Expanding access to SARS-CoV-2 IgG and IgM serologic testing using fingerstick whole blood, plasma, and rapid lateral flow assays핑거스틱 전혈, 혈장 및 신속한 측면 흐름 분석을 사용하여 SARS-CoV-2 IgG 및 IgM 혈청학적 검사에 대한 접근 확대Article Published on 2021-08-012022-09-12 Journal: Journal of Clinical Virology [Category] MERS, SARS, 진단, [키워드] Abbott antibodies Asymptomatic automated Blood can be used capillary blood collected Concordance controls convalescent plasma DBS sample DBS samples Diagnosis disease donors Dried blood spots Efficacy examined expand fingerstick IgM lateral flow linearity Microtainer Patient PCR-confirmed COVID-19 plasma plasma sample point-of-care positive R 2 Rapid rapid diagnostics reproducibility SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 testing serologic serologic testing serology testing stability Symptom Vaccine venous Whole blood whole blood sample [DOI] 10.1016/j.jcv.2021.104855 PMC 바로가기 [Article Type] Article
SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assayResearch Article Published on 2021-07-302022-10-28 Journal: Science Advances [Category] COVID-19, [키워드] acute respiratory syndrome antibody antibody assay Antibody Response Antibody titers assays Clinical presentations coronavirus correlation cough defined dependent on detect disease severity driven by Fever Hospitalization implication individual Infection Interpretation magnitude mild infection neutralization nucleocapsid Oxygen requirement plasma sample response SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection sensitivity severity Spike protein [DOI] 10.1126/sciadv.abh3409 PMC 바로가기 [Article Type] Research Article
High-dose intravenous immunoglobulins might modulate inflammation in COVID-19 patients고용량 정맥 면역 글로불린은 COVID-19 환자의 염증을 조절할 수 있습니다Research Article Published on 2021-07-282022-09-10 Journal: Life Science Alliance [Category] SARS, 바이오마커, 진단, [키워드] Activation administration analyzed C5a chemokine chemokines clinical evolution complement Complement activation Course COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines Factor Fatty acid FIVE hepatic growth factor High-dose high-dose IVIg hospitalized COVID-19 patient Hyperinflammatory hyperinflammatory status IL-10 IL-5 IL-7 immune response immune responses immunoglobulins immunomodulator immunomodulators immunomodulatory properties immunomodulatory property immunosuppressive IMPROVE individual individuals Inflammation Inflammatory Inflammatory biomarker inflammatory biomarkers intestinal Intravenous immunoglobulin IVIG Macrophage modulate modulating patients plasma sample plasma samples Protein reduced Respiratory function restored shown treated Treatment treatment initiation Tumor tumor necrosis tumor necrosis factor [DOI] 10.26508/lsa.202001009 PMC 바로가기 [Article Type] Research Article
Predicting the efficacy of COVID-19 convalescent plasma donor units with the Lumit Dx anti-receptor binding domain assay루트 DX 항-수용체 결합 도메인 분석과 함께 COVID-19 회복기 혈장 공여체 유닛의 효능 예측Research Article Published on 2021-07-262022-09-10 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, 진단, [키워드] anti-RBD Anti-RBD antibodies Anti-RBD antibody antibody Antibody assays Antibody titer Antibody titers barrier benefit binding domain cause CCP characteristic clinically convalescent plasma correlated COVID-19 death determined by Donor Efficacy greater house immunization in-house ELISA measure neutralization Neutralizing titer neutralizing titers Novel coronavirus observation passive immunization plasma plasma sample plasma samples Promega Protein provide RBD Receptor binding domain recipients Result S protein Safe SARS-CoV2 SARS-CoV2 S protein Serological assay Study design Support therapeutic option therapy total Ig Viral Virus neutralization were measured with COVID-19 [DOI] 10.1371/journal.pone.0253551 PMC 바로가기 [Article Type] Research Article
Unlikely SARS-CoV-2 Transmission During Vaginal Delivery질 전달 중에 SARS-COV-2 전염은 거의 없습니다Maternal Fetal Medicine/Biology: Short Communication Published on 2021-07-222022-09-10 Journal: Reproductive Sciences [Category] MERS, SARS, 치료기술, [키워드] Blood blood specimens characterized COVID-19 disease COVID-19 disease severity delivery detect disease enrolled Faeces higher risk immune system Infection Intrapartum vertical transmission nasopharyngeal swabs patients plasma sample plasma samples positive Pregnancy pregnant women progression qPCR rectal rectal swab Rectal swabs SARS-CoV-2 SARS-CoV-2 transmission secretion specimen subject tested tolerogenic Transmission unlikely Vaginal Vaginal fluid vaginal swab vaginal swabs vertical transmission Viral Viral load virus virus particle virus particles was performed women [DOI] 10.1007/s43032-021-00681-5 PMC 바로가기 [Article Type] Maternal Fetal Medicine/Biology: Short Communication
Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infectionSARS-CoV-2 감염의 급성 후유증에서 폐 기능 장애의 면역 섬유증 드라이버Clinical Medicine Published on 2021-07-222022-09-12 Journal: JCI Insight [Category] SARS, 진단, [키워드] acute COVID-19 acute COVID-19 illness affected alveolar American Heart Association Analysis Award Benign carbon monoxide Clinical data correlated cough COVID-19 COVID-19 illness COVID-19 severity declined diffusing diffusing capacity discriminant analysis donation driver Duke Dyspnea element enrolled expiratory Factor Factors fibrosis forced expiratory volume forced vital capacity foundation funding FVC Growth factors heart hematology HGF Hospitalized ICU impaired lung function impairment individual Inflammatory intensive care intensive care unit interquartile range Lcn2 lipocalin-2 lung median Mild multiplex neutrophil neutrophil activation Neutrophils Partial participant PASC performed plasma biomarker plasma sample plasma samples profile prognostic Program prospective cohort study Pulmonary function Pulmonary function tests Pulmonology recovering from COVID-19 respiratory symptom respiratory symptoms SARS-COV-2 infection severity Signaling significantly higher Subjective Symptom Symptoms targets therapeutic university validation cohort vital capacity Volume with COVID-19 Yale University [DOI] 10.1172/jci.insight.148476 PMC 바로가기 [Article Type] Clinical Medicine
Chronic Obstructive Pulmonary Disease Patients Have Increased Levels of Plasma Inflammatory Mediators Reported Upregulated in Severe COVID-19만성 폐쇄성 폐질환 환자, 심각한 COVID-19에서 상향 조절되는 것으로 보고된 혈장 염증 매개체 수치 증가Immunology Published on 2021-07-152022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] “COVID-19 age asthmatic asthmatic patient Asthmatic patients Biomarker biomarker signature Calu-3 cell calu-3 cells CCL11 CCL3 CCL4 chemokine chemokine signaling pathway chemokine signaling pathways chemokines chronic chronic obstructive pulmonary disease controls COPD COVID-19 COVID-19 pandemic CX3CL1 CXCL1 CXCL10 CXCL11 CXCL9 database disease driven by drug dysregulation experimental validation females gene signature gene signatures healthy control healthy controls HGF IL-6 IL-6 level IL-6 levels IL6 immune in some Increased increased risk Infection Inflammatory involved Level MCP-3 mechanism mediator mediators Obstructive obstructive pulmonary disease Patient plasma protein plasma proteins plasma proteomics plasma sample plasma samples Protein protein levels pulmonary pulmonary disease quantified RAGE recruited reported Result SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Significant susceptibility susceptible systemic inflammatory tested TNF up-regulated Viral viral infection viral infections [DOI] 10.3389/fimmu.2021.678661 PMC 바로가기 [Article Type] Immunology
Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern에피토프 특이적 항체 반응으로 COVID-19 결과와 우려 변종 차별화Clinical Medicine Published on 2021-07-082022-09-10 Journal: JCI Insight [Category] SARS, 변종, 진단, 치료법, [키워드] Action antibody antibody profiling Antibody Response Antibody responses Antibody testing Antigen antigens B.1.1.7 Clinical outcome Clinical severity complex complexity coronavirus COVID-19 detect develop epitope epitope peptide Epitopes foundation Health Sciences high resolution High-resolution Humoral immunity identify immunoassay immunoglobulins Infection Infectious disease Innovation linear epitope linear epitopes London Microarrays Mutation N protein Neutralizing Neutralizing antibodies Non-neutralizing antibodies nucleocapsid ORF organization outcome P681H patient survival peptide peptides plasma sample plasma samples positively correlated predict produced Protein Rapid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteome Science screened serology test serology tests specificity the SARS-CoV-2 Toronto university variant variants variants of concern [DOI] 10.1172/jci.insight.148855 PMC 바로가기 [Article Type] Clinical Medicine
Pre-existing asthma as a comorbidity does not modify cytokine responses and severity of COVID-19Research Published on 2021-07-082022-10-28 Journal: Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology [Category] COVID-19, [키워드] Asthma asthma patient asthmatic Blood CCL2 circulating clinical information collected Comorbidity Concentration correlation COVID-19 COVID-19 infection COVID-19 patient COVID-19 progression COVID-19 severity Critical CRP CXCL10 cytokine cytokine response Cytokine storm disease severity group groups healthy subject Hospital stay IL-6 IL-8 immune response Impact implicated John Radcliffe Hospital Mild modify Mortality neutrophil counts no difference occur Oxford oxygen saturation Patient plasma sample Prevalence Protein respiratory virus Result severity of COVID-19 significant difference Total were measured [DOI] 10.1186/s13223-021-00569-8 PMC 바로가기 [Article Type] Research
Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in WuhanArticle Published on 2021-07-062022-10-04 Journal: Nature Communications [Category] SARS, 임상, 치료기술, 치료법, [키워드] acute respiratory syndrome Adaptive immunity age antibodies antibody Antibody Response Antibody titer Antimicrobial responses convalescent convalescent COVID-19 patient convalescent plasma coronavirus coronavirus disease COVID-19 COVID-19 pandemic decrease Diagnosis domain Donor exceeded facilitate female Health humoral immune response IgG antibody IgG response immune memory Immunity initial male Neutralizing antibody titer older patient patients plasma plasma sample positive correlation positive rate promote reduce responses risk SARS-CoV-2 Spike protein the patient therapy Vaccine viral infection Wuhan Wuhan, China [DOI] 10.1038/s41467-021-24230-5 PMC 바로가기 [Article Type] Article