PBMC – Page 9 – Communicable Diseases Research

Single-Cell RNAseq Profiling of Human γδ T Lymphocytes in Virus-Related Cancers and COVID-19 Disease

Article

Published on 2021-11-032022-10-28
Journal: Viruses [Category] COVID-19, MERS,

Screening HLA-A-restricted T cell epitopes of SARS-CoV-2 and the induction of CD8 + T cell responses in HLA-A transgenic mice

Article

Published on 2021-11-022022-10-04
Journal: Cellular and Molecular Immunology [Category] SARS, 치료제,

[키워드] 229E acute respiratory syndrome addition Amino acid Antimicrobial responses Antiviral Asian binding CD8 Cell cell line Combination coronavirus disease Coronavirus-2 COVID-19 COVID-19 patients elicited epitope Epitopes experiment expressing facilitate feasibility functional generate healthy donor HKU1 HLA-A homologous Host immune protection in silico in vivo indicated induce mice nine NL63 OC43 pathology Patient PBMC peptide Peptide vaccines populations predicted prevalent provided RdRp protein Research response robust SARS-CoV SARS-CoV-2 SARS-CoV-2 variants Screening T cell T cell epitope T cell response T cell responses the S protein transgenic mice vaccination Vaccine were used wild-type
[DOI] 10.1038/s41423-021-00784-8 PMC 바로가기 [Article Type] Article

Effects of Bacille Calmette Guerin (BCG) vaccination during COVID-19 infection

Research article

Published on 2021-11-012022-10-05
Journal: Computers in biology and medicine [Category] SARS, 바이오마커, 변종,

[키워드] activities acute respiratory syndrome ADORA3 analysed Analysis Bacille calmette guerin (BCG) BCG BCG vaccination caused CCL4 CCR2 CD33 Comorbidity condition contagious coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID‐19 Critical CXCL1 CXCL8 cytokine DEGs differentially expressed gene Differentially expressed genes driving drug candidate Drug molecules Effect elements enrichment analysis expression expression pattern finding functional Functional enrichment analysis Gene ontology Genes Genetic IFNg IL-17 Infection Interaction investigated ITGB2 miRNA molecular mononuclear cell more difficult Mortality network analysis Novel coronavirus pandemic pathway Pathways PBMC Peripheral blood PPI PTGS2 Regulatory Research SARS-CoV-2 SARS-COV-2 infection severity significantly Spread TFS therapeutic TLR5 transcriptomic vaccination Vaccine virus spread
[DOI] 10.1016/j.compbiomed.2021.104891 [Article Type] Research article

Safety and cross-variant immunogenicity of a three-dose COVID-19 mRNA vaccine regimen in kidney transplant recipients

신장 이식 수혜자에서 3회 접종 COVID-19 mRNA 백신 요법의 안전성 및 교차 변이 면역원성

Article

Published on 2021-11-012022-09-11
Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단,

[키워드] anti-Spike IgG antibody Antigen BNT162b2 BNT162b2 vaccine Cell cells cellular response Cellular responses COVID-19 COVID-19 vaccine cytokine cytokine production delta variant dose doses explained Frequency Heterologous homologous IFN-γ IFN-γ response IFN-γ responses IgG immunogenicity immunosuppressive immunosuppressive therapy increase interferon kidney Kidney function kidney transplant kidney transplant recipient longitudinal study Mild mRNA mRNA vaccine neutralization activity Neutralizing activity neutralizing antibody Nice University Hospital one patient Patient PBMC PBMCs performed raised reaction Reactions recipient recipients regimen remained Safety second dose Seroconversion seronegative significant increase spike-specific IgG tested therapy Tolerability university Vaccine variants variants of concern variants of concern, kidney transplantation.
[DOI] 10.1016/j.ebiom.2021.103679 PMC 바로가기 [Article Type] Article

Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy

항-CD20 요법을 받는 다발성 경화증 환자의 SARS-CoV-2 백신에 대한 체액 및 T 세포 면역 반응 불일치

Article

Published on 2021-11-012022-09-11
Journal: EBioMedicine [Category] MERS, SARS, 진단, 치료기술,

[키워드] anti-CD20 anti-CD20 therapy array CD20 Cell Community COVID COVID-19 COVID-19 infection determine disease Donor donors generosity Genscript glycoprotein humoral Humoral immunity humoral immunity, multiple sclerosis, anti-CD20 therapies. Humoral response humoral responses IFN-γ IgG immune response immune responses immunoassay impair increase in incubated individual interferon gamma Johns Hopkins Johns Hopkins University linear models Mabtech Medicine mRNA vaccines multiple sclerosis participant PBMC PBMCs peptide peptides Plate receptor reduced Research robust SARS-CoV-2 SARS-CoV-2 vaccination School serum SFC Society Spectrum sphingosine sphingosine-1-phosphate spike glycoprotein subset supported T cell T cell response T cell responses T cells tested Therapies therapy translate
[DOI] 10.1016/j.ebiom.2021.103636 PMC 바로가기 [Article Type] Article

Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in the blood of COVID-19 cancer patients

Multi-omic 접근법은 COVID-19 암 환자의 혈액에서 증식에 대한 타고난 면역 반응을 결합하는 전사 네트워크를 식별합니다.

Article

Published on 2021-10-292022-09-12
Journal: Cell Death & Disease [Category] MERS, 임상, 진단,

[키워드] Alter alteration analyses Analysis analyzed approach Blood Cancer cancer patient Cancer patients cancer type CD4 CD8 Cell cell population central memory circulating clinical co-morbidities Cohort conducted contribute controls COVID-19 COVID-19 disease COVID-19 patient cytokine Cytometry Diseases Donor eight elevated enrichment analysis expression Gene Expression Genes highlight homeostasis identify IL-13 IL-6 IL-8 Immune cell immune function immune system immunological parameter immunology Infection Infectious diseases inflammation response innate immune response investigated IP-10 modulated mononuclear cell mortality rates multiplex natural killer outcome Patient PBMC PBMCs performed Peripheral blood plasmablast pro-inflammatory factor proliferation reduced Regulation SARS-COV-2 infection serum cytokine Signaling solid cancers Stage subpopulation T cell T lymphocyte transcriptional worsened
[DOI] 10.1038/s41419-021-04299-y PMC 바로가기 [Article Type] Article

Genome-Wide Profiling Reveals Alternative Polyadenylation of Innate Immune-Related mRNA in Patients With COVID-19

게놈 전체 프로파일링, COVID-19 환자에서 선천적 면역 관련 mRNA의 대체 폴리아데닐화 밝혀냄

Immunology

Published on 2021-10-272022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alternative polyadenylation alternative splicing APA APA regulator Biomarker cascade category caused Clinical treatment coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine production dataset de novo death Diseases effective event highlight human gene human genes human peripheral blood mononuclear cell Immune escape Immunity Infection Infectious diseases Innate innate immune response Innate immunity Interferon-gamma MAPK mechanism mechanisms mononuclear cell mRNA neutrophil neutrophil activation Ontology pandemic patients PBMC performed Peripheral blood Polyadenylation potential therapeutic target Profiling Regulation reported respiratory RNA RNA-seq data SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Variation Viral
[DOI] 10.3389/fimmu.2021.756288 PMC 바로가기 [Article Type] Immunology

Sex-Related Differences in Innate and Adaptive Immune Responses to SARS-CoV-2

Immunology

Published on 2021-10-202022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] Activation addition CD86 chemokine complications Coronavirus disease 2019 COVID-19 CTLs CXCL-10 DCs dendritic cell dendritic cells difference exhibit expression female females healthy HLA-DR Hospitalization IFN-α immune responses in vitro individual Infection initial Innate innate immune response interferon-α lung male males mDC mDCs mechanism monocyte Monocytes mononuclear cell morbidity and mortality not significant PBMC PBMCs pDC pDCs Peripheral blood response responsible reversed SARS-CoV-2 secreted secretion severe disease Sex sex differences significantly higher stimulated Symptoms the patient these cell Treatment upregulated virus
[DOI] 10.3389/fimmu.2021.739757 PMC 바로가기 [Article Type] Immunology

Upregulation of Human Endogenous Retroviruses in Bronchoalveolar Lavage Fluid of COVID-19 Patients

COVID-19 환자의 기관지폐포 세척액에서 인간 내인성 레트로바이러스의 상향 조절

Research Article

Published on 2021-10-062022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제,

[키워드] activated addition age analyzed BALF bronchial cell bronchial cells bronchial epithelial cell Bronchoalveolar lavage fluid Cancer cellular senescence changes in characterized China conditions controls Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia COVID-19 severity Disease progression disease severity dysregulated dysregulation element endogenous endogenous retroviruses epithelial cells examined explain exploration expression Families global pandemic groups HBEC HBECs healthy control healthy controls HERV HERVs Human human bronchial epithelial cells human endogenous retrovirus human endogenous retroviruses identify immune senescence increase in increasing age Infection Inflammation Inflammatory inflammatory pathway Inflammatory response Inflammatory responses Intensive lavage Local lung Lungs mechanism monocyte Monocytes Mortality Older age oncogene outcomes pathophysiological Patient PBMC PBMCs Peripheral blood peripheral blood monocytes Pneumonia populations Potential biomarker potential biomarkers potential therapeutic target provide recognize retroviral retrovirus risk factor SARS-CoV-2 senescent severe COVID-19 Severe COVID-19 pneumonia shown Transcriptome transcriptomes upregulated upregulation
[DOI] 10.1128/Spectrum.01260-21 PMC 바로가기 [Article Type] Research Article

A snapshot of the immunogenicity, efficacy and safety of a full course of BNT162b2 anti-SARS-CoV-2 vaccine in cancer patients treated with PD-1/PD-L1 inhibitors: a longitudinal cohort study

PD-1/PD-L1 억제제로 치료받은 암 환자를 대상으로 한 BNT162b2 항-SARS-CoV-2 백신 전체 과정의 면역원성, 효능 및 안전성에 대한 스냅샷: 종단적 코호트 연구

Article

Published on 2021-10-012022-09-11
Journal: ESMO open [Category] MERS, SARS, 바이오마커, 진단,

[키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive administration anti-SARS-CoV-2 blood sample Blood samples BNT162b2 BNT162b2 anti-SARS-CoV-2 vaccine BNT162b2 vaccine Cancer cancer patient Cancer patients CD4 CD4+ CD4+ T follicular response CD8+ T-cell CD8+ T-cell response cell-mediated immune cellular response Complete coronavirus coronavirus disease coronavirus disease-2019 Course COVID-19 case COVID-19 cases demonstrated Efficacy and safety elicit elicited enrolled enzyme enzyme-linked immunospot assay Focusing follicular humoral IFN-γ Immune checkpoint inhibitors immune response inhibitor interferon interferon-γ interquartile range IQR knowledge longitudinal cohort study mandatory median Messenger RNA mononuclear cell naïve naïve subjects Neutralizing antibodies no difference no differences of BNT162b2 participant Patient patients PBMC PD-1/PD-L1 inhibitors Peripheral blood primary endpoint programmed cell death programmed cell death protein proportion Protein reached reported respiratory response SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody second dose severe acute respiratory syndrome Coronavirus significant increase significantly higher significantly increased Specific T-cell response spike-specific T-cell response subject subjects sustained T cells T-cell Response the primary endpoint treated undetectable vaccination vaccination schedule Vaccine
[DOI] 10.1016/j.esmoop.2021.100272 PMC 바로가기 [Article Type] Article