peptides – Page 9 – Communicable Diseases Research

A multiplex protein panel assay for severity prediction and outcome prognosis in patients with COVID-19: An observational multi-cohort study

Research article

Published on 2022-06-092022-10-05
Journal: EClinicalMedicine [Category] 바이오마커, 임상,

A streamlined platform for analyzing tera-scale DDA and DIA mass spectrometry data enables highly sensitive immunopeptidomics

테라급 DDA 및 DIA 질량 분석 데이터를 분석하기 위한 간소화된 플랫폼으로 고감도 면역펩티드학 가능

Article

Published on 2022-06-072022-09-11
Journal: Nature Communications [Category] COVID19(2023년), SARS, 유전자 메커니즘,

Smaller, Stronger, More Stable: Peptide Variants of a SARS-CoV-2 Neutralizing Miniprotein

더 작고, 더 강하고, 더 안정적: SARS-CoV-2 중화 미니단백질의 펩타이드 변이체

Article

Published on 2022-06-042022-09-11
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] amino acids antiviral activity approach breadth characterized complex de novo Degradation dissect full-length IMPROVE incorporation miniprotein Modification Mutation neutralization Neutralizing neutralizing capacity non-proteinogenic amino acids peptide peptide mimics peptides potency protein expression proteolytic RBD Receptor binding domain Recombinant protein reported resulting retained SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant Smaller Spike protein stability strength structure-based design susceptibility synthetic peptides the RBD the SARS-CoV-2 therapy variant virus virus variant VoC
[DOI] 10.3390/ijms23116309 PMC 바로가기 [Article Type] Article

Potential of antiviral peptide-based SARS-CoV-2 inactivators to combat COVID-19

COVID-19 퇴치를 위한 항바이러스 펩티드 기반 SARS-CoV-2 불활성화제의 가능성

Article

Published on 2022-06-032022-09-11
Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 Antiviral antiviral drug antiviral drugs antiviral therapeutics appearance binding binding energy can be used Candidates caused Cell cells complexes conformational change conformational changes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 effective Effectiveness enzyme evidenced experiment geometric host cells host receptor hydrogen Hydrogen bond hydrogen bonds hydrophobic hydrophobic interactions identify inactivation increase in induce infecting Infectious disease lack membrane fusion molecular molecular dynamics MOST non-toxic peptide peptide-based peptides permeability Potential Protein SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus solvent Spike protein stability surface area target the spike protein Therapies Treatment Vaccine variant viral cell Virtual screening virus water
[DOI] 10.1371/journal.pone.0268919 PMC 바로가기 [Article Type] Article

Antimicrobial Resistance in the COVID-19 Landscape: Is There an Opportunity for Anti-Infective Antibodies and Antimicrobial Peptides?

COVID-19 환경의 항균제 내성: 항감염성 항체 및 항균성 펩티드에 대한 기회가 있습니까?

Review

Published on 2022-06-022022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종,

[키워드] affected AMPs animals antibiotic antibiotic discovery Antibiotic resistance Antibiotics antibody antimicrobial antimicrobial peptide antimicrobial peptides antimicrobial resistance Antimicrobials appearance Bacterial Coinfection COVID-19 develop Diseases Disinfection environmental contamination environmental reservoir environmental reservoirs escape for disinfection global health Health Infectious diseases less measure microorganism microorganisms multidrug-resistant Mutation occur one health one health approach opportunity organism patients with COVID-19 peptides Prevalence Prevent public health reduced required resistance risk SARS-CoV-2 Transmission vaccination Vaccine variants virus
[DOI] 10.3389/fimmu.2022.921483 PMC 바로가기 [Article Type] Review

A conserved subunit vaccine designed against SARS-CoV-2 variants showed evidence in neutralizing the virus

SARS-CoV-2 변이체에 대해 설계된 보존 소단위 백신은 바이러스를 중화하는 증거를 보여주었습니다

Article

Published on 2022-06-012022-09-11
Journal: Applied Microbiology and Biotechnology [Category] COVID19(2023년), SARS, 변종, 치료기술,

[키워드] addition affinity analyzed antibody approach B-cell response conserved coronavirus coronavirus disease country Coverage COVID-19 Cytopathic effect docking domain Efficiency elicit envelope envelope protein epitope Epitope-based vaccine Epitopes Evidence FIVE genomes glycoprotein highest IgG immunogenic immunoinformatics IMPROVE induce linker lung tissue membrane membrane glycoprotein MHC MHC class MHC class I MHC class II mice molecular molecular docking Multi-epitope vaccine Mutation neutralize Neutralizing Neutralizing antibodies neutralizing antibody novel Novel coronavirus omicron outbreak pandemic peptide peptides Proteins recognize reported required S1 and S2 S2 domain SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 variant SARS-CoV-2 variants selected sequence sequences spike Spike surface glycoprotein, Immunogenic, Neutralizing antibody. Spread step subunit Subunit vaccine Surface glycoprotein surface protein surface proteins T-cell T-cell epitope T-cell epitopes the vaccine Vaccine vaccine construct variant variants variants of SARS-CoV-2 Vero Cell viral surface virus virus replication wild type wild-type virus
[DOI] 10.1007/s00253-022-11988-x PMC 바로가기 [Article Type] Article

Antibody and T cell responses to COVID-19 vaccination in patients receiving anticancer therapies

항암치료를 받는 환자의 코로나19 백신접종에 대한 항체 및 T세포 반응

Article

Published on 2022-06-012022-09-11
Journal: Journal for immunotherapy of cancer [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단, 치료기술, 치료제,

[키워드] active treatment adrenal crisis Adrenal insufficiency Affect Anti-CD20 antibodies Anti-CD20 antibody Anti-viral antibodies antibody antibody formation Antibody titer Antibody titers Anticancer therapy B cells B-cell B.1.617.2 blockade Cancer CD4 CD8 Cell cellular Chemoimmunotherapy Chemotherapy Corticosteroids COVID-19 COVID-19 infection COVID-19 infections COVID-19 vaccination COVID-19 vaccinations COVID-19 vaccine trials cross-reactive cytokine detectable develop dose doses effector cells Endocrine expressed follicular generate healthy donor healthy donors helper cells Humoral response hypoadrenalism Hypothesis IgG antibody titer immune Immunocompromised immunogenic immunogenicity immunogenicity, vaccine Immunotherapy intracellular cytokine staining Lymphocytes mRNA vaccine Multiple myeloma Myeloma n=36 no differences oncology patients Participants Patient Patients with cancer PD-1 peptide peptides Phase 3 profile Prophylactic RBD reactivity receiving Receptor binding domain Safe seronegative seronegative patient Side effect solid tumors spike Spike protein steroid Steroids Stress symptomatic T cell T cell response T cell responses T cells T follicular helper cells T-lymphocytes targeted therapy the SARS-CoV-2 therapy Treatment treatment groups tumors Two patient two patients vaccination Vaccinations Vaccine variant spike was measured were assessed were excluded wild-type WT spike
[DOI] 10.1136/jitc-2022-004766 PMC 바로가기 [Article Type] Article

Up-regulated serum levels of interleukin (IL)-17A and IL-22 in Egyptian pediatric patients with COVID-19 and MIS-C: Relation to the disease outcome

COVID-19 및 MIS-C가 있는 이집트 소아 환자의 인터루킨(IL)-17A 및 IL-22의 상향 조절된 혈청 수준: 질병 결과와의 관계

Article

Published on 2022-06-012022-09-11
Journal: Cytokine [Category] COVID19(2023년), SARS, 바이오마커,

[키워드] age ALT antimicrobial peptide antimicrobial peptides ARDS cellular children contribute COVID-19 CRP D-dimer died dimer elevated ELISA epithelial cell epithelial cells ferritin healthy control IL-17A IL-22 Increased infections Inflammatory Inflammatory marker inflammatory markers Interleukins LDH Level lymphopenia MIS-C MIS–C neutropenia neutrophilia not correlated outcome pathology Pathways Patient patients patients with COVID-19 patients with SARS-CoV-2 Pediatric patient peptides Protective relation Sample size SARS-CoV-2 serum serum ferritin level Serum level serum levels signaling pathways significantly higher stimulate syndrome synergistic synergistic action the disease thrombocytopenia up-regulated were measured with COVID-19
[DOI] 10.1016/j.cyto.2022.155870 PMC 바로가기 [Article Type] Article

Persistence of immune responses to the Sinopharm/BBIBP-CorV vaccine

Sinopharm/BBIBP-CorV 백신에 대한 면역 반응의 지속성

Article

Published on 2022-06-012022-09-11
Journal: Immunity, Inflammation and Disease [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] ACE2 age all age groups angiotensin Angiotensin-converting enzyme antibody Antibody Response Antibody responses assays blocking antibodies Cell Cohort COVID-19 declined detectable determine Efficacy ELISPOT ELISpot assays enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Ex vivo group groups Hospitalization immune response immune responses Immunity individual individuals interferon gamma investigated Kinetics long term memory B memory B cell overlapping peptide peptides persistence Protein RBD receptor Receptor-binding domain remained response SARS-CoV-2 second dose severe disease Sinopharm Sinopharm/BBIBP-CorV Spike protein T cell T cell response T cell responses the RBD the receptor-binding domain the spike protein the vaccine total antibodies total antibody Vaccine Vaccines variants variants of concern virus were assessed were measured
[DOI] 10.1002/iid3.621 PMC 바로가기 [Article Type] Article

Subtractive proteomics assisted therapeutic targets mining and designing ensemble vaccine against Candida auris for immune response induction

감산 단백질체학 보조 치료 표적 마이닝 및 면역 반응 유도를 위한 Candida auris에 대한 앙상블 백신 설계

Article

Published on 2022-06-012022-09-11
Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] antigenic approach B cell Candida Candida auris candidate caused characterization Co-infection COVID-19 COVID-19 patient CTL demonstrated effective effective therapy Efficacy feature global pandemic HTL IgG IgM IL-6 immune immune response Immune simulation immunogenic peptide in-silico Infection infections interferon Interferon-α molecular docking Multi-epitope vaccine non-allergenic peptides producing proteome proteomics provide SARS-CoV-2 Seven Subtractive proteomics target targets the vaccine therapeutic target therapeutic targets threshold Vaccine vaccine candidate vaccine candidates Vaccines validation variant variants was performed
[DOI] 10.1016/j.compbiomed.2022.105462 PMC 바로가기 [Article Type] Article