Design and in silico validation of polymerase chain reaction primers to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Article Published on 2021-06-152022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] acute respiratory syndrome analyses Bacterial conserved coronavirus coronavirus 2 demonstrated described detect Diagnostic markers false-negative fungal Genome GISAID in silico in viral initiative less Multiple sequence alignment nine nonspecific pathogenic Pathogens PCR polymerase chain primer probe probe sequence protocol protocols Region respiratory SARS-CoV-2 silico prediction Standardization target virus genome whole-genome sequences [DOI] 10.1038/s41598-021-91817-9 PMC 바로가기 [Article Type] Article
Assay System for Simultaneous Detection of SARS-CoV-2 and Other Respiratory VirusesArticle Published on 2021-06-132022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] acute respiratory syndrome Analysis automated can be used caused comparable coronavirus coronavirus disease detection diagnostic disease Efficiency FIVE help Inc. Infection infections Influenza virus molecular nasopharyngeal swab specimen no significant difference nonspecific nucleic acid extraction Other overlap pandemic Patient platform processed reliability respiratory respiratory infection respiratory syncytial virus respiratory virus RSV SARS-CoV-2 Simultaneous simultaneous detection South Korea statistically Symptom System Trigger viral strain Z-scores [DOI] 10.3390/diagnostics11061084 PMC 바로가기 [Article Type] Article
Can Antiviral Activity of Licorice Help Fight COVID-19 Infection?감초의 항 바이러스 활동이 CovID-19 감염과 싸울 수 있습니까?Review Published on 2021-06-082022-09-10 Journal: Biomolecules [Category] MERS, SARS, 치료제, [키워드] ACE2 activity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-inflammatory antioxidant effect antioxidant effects antiviral properties antiviral property Can can not Cell chymotrypsin clinical trials component components Compound coronavirus COVID-19 COVID-19 disease COVID-19 emergency cysteine cysteine protease docking study enoxolone excluded feature Glycyrrhetinic acid glycyrrhiza glycyrrhizic acid glycyrrhizin Host in viral indicated interfere licorice liquorice membranes nonspecific pandemic pharmacological Replication reported SARS Coronavirus SARS-CoV-2 Serine Spike protein Spread supported the SARS-CoV-2 transmembrane serine protease Viral virus virus entry viruses [DOI] 10.3390/biom11060855 PMC 바로가기 [Article Type] Review
Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beaconsRT-LAMP 및 분자 표지를 사용한 SARS-CoV-2 RNA 검출Research Published on 2021-06-032022-09-11 Journal: Genome Biology [Category] MERS, SARS, 치료기술, [키워드] alternative Amplicon amplification assays Chain Reaction complicate Concordance coronavirus COVID-19 detection Diagnosis DNA amplification facilitate fluorescent global pandemic gold gold standard human RNA implementation incorporation isothermal amplification LAMP LAMP-BEAC less Loop-mediated isothermal amplification melting temperatures molecular Molecular beacon monomer multiplex nonspecific nucleic acid polymerase polymerase chain reaction Population screening provide purification Rapid rapid assay rapid assays Reactions reagent Result resulting reverse transcription Reverse transcription-polymerase chain reaction robust RT-LAMP RT-PCR RT-qPCR Saliva saliva samples SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 RNA sensitivity Spread supplementary material supply chains thermocyclers Transcription Transmission [DOI] 10.1186/s13059-021-02387-y PMC 바로가기 [Article Type] Research
Cardiac troponin and COVID-19 severity: Results from BIOCOVID studyObservational Study Published on 2021-06-012022-10-05 Journal: European Journal of Clinical Investigation [Category] SARS, 임상, [키워드] 30-Day mortality adjusted odds ratio analysed cardiac cardiac troponin Cardiac troponin I cardiac troponin T characterized COVID-19 COVID-19 patient COVID-19 patients cut-off defined detect died elevated Endpoint evaluated Hospitalization Hospitalized hospitals independent Injury International laboratory-confirmed Mortality multicentre Myocardial myocardial injury nonspecific Patient Prevalence Prognosis prognostic Result retrospective risk stratification SARS-CoV-2 severity Sex significantly significantly higher Spanish total population troponin I troponin level upper reference limit utility was measured was used were used [DOI] 10.1111/eci.13532 PMC 바로가기 [Article Type] Observational Study
Use of Respiratory Protection Devices by Medical Students during the COVID-19 Pandemic †Article Published on 2021-05-282022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] assumed changed coronavirus COVID-19 COVID-19 pandemic Device Effectiveness equipment face Face mask Face masks hygiene majority Mask measure medical students MOST nonspecific organization pandemic participant protection Protective reported respiratory respiratory protection devices RPE shifting student university wear face mask [DOI] 10.3390/ijerph18115834 PMC 바로가기 [Article Type] Article
Influenza vaccination and the risk of COVID-19 infection and severe illness in older adults in the United StatesArticle Published on 2021-05-262022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] 95% CI 95% confidence interval adjusted odds ratio age association caused conducted coronavirus disease country COVID-19 COVID-19 infection COVID-19 patients COVID-19 vaccine COVID-19 vaccines database death evaluated Evidence global pandemic immune response Infection Influenza influenza vaccination measure nonspecific Older outcome Outcomes research PROTECT reduce Retrospective cross-sectional study risk risk of COVID-19 severe COVID-19 illness severity of COVID-19 stimulate study population suggested the United State vaccination Vaccine viral infection [DOI] 10.1038/s41598-021-90068-y PMC 바로가기 [Article Type] Article
High-Surety Isothermal Amplification and Detection of SARS-CoV-2SARS-CoV-2의 고정밀 등온 증폭 및 검출Research Article Published on 2021-05-192022-09-10 Journal: mSphere [Category] SARS, 진단, 치료기술, 치료제, [키워드] absence accumulate addition Amplicon amplicons amplification analyte approach assays binding Boolean logic carried changes complexity COVID-19 described detection diagnostics Diseases employment False negative false negatives False positives false-negative false-negative results False-positive results Fluorescence generate gold gold standard help human resource human saliva Inclusion inefficient Infectious diseases isothermal isothermal amplification isothermal nucleic acid diagnostics LAMP lateral flow Lateral flow assays lead Loop-mediated isothermal amplification maintain Molecular assay multiplex multiplex assays Mutation non-sequence-specific nonspecific nucleic acid nucleic acid amplification pathogen Pathogens point-of-care primer probe probes qPCR quantitative PCR reduce redundancy Region resource resulting SARS-CoV-2 SARS-CoV-2 virion SARS-CoV-2 virions Scaling sequence simplicity strand displacement probes target targets Treatment [DOI] 10.1128/mSphere.00911-20 PMC 바로가기 [Article Type] Research Article
Chloroquine- and Hydroxychloroquine-Induced Cardiomyopathy: A Case Report and Brief Literature Review클로로퀸 및 하이드록시클로로퀸으로 유발된 심근병증: 증례 보고 및 간략한 문헌 검토Review Published on 2021-05-182022-09-11 Journal: American journal of clinical pathology [Category] 진단, 치료제, [키워드] administration antimalarial drug Antimalarial drugs cardiac and skeletal muscle Cardiomyopathy Cardiotoxicity caused change Chloroquine clinical trials coronavirus disease Coronavirus disease 2019 correlation country COVID-19 deposition described diagnosed drug Efficacy Endomyocardial biopsy HCQ histologic Hydroxychloroquine identify Including Inclusion inclusion bodies index case LIGHT literature literature review medical history metabolite myopathies Myopathy nonspecific overlap pathologic pathology Patient report review rheumatic disease Rheumatic diseases severe adverse effect Skeletal muscle the patient the United State United States vacuolated was performed were recorded [DOI] 10.1093/ajcp/aqaa253 PMC 바로가기 [Article Type] Review
Medicinal Plants and Isolated Molecules Demonstrating Immunomodulation Activity as Potential Alternative Therapies for Viral Diseases Including COVID-19Immunology Published on 2021-05-132022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] activity approach attack Bacteria cellular immunity COVID-19 database Defense Demonstrating Diseases displaying effective elicit Glycosides highlight humoral immune system immunomodulation immunomodulator Including Infection Isolated management mechanism mechanisms microorganism modulate molecule MOST natural nonspecific Phytoconstituents plant plants Potential potential therapy reported Research researcher responsible Safe searched therapeutic potential Traditional Chinese medicine Viral diseases viral infections virus [DOI] 10.3389/fimmu.2021.637553 PMC 바로가기 [Article Type] Immunology