Deep learning-based model for detecting 2019 novel coronavirus pneumonia on high-resolution computed tomographyArticle Published on 2020-11-052022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] 2019 novel coronavirus Accuracy Clinical practice collected comparable Computed tomography conducted consecutive patient control patient COVID-19 COVID19 dataset deep deep learning diagnosing Efficiency evaluate high resolution CT High-resolution Infectious-disease diagnostics Laboratory other disease Patient patients Pneumonia radiologist Renmin Hospital retrospective tomography university viral infection Wuhan [DOI] 10.1038/s41598-020-76282-0 PMC 바로가기 [Article Type] Article
Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs530 Published on 2020-11-032022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] accelerated acute respiratory syndrome antiviral agent approach binding free energy caused Chloroquine clinical study Computational methods conducted coronavirus COVID-19 COVID-19 pandemic demonstrated disease distribution drug drug library Drug repurposing drugs drugs targeting effort experimental validation free energy perturbation Hydroxychloroquine identify inhibit SARS-CoV-2 inhibitor inhibitors of SARS-CoV-2 inhibitory M pro main protease other disease outcome patients with COVID-19 predicted protease SARS-CoV-2 SARS-CoV-2 main protease selected drug shown Significance therapeutic effect Therapeutic treatment threshold treat Treatment Virtual screening [DOI] 10.1073/pnas.2010470117 PMC 바로가기 [Article Type] 530
Pulmonary Thromboembolism and Infarction Mimicking COVID-19 Symptoms; Report of three CasesCase Report Published on 2020-11-022022-10-27 Journal: Archives of Academic Emergency Medicine [Category] COVID-19, [키워드] clinician condition COVID-19 Diagnosis diagnostic died Dyspnea Fever Infarction mimicking Novel coronavirus other disease overlap Patient presenting pulmonary Pulmonary embolism pulmonary infarction report respiratory respiratory symptom respiratory symptoms SARS-CoV-2 Signs and symptoms Spread Symptom symptoms of infection these symptom Thromboembolism Treatment Venous thrombosis viral infection Wuhan, China PMC 바로가기 [Article Type] Case Report
Perception of COVID-19 Restrictions on Daily Life among Japanese Older Adults: A Qualitative Focus Group StudyArticle Published on 2020-11-012022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] activity age Analysis changes in community-dwelling older adults conducted contribute coronavirus disease COVID-19 Daily examined focus functional group Health inductive content analysis Infection Infection prevention Japan Japanese life mental health Older other disease pandemic participant Perception positive Previous studies Qualitative reduced reducing reported restriction rural urban was performed while [DOI] 10.3390/healthcare8040450 PMC 바로가기 [Article Type] Article
Deep Convolutional Approaches for the Analysis of COVID-19 Using Chest X-Ray Images From Portable DevicesComputational and Artificial Intelligence Published on 2020-10-262022-10-30 Journal: Ieee Access [Category] COVID-19, [키워드] Accuracy acquisition acute respiratory syndrome Analysis approach benefit caused Characteristics Chest radiography Chest X-ray image chest X-ray imaging complementary coronavirus coronavirus disease COVID-19 cross-contamination dataset deep deep learning Device Effect ENhance equipment facilitate greater Image individuals infected with COVID-19 infection control inherent joint other disease pandemic of COVID-19 Patient poor quality provided Research respiratory infection retrieved risk SARS-CoV-2 tissues widespread X-ray portable device [DOI] 10.1109/ACCESS.2020.3033762 PMC 바로가기 [Article Type] Computational and Artificial Intelligence
Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling인터페론 신호 전달의 게놈 전체 단백질 정량적 형질 유전자좌 매핑에 의해 밝혀진 다발성 경화증 보호 HLA 클래스 I 대립 유전자의 기능Research Article Published on 2020-10-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Affect allele alleles Analysis Antigen presentation antigen-presenting function associations Autoimmune B and T cells B cell B cells CD27 Cell characterization contribute cytokine Cytokines demonstrated disease disease-associated Diseases Effect function functions genetic association Genetic association studies genetic associations genetic data Genetic polymorphism genetic polymorphisms genome-wide significant genotyped healthy individual healthy individuals HLA class I HLA class I alleles HLA locus HLA-A HLA-A*02 HLA-B HLA-J Host identify IFN IFNAR2 IFNs IGD Immune cell immune cells immune system immune-mediated disease immune-mediated diseases independent Infectious diseases Inflammatory interferon interferon receptor interferons interferons (IFNs interferons (IFNs) loci memory B cells microorganisms molecular mechanism molecular mechanisms mRNA expression multiple sclerosis neurologic nucleotide other disease other diseases Pathogenesis pathogenic patients performed protein level pseudogene receptor reduced regulated replicated response sclerosis Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs specific type T cell T cells These data to define transcriptional regulation Type I IFN type I interferon type II IFN virus viruses [DOI] 10.1371/journal.pgen.1009199 PMC 바로가기 [Article Type] Research Article
Natural Plant Products: A Less Focused Aspect for the COVID-19 Viral OutbreakPlant Science Published on 2020-10-152022-10-31 Journal: Frontiers in Plant Science [Category] COVID-19, [키워드] antibodies aspect caused Clinical data clinical trial clinical trials conducted contribute contributed coronavirus coronavirus disease of 2019 COVID-19 described develop disadvantage drug Final human disease identify measure medications molecular docking natural natural compounds nCoV Novel coronavirus other disease Outbreaks pandemic Perspective Phytoconstituents plant positive random Replication required Research Scientific community severe acute respiratory syndrome coronavirus 2 tap therapeutic Treatment Trial Vaccine viruses [DOI] 10.3389/fpls.2020.568890 PMC 바로가기 [Article Type] Plant Science
Stem Cell Based Therapy Option in COVID-19: Is It Really Promising?Review Article Published on 2020-10-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] Anti-inflammatory effects Cell cellular therapy China clinical clinical trial COVID-19 COVID-19 patient Efficacy Evidence feature ICTRP information investigated option other disease pharmacological agent Pneumonia public health registry respiratory problems Spread STEM stem cell the disease therapy Treatment trials virus WHO World Health Organization [DOI] 10.14336/AD.2020.0608 PMC 바로가기 [Article Type] Review Article
Impact of COVID-19 on clinical trials and clinical research: A systematic reviewSystematic Review Published on 2020-09-302022-10-30 Journal: Nepal Journal of Epidemiology [Category] COVID-19, [키워드] activity affecting article clinical trial clinical trials Complete confirmed case Coronavirus disease-19 COVID-19 COVID-19 pandemic data integrity deaths disrupting drug Enrollment FDA Follow-up food globe Google health emergency Impact management other disease outcomes pandemic reported Research research capacity SARS-CoV-2 social distancing study visit subject systematic review the United State timeline Treatment Trial turn Vaccine World Health Organization [DOI] 10.3126/nje.v10i3.31622 PMC 바로가기 [Article Type] Systematic Review
COVID-19: In the Eye of the Cytokine StormImmunology Published on 2020-09-242022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] “cytokine storm” acute respiratory distress Administering aging Alleviating ARDS characterized Comorbidity condition COVID-19 COVID-19 case COVID-19 disease severity COVID-19 severity cytokine disorders drug dysregulated eye Factor hyperinflammation identify immune response immunomodulator immunosenecence immunosenescence imperative IMPROVE improvement Inflammation Inflammatory inflammatory state key factor knowledge Lungs MERS Mortality multi-organ failure other disease outcome overactive pathology Patient patients with comorbidities Prognosis Pulmonary edema reducing Research risk risk factor SARS-CoV-1 SARS-CoV-2 Sepsis severe COVID-19 storm the cytokine storm Therapeutic approach therapy with COVID-19 [DOI] 10.3389/fimmu.2020.558898 PMC 바로가기 [Article Type] Immunology