Post COVID-19 infection neuromyelitis optica spectrum disorder (NMOSD): A case report-based systematic reviewReview article Published on 2022-04-012022-10-05 Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] article articles Case report Central nervous system chest imaging CNS collected Coronaviridae COVID-19 COVID-19 infection database develop Devic disease disorder English etiologies evaluate Immunoglobulin inclusion criteria loss of vision Neurological disorders Neuromyelitis Optica Neuromyelitis optica spectrum disorder NMOSD Novel coronavirus Other Patient PCR test performed reported review SARS-CoV-2 selected Symptom systematic review Trigger viral infection virus weakness Web of Science were excluded [DOI] 10.1016/j.msard.2022.103697 [Article Type] Review article
Convalescent plasma therapy in patients with severe COVID-19, A single-arm, retrospective studyObservational Study Published on 2022-04-012022-10-04 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 바이오마커, 임상, [키워드] Admission age association Blood Group Characteristics Clinical outcome collected conditions conducted convalescent plasma COVID COVID-19 COVID-19 mortality CP therapy death demographic diagnosed dose Effect effective Effectiveness Efficacy evaluate Evidence hospital discharge Inflammatory biomarker Laboratory laboratory parameter median medical record Mortality Older age Other Patient plasma prothrombin randomized clinical trial respiratory retrospective cohort Retrospective study SARS-CoV-2 Secondary outcomes severe COVID-19 Sex significantly single-arm Stage suggested Symptom the disease therapy Treatment Treatment outcome Viral diseases [DOI] 10.1016/j.micpath.2022.105482 PMC 바로가기 [Article Type] Observational Study
Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies알파카 면역 레퍼토리의 다변량 마이닝은 강력한 교차 중화 SARS-CoV-2 나노바디를 식별합니다Article Published on 2022-03-252022-09-11 Journal: Science Advances [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus approach Beta Beta variant biochemical conserved Conventional coronavirus cross-neutralize cross-neutralizing deuterium epitope functional half-maximal inhibitory concentration hydrogen identify immune mass spectrometry monomeric multivariate nanobodies nanobody Neutralization assay neutralization assays neutralize Next-generation sequencing Other RBD Receptor binding domain receptor binding motif respiratory SARS-CoV-1 SARS-CoV-2 screening strategy side specificity the RBD the SARS-CoV-2 variant virus [DOI] 10.1126/sciadv.abm0220 PMC 바로가기 [Article Type] Article
Improved Binding Affinity of Omicron’s Spike Protein for the Human Angiotensin-Converting Enzyme 2 Receptor Is the Key behind Its Increased Virulence인간 안지오텐신 전환 효소 2 수용체에 대한 오미크론 스파이크 단백질의 향상된 결합 친화도는 독성 증가의 핵심입니다Article Published on 2022-03-212022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affinity Amino acid amino acid residue amino acids angiotensin Antiviral agents binding binding free energies binding free energy characterized complex contribute coronavirus country D38 domain electrostatic interaction enzyme exhibited free energy genomic region hACE2 hACE2 receptor Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human angiotensin-converting enzyme 2 (hACE2) hydrogen hydrogen bonding Improved Increased information Interaction investigated mode molecular molecular dynamics Molecular dynamics simulation Molecular mechanics molecular mechanics-generalized Born surface area (MM-GBSA) mutated Mutation omicron Omicron variant Other pi-stacking RBD receptor Receptor-binding domain Receptor-binding domain (RBD) receptor-binding motif Receptor-binding motif (RBM) residue resulting salt bridges SARS-CoV-2 SARS-CoV-2 RBD Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) spike Spike protein surface area the RBD the spike protein Transmissibility tyrosine variant variant of SARS-CoV-2 virus wild type [DOI] 10.3390/ijms23063409 PMC 바로가기 [Article Type] Article
Operation of a triage committee for advanced life support during the COVID-19 pandemicObservational Study Published on 2022-03-162022-10-05 Journal: Philosophy, Ethics, and Humanities in Medicine : P [Category] 임상, [키워드] ADP affected age ALS candidate Clinical characteristics clinical criteria Comorbidity COVID-19 COVID-19 pandemic decision Decision-making determine effective Ethics Ethics Committees/Consultation evaluated First wave foundation functional Health help implementation include involved less male measure median Older operation Other participated Patient patients evaluated physician Public receive resources SARS CoV-2 severe respiratory failure Spain Support the patient Triage university [DOI] 10.1186/s13010-022-00117-1 PMC 바로가기 [Article Type] Observational Study
Autoimmunity is a hallmark of post-COVID syndrome자가면역은 포스트 코로나 증후군의 특징입니다Comment Published on 2022-03-162022-09-12 Journal: Journal of Translational Medicine [Category] MERS, SARS, 진단, [키워드] age antibody Antigen Antigen array autoantibodies autoantibody Autoimmune disease Autoimmunity BMI body mass index CD8B characteristic control group COVID-19 evaluated Gender hallmark healthy individual humoral IgG IgG antibody IgM antibodies IL-2 infectious agent Latent Latent autoimmunity Long Long COVID males median median age Other Patient patients persistence positive positively correlated post-acute COVID-19 Post-COVID post-COVID syndrome profile respiratory symptoms SARS-CoV-2 self-antigen serological assessment Sex syndrome was done [DOI] 10.1186/s12967-022-03328-4 PMC 바로가기 [Article Type] Comment
The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp테비페넴 피복실을 광범위 약물 내성 시겔라 spp.에 의해 유발된 중증 위장관 감염에 대한 대체 요법으로 재목적화하기Article Published on 2022-03-152024-07-30 Journal: eLife [Category] 세균성이질, [키워드] carbapenems diarrhoea Drug discovery dysentery multi-drug resistance Other Shigella spp [DOI] 10.7554/eLife.69798 PMC 바로가기
Longitudinal Tracking of Immune Responses in COVID-19 Convalescents Reveals Absence of Neutralization Activity Against Omicron and Staggered Impairment to Other SARS-CoV-2 Variants of ConcernCOVID-19 회복기의 면역 반응에 대한 종단적 추적은 우려의 다른 SARS-CoV-2 변종에 대한 오미크론 및 시차 손상에 대한 중화 활성의 부재를 나타냅니다Article Published on 2022-03-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] activity Against Alpha alpha and delta variants analyzed antibodies association B cell B cells Beta cellular immunity cellular response Cellular responses changes in clearance Cohort concern Correlation analysis COVID-19 decrease Delta Delta variants Evaluating flow cytometry Gamma humoral humoral and cellular immunity humoral immune response IgG antibody IgG titer immune Immunity indicate indicated individual investigated lack long-lasting longitudinal memory memory B cell memory B cells neutralization capacity neutralization test Neutralizing antibodies neutralizing antibody omicron Omicron variants Other Patient patients persistence Perturbation phenotype Prospective Study protection Protective response SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 variant SARS-CoV-2 variants sera spike Spike-specific memory B cells surrogate virus neutralization test the disease variant variants variants of concern Viral virus neutralization test was measured Wuhan strain [DOI] 10.3389/fimmu.2022.863039 PMC 바로가기 [Article Type] Article
Inflammatory burden and persistent CT lung abnormalities in COVID-19 patientsArticle Published on 2022-03-112022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] 95% confidence interval Abnormalities abnormality age association C-reactive protein (CRP calculated Clinical course collected Computed tomography COVID-19 COVID-19 patient CRP CT scan D-dimer determinant evaluate females Follow-up Hospital stay Inflammation Inflammatory LOS lowest lung abnormality Lung CT lung damage Measures mechanical ventilation median age Medical research Odds ratio Other outcomes PaO2/FiO2 ratio Pathogenesis Patient performed predictor reported residual Severe COVID-19 pneumonia severity Sex Standard deviation Survivors with COVID-19 [DOI] 10.1038/s41598-022-08026-1 PMC 바로가기 [Article Type] Article
Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates비인간 영장류에서 SARS-CoV-2 변이체에 대한 재조합 단백질 소단위 백신 및 불활성화 백신의 면역원성 및 보호 효능Article Published on 2022-03-032022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 진단, [키워드] ADCC Alpha antibody Antibody titers antibody-dependent cellular cytotoxicity B.1.351 Beta Beta variant binding Breakthrough infection circulating variant COVID-19 vaccine cytokine declined Delta demonstrated domain downregulated effective Efficacy followed by immune memory immunized immunogenicity inactivated Inactivated vaccine increase in Infection Inflammatory cytokine involved lung tissue lung tissues Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer non-human primate omicron Omicron variants Other pathological changes post vaccination Protective protective effect protective mechanism Protein subunit protein subunit vaccine prototype provided RBD Receptor-binding domain reduction respiratory respiratory tracts rhesus macaque rhesus macaques SARS-CoV-2 variant sera significantly Strains Vaccine Vaccines variant Viral Viral load virus VOCs was reduced [DOI] 10.1038/s41392-022-00926-y PMC 바로가기 [Article Type] Article