Point-of-care COVID-19 diagnostics powered by lateral flow assayReview article Published on 2021-12-012022-10-05 Journal: TrAC Trends in Analytical Chemistry [Category] 바이오마커, 변종, 진단, [키워드] antibodies antigens caused coronavirus disease country COVID-19 COVID-19 pandemic Critical diagnosis of COVID-19 diagnostic diagnostic testing diagnostic tests diagnostics Efficiency Health highlight immunoassay Lateral lateral flow lateral flow assay management mechanism Novel coronavirus Numerous pandemic platform POC point of care Rapid diagnostic test reported researchers RNA SARS-CoV-2 virus [DOI] 10.1016/j.trac.2021.116452 [Article Type] Review article
Biochemical role of serum ferratin and d-dimer parameters in COVID 19 diagnosisReview article Published on 2021-12-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 바이오마커, [키워드] affected Anticoagulant Biochemical parameters Biomarker Blood C-reactive protein can be used clinical symptom clinical trials Coronavirus 2019 COVID 19 COVID-19 COVID-19 infection COVID-19 patient COVID-19 vaccine COVID19 Cytokine storm D-dimer diagnosed diagnosing Diagnosis disease effective Effects Efficacy elevated ferritin level humans identify immune response immunosuppressive Infection instances mandatory Mild moderate Mortality Numerous pandemic parameter Patient polymerase chain pro-inflammatory pulmonary real time reverse transcription risk RT-PCR SARS-CoV-2 serum Serum ferritin severe COVID-19 severity shown symptomatic disease the disease the patient vitamin D levels [DOI] 10.1016/j.sjbs.2021.08.040 [Article Type] Review article
Interaction of Spike protein and lipid membrane of SARS-CoV-2 with Ursodeoxycholic acid, an in-silico analysisArticle Published on 2021-11-152022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 신약개발, [키워드] acid addition Alpha Analysis cholesterol Cluster Computational biology and bioinformatics decrease drug Drug development Dynamics evaluated exhibit form gallstone heptad repeat higher affinity host cell Hydrogen bond in-silico interact Interaction membrane membranes molecular docking monomer Numerous Physicochemical properties prefusion Protein protein sequences random reduce reduction in Region remained residue RMSD RMSF SARS-CoV-2 SARS-COV-2 infection severity shown spike tension the SARS-CoV-2 the Spike trajectory treat Ursodeoxycholic acid Viral hepatitis was performed [DOI] 10.1038/s41598-021-01705-5 PMC 바로가기 [Article Type] Article
Comparative sensitivity evaluation for 122 CE-marked rapid diagnostic tests for SARS-CoV-2 antigen, Germany, September 2020 to April 2021Research Published on 2021-11-042022-10-31 Journal: Eurosurveillance [Category] COVID-19, MERS, SARS, [키워드] acute infection addressed CE mark Comparative COVID 19 eligible Europe evaluated exhibited Germany head-to-head evaluation Healthcare system identify independent less limit minimum MOST Numerous offered PCR performed quantification Rapid diagnostic test RDT Result SARS-CoV-2 SARS-CoV-2 antigen sensitivity Sensitivity and specificity sensitivity evaluation specimen specimens viral loads was used [DOI] 10.2807/1560-7917.ES.2021.26.44.2100441 PMC 바로가기 [Article Type] Research
Current Potential Therapeutic Approaches against SARS-CoV-2: A ReviewReview Published on 2021-11-042022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] ACE2 Antibiotics Antiviral antiviral medicine approach bind combination therapy current dissemination effective enzyme Favipiravir HIV protease inhibitor host cells host-based therapy include inhibitor Medicine morbidity and mortality nucleotide Numerous Potential Prevent priming public health receptor reduce Remdesivir Replication review Ritonavir S protein SARS-CoV-2 SARS-CoV-2 cell entry inhibitors SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pandemic serine protease TMPRSS2 shown TMPRSS2 Treatment virus-based therapy with COVID-19 [DOI] 10.3390/biomedicines9111620 PMC 바로가기 [Article Type] Review
COVID-19-Associated acute respiratory distress syndrome (CARDS): Mechanistic insights on therapeutic intervention and emerging trendsArticle Published on 2021-11-032022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 신약개발, 임상, 치료제, [키워드] Abstract acute respiratory distress antiviral effects ARDS Attention caused Clinical effect clinical trial Complication Coronavirus disease 2019 COVID-19 COVID-19-associated ARDS COVID-19-associated ARDS (CARDS) COVID‐19 current database decrease develop distress drug target effective therapy Effectiveness Effects Elsevier evaluated examined expected feature help immune responses material modulating molecular Molecular drug targets morbidity Mortality Numerous outcomes pathophysiological mechanism pathophysiology Patient pharmacological treatment respiratory SARS-COV-2 infection Significance syndrome systematic review targets Therapeutic approach therapeutic intervention therapeutic option Treatment [DOI] 10.1016/j.intimp.2021.108328 PMC 바로가기 [Article Type] Article
Periodontal Diseases: Major Exacerbators of Pulmonary Diseases?Review Article Published on 2021-11-022022-10-29 Journal: Pulmonary Medicine [Category] COVID-19, [키워드] Affect age association Asthma Bacteria changes in chronic obstructive condition contribute COPD COVID-19 disease Diseases disorders event Factors Frequency Genetic gingivitis Inflammatory responses Intervention lung Lung function Lungs Major microorganism morbidity Mortality Numerous oral disease outcome outcomes periodontal periodontal disease Periodontitis Pneumonia poor quality pulmonary pulmonary disease pulmonary diseases reduced risk significantly spirometry therapy tissue Topic Tuberculosis Volume [DOI] 10.1155/2021/4712406 PMC 바로가기 [Article Type] Review Article
Mapping SARS-CoV-2 Antibody Epitopes in COVID-19 Patients with a Multi-Coronavirus Protein MicroarrayResearch Article Published on 2021-10-272022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] accelerated accessory protein antibody antibody binding sites antibody reactivity antigenic applied binding changes in correlated correlation COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients cross-react cross-reactivity de novo ELISAs endemic human coronavirus enzyme-linked immunosorbent assay epitope Epitopes Evidence full-length HCoV HCoV-NL63 HCoV-OC43 help Human human coronaviruses identify IgA IgG IgM immune increasingly individual infect knowledge mapping MERS-CoV Microarray microneutralization Middle East Mutant SARS-CoV-2 N proteins Numerous ORF3a ORF7a other coronavirus overlapping Patient peptide Protein Proteins reactive reactivity Region regions Research respiratory syndrome coronavirus response responses responses against SARS-CoV SARS-CoV-2 SARS-CoV-2 protein sera shown specificity Spread structural protein the antibody response vaccination Vaccine-induced immunity variants of concern viral evolution viruses was used worldwide pandemic [DOI] 10.1128/Spectrum.01416-21 PMC 바로가기 [Article Type] Research Article
Clinical Predictors of COVID-19 Severity and Mortality: A PerspectiveCellular and Infection Microbiology Published on 2021-10-252022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] absence Biomarker Biomarkers caused Characteristics clinical clinical manifestation Clinical sign COVID-19 COVID-19 cases COVID-19 pandemic COVID-19 severity death diabetes disease Disease progression disease spread effective Factor Human independent knowledge Mental Meta-analysis Mortality Numerous obesity outbreak outcome physical Prognosis radiological Research resource risk factor Risk factors SARS-CoV-2 Sleep Symptoms systematic review the disease unique [DOI] 10.3389/fcimb.2021.674277 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
COVID-19 and lipids. The role of lipid disorders and statin use in the prognosis of patients with SARS-CoV-2 infectionReview Published on 2021-10-252022-10-29 Journal: Lipids in Health and Disease [Category] COVID-19, MERS, [키워드] Anti-inflammatory Antiviral Arterial hypertension available data cardiovascular disease cardiovascular diseases caused Comorbidities coronavirus coronavirus disease Course COVID-19 COVID-19 infection diabetes disorder dyslipidemia Effect greater immunomodulatory IMPROVE lipids Mortality Numerous obesity observational study outcomes pandemic Patient Prognosis prognosis of patient reduced risk risk factor SARS-CoV-2 SARS-COV-2 infection shown statins the SARS-CoV-2 therapy Treatment [DOI] 10.1186/s12944-021-01563-0 PMC 바로가기 [Article Type] Review