses change changes in characterized collected complementary conserved evade example ExoN expression Factor feature functional Gene Expression Gene regulation human macrophage human macrophages idea identify immune immune response immune responses Inclusion increase in Increased individuals Infection Innate innate immune response innate immune responses involved isoform less Listeria monocytogene Listeria monocytogenes Macrophage macrophages mechanism microRNA miRNAs mRNA non-human primates polyadenylation sites Post-infection pre-mRNA primates reduced Region regulate regulated Regulation repression response RNA Salmonella Typhimurium sequenced Sequencing shortening significantly Support tandem transcriptional response transcriptional responses upstream Usage UTRs Variation while whole blood sample [DOI] 10.1371/journal.pgen.1006338 PMC 바로가기 [Article Type] Research Article
Development of Medical Countermeasures to Middle East Respiratory Syndrome CoronavirusOnline Report Published on 2016-07-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] affected animal model animal models antibodies antivirals clinical trial countermeasure country development diagnostics disease disease pathogenesis Efficacy effort evaluate human clinical trials identify include medical countermeasure Medical countermeasures MERS-CoV Middle East Middle East respiratory syndrome Coronavirus monoclonal non-human primates nonhuman primates polyclonal Preclinical protocol Research respiratory respiratory infections respiratory syndrome coronavirus Standardization Support tested Therapeutics vaccination Vaccines virus stock viruses [DOI] 10.3201/eid2207.160022 PMC 바로가기 [Article Type] Online Report
Coronaviruses and the human airway: a universal system for virus-host interaction studiesReview Published on 2016-02-062022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] airway airway epithelium ALI alveolar animal model Antiviral Antiviral compound Antiviral compounds antivirals cell culture system cell lines cell tropism circulation compound toxicity conducted coronavirus CoV Culture determine effective evade HAE highlight Host immune response Human human airway Human airway epithelium human airways Human coronavirus human respiratory tract human respiratory virus humans identify in viral infect Infection Interaction interface involved mechanism mice Middle East Morphological non-human primates Pathogenesis platform Research respiratory RNA virus syndrome the epidemic Treatment Vaccine virus virus [DOI] 10.1186/s12985-016-0479-5 PMC 바로가기 [Article Type] Review
Contact to Non-human Primates and Risk Factors for Zoonotic Disease Emergence in the Taï Region, Côte d’IvoireArticle Published on 2015-12-012023-06-02 Journal: EcoHealth [Category] 조류인플루엔자, [키워드] bushmeat non-human primates sub-Saharan Africa zoonotic pathogen transmission. [DOI] 10.1007/s10393-015-1056-x PMC 바로가기
Evaluation of candidate vaccine approaches for MERS-CoVArticle Published on 2015-07-282022-10-29 Journal: Nature Communications [Category] Coronavirus, MERS, [키워드] Analysis antibodies approach approach atomic candidate vaccine complex Computerized tomography CoV demonstrated DNA effective elicit full-length S glycoprotein highlight immunization immunogen information Isolation mechanism MERS-CoV mice Middle East monoclonal antibody Multiple murine NAb neutralization neutralizing antibody non-human primates Pneumonia Protein Radiographic RBD respiratory syndrome coronavirus responses rhesus macaque robust S variant S1 and S2 S1 subunit Sequencing serological assays severe respiratory disease spike strain subunit supplementary material the receptor-binding domain Vaccine Vaccine development Vaccines viral infection Virology virus [DOI] 10.1038/ncomms8712 PMC 바로가기 [Article Type] Article
Digital Genotyping of Macrosatellites and Multicopy Genes Reveals Novel Biological Functions Associated with Copy Number Variation of Large Tandem RepeatsMacrosatellites 및 Multicopy 유전자의 디지털 유전형 분석은 대규모 직렬 반복의 복사 수 변화와 관련된 새로운 생물학적 기능을 나타냅니다.Research Article Published on 2014-06-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accompanied accumulation accumulations Analysis approach approaches association Biological Biological functions changes in copy copy number correlation Digital DNA methylation DNA methylation levels Effect Effects eukaryotic Evolution example expansion extreme FIVE focus fraction function functional Gene Expression Genes Genome genome assembly Genome-wide association study genomes genomic Genotype GWAS hallmark hallmarks human population human populations humans identify include information lead Local loci majority mechanism modulating non-human primates novel nucleotide number Organisms phenotypic diversity Population Previous studies Repeat repeated selective selective pressure sequence significantly single nucleotide single nucleotide variation SNP SNPs suppression tandem tandem repeat tandem repeats transgenic utility Variability variant variants Variation variations [DOI] 10.1371/journal.pgen.1004418 PMC 바로가기 [Article Type] Research Article
Potential Vaccines and Post-Exposure Treatments for Filovirus InfectionsReview Published on 2012-09-212023-08-29 Journal: Viruses [Category] E형 간염, [키워드] animal models clinical trials Ebola Ebolavirus filovirus Marburg virus marburgvirus non-human primates post-exposure treatments Vaccines [DOI] 10.3390/v4091619 PMC 바로가기 [Article Type] Review