potential therapeutic target
[용어속성] Term
The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression on the Incidence and Severity of COVID-19 Infection
Review
[키워드] ACE2
ACE2 expression
angiotensin-converting enzyme 2
Anti-viral
Community
comorbid condition
coronavirus
COVID-19
COVID-19 infection
COVID-19 pandemic
COVID-19 pathogenesis
Evidence
explain
functional
global effort
group
groups
highlight
Hypothesis
Impact
incidence
Infection
Interaction
International
Mortality
novel coronavirus disease
pandemic
potential therapeutic target
Prevalence
preventive measure
public health
raised
SARS-CoV-2
severity of COVID-19
Support
therapeutic
Variation
viral spike protein
[DOI] 10.3390/pathogens10030379 PMC 바로가기 [Article Type] Review
[DOI] 10.3390/pathogens10030379 PMC 바로가기 [Article Type] Review
Drug design and repurposing with DockThor-VS web server focusing on SARS-CoV-2 therapeutic targets and their non-synonym variants
SARS-CoV-2 치료 표적 및 비동의어 변이체에 초점을 맞춘 DockThor-VS 웹 서버를 통한 약물 설계 및 용도 변경
Article
[키워드] (RdRp)
3CLpro
3D structure
caused
Computational platforms and environments
COVID-19
curated
disease
docking
domain
drug
Drug repurposing
effective
experiment
facilitate
FDA-approved drug
FDA-approved drugs
genetic information
Health Organization
High-throughput screening
identify
market
methodology
MPro
Mutation
N protein
Non-synonymous
Nsp12
Nsp15
Nsp3
nsp5
pandemic disease
Papain
performed
platform
PLPro
potential therapeutic target
potential therapeutic targets
present
provide
RdRP
SARS-CoV-2
SARS-CoV-2 infections
SARS-CoV-2 virus
selected
spike
Structure
Structure-based drug design
the SARS-CoV-2 virus
therapeutic target
therapeutic targets
Treatment
variant
variations
Virtual drug screening
Virtual screening
web server
WHO
wild type
World Health Organization
[DOI] 10.1038/s41598-021-84700-0 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41598-021-84700-0 PMC 바로가기 [Article Type] Article
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients
Inflammasomes는 SARS-CoV-2 감염에 반응하여 활성화되며 환자의 COVID-19 중증도와 관련이 있습니다.
Article
[키워드] activated
Activation
Autopsy
caspase-1
characterized
cleavage
Clinical outcome
correlated
COVID-19
COVID-19 patients
COVID-19 severity
disease severity
IL-18
IL-1β
IL-6
Inflammasome
inflammasome activation
Inflammation
Inflammatory
inflammatory process
LDH
marker
moderate
molecular
NLRP3 inflammasome
Organ failure
outcome
pathophysiology
Patient
patient death
PBMC
platform
potential therapeutic target
promote
SARS-COV-2 infection
sera
severe COVID-19 patients
severity
the disease
tissue
with COVID-19
[DOI] 10.1084/jem.20201707 PMC 바로가기 [Article Type] Article
[DOI] 10.1084/jem.20201707 PMC 바로가기 [Article Type] Article
Senescent cells as promising targets to tackle age-related diseases
Review article
[키워드] also known as Akt
also known as E3 ubiquitin-protein ligase Mdm2
group 2A
group 2D
(p)Rb(phosphorylated) retinoblastoma protein
(phosphorylated) retinoblastoma protein
AKTProtein kinase B
An activating Natural Killer (NK) cell receptor
Anti-apoptotic B-cell lymphoma
Ataxia telangiectasia and Rad3-related protein
Ataxia-telangiectasia mutated
ATMAtaxia-telangiectasia mutated
ATRAtaxia telangiectasia and Rad3-related protein
BclAnti-apoptotic B-cell lymphoma
Biomarker
Cell
cell cycle arrest
cellular senescence
Characteristics
Checkpoint kinase 2
Chk2Checkpoint kinase 2
clearance
contribute
DDRDNA damage response
disease
DNA damage response
DNA segments with chromatin alterations reinforcing senescence
DNA-SACRSDNA segments with chromatin alterations reinforcing senescence
ERKextracellular signal-regulated kinases
examined
extracellular signal-regulated kinases
Forkhead box protein O4
FOXO4Forkhead box protein O4
genotoxic
hallmark
health system
heat shock protein
highlight
HSP90Heat shock protein
IkBInhibitor of nuclear factor kappa B
IKKIκB kinase
ILInterleukin
IMMP2LInner mitochondrial membrane peptidase subunit 2
immune system
Inhibitor of nuclear factor kappa B
Inner mitochondrial membrane peptidase subunit 2
interleukin
Interleukin-1 receptor-associated kinase 1
investigated
IRAK1Interleukin-1 receptor-associated kinase 1
IκB kinase
Mammalian target of rapamycin complex 1/2
MAPKmitogen-activated protein kinase
MDM2Mouse double minute 2 homolog
mechanism
mitogen-activated protein kinase
Mitogen-activated protein kinase-activated protein kinase 2
MK2Mitogen-activated protein kinase-activated protein kinase 2
Mouse double minute 2 homolog
mTORC1/2Mammalian target of rapamycin complex 1/2
NADPHNicotinamide adenine dinucleotide phosphate
NEMONF-kappa-B essential modulator
NF-kappa-B essential modulator
NF-kBNuclear factor – κB
Nicotinamide adenine dinucleotide phosphate
NKG2AAn activating Natural Killer (NK) cell receptor
NKG2DAn activating Natural Killer (NK) cell receptor
Nuclear factor – κB
occur
OISOncogene-induced senescence
Oncogene-induced senescence
organism
phosphatase and tensin homolog
Phosphoinositide 3-kinases
physiological
PI3KPhosphoinositide 3-kinases
PICSPTEN-loss–induced cellular senescence
Potential
potential therapeutic target
Premature
Protein kinase B
PTEN-loss–induced cellular senescence
PTENphosphatase and tensin homolog
reactive oxygen species
replicative
Research
ROSreactive oxygen species
SA-β-GalSenescence-associated beta-galactosidase
SAHFSenescence-associated heterochromatin foci
SAMSenescence-accelerated mice
SASPsenescence-associated secretory phenotype
Senescence-accelerated mice
Senescence-associated beta-galactosidase
Senescence-associated heterochromatin foci
senescence-associated secretory phenotype
senescent cell
SIRT1Sirtuin 1
Sirtuin 1
Stressor
target
therapeutic approaches
therapy
Therapy induced senescence
TISTherapy induced senescence
wound healing
[DOI] 10.1016/j.arr.2020.101251 [Article Type] Review article
[DOI] 10.1016/j.arr.2020.101251 [Article Type] Review article
Title of article: Mucosal-associated invariant T cells in lung diseases
Review
[키워드] 5-OE-RU, 5-(2-oxoethylideneamino)-5-dribitylaminouracil
5-OP-RU, 5-(2-oxopropylideneamino)-5-dribitylaminouracil
6-FP, 6 formylpterin
activated
adaptive
AHR, airway hyper responsiveness
APC, antigen presenting cell
Asthma
BALF, bronchoalveolar lavage fluid
CAP, Community-acquired pneumonia
CCR, CC receptor
CD, cluster of differentiation
Cell
CF, cystic fibrosis
chronic obstructive
COPD, Chronic obstructive pulmonary disease
COVID-19
COVID-19, Coronavirus disease 2019
CXCR, chemokine CXC receptor
cytokine receptor
Disease progression
DN, double negative
dynamic balance
Effects
Evidence
FEV1, forced expiratory volume in the first second
GM-CSF, granulocyte–macrophage colony-stimulating factor
Gzm, granzyme
HIF-1α, hypoxia-inducible factor-1α
HLA-DR, human leukocyte antigen DR
IFN-γ, interferon-γ
IL, interleukin
IL4I1, interleukin-4-induced gene 1
ILCs, innate lymphoid cells
Immune cell
immune response
Immunity
Immunopathogenesis
Infection
Inflammation
Injury
iNKT, invariant natural killer T
involved
lung
lung cancer
Lung disease
Lung diseases
Lungs
maintain
MAIT, Mucosal-associated invariant T
marker
MHC, major histocompatibility complex
microbial infection
MR1, MHC-related protein 1
Mucosa-associated invariant T cells
murine
Pathogenesis
PD-1, programmed cell death protein 1
PLZF, promyelocytic leukemia zinc finger
Pneumonia
potential therapeutic target
Protective
pulmonary disease
pulmonary inflammation
pulmonary tuberculosis
respiratory epithelium
RORγt, retinoic-acid-related orphan receptor γt
SARS-CoV-2
shown
SLE, systemic lupus erythematosus
STAT3, signal transducer and activator of transcription 3
subset
T cell
T cell receptor
T cells
TB, Tuberculosis
TCF7, transcription factor 7
TCR, T cell receptor
Th, T helper
these cell
title
TLR, Toll-like receptor
TNF-α, tumor necrosis factor-α
Treatment
[DOI] 10.1016/j.intimp.2021.107485 PMC 바로가기 [Article Type] Review
[DOI] 10.1016/j.intimp.2021.107485 PMC 바로가기 [Article Type] Review
In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19
Pharmacology
[키워드] ACE2
Against
Analysis
analyzed
approved drugs
artificial
artificial neural networks
cells
clinical trials
Compound
COVID-19
downloaded
drug
Drug repurposing
drugs
goblet secretory cells
highest
Human
human tissues
identify
ileal absorptive enterocyte
immune system
in silico
interactome
lung
nasal
network
Neural
overexpressed
Patient
performed
Potential
potential therapeutic target
predict
Protein
receiver operating characteristics
repurposing
RNA
screened
severe COVID-19 patients
significantly
Single-cell RNA sequencing
System
target
therapeutic target
TMPRSS2
treating COVID-19 patient
Treatment
type II pneumocytes
urgency
[DOI] 10.3389/fphar.2021.598925 PMC 바로가기 [Article Type] Pharmacology
[DOI] 10.3389/fphar.2021.598925 PMC 바로가기 [Article Type] Pharmacology
Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections
Observational Study
[키워드] acute respiratory syndrome
airway
CD123
circulating
coronavirus
COVID-19 negative
COVID-19 patients
CXCL12
dendritic cell
disease
epithelial cells
exhibiting
Health
HSV-1
identify
IFNα
IFNλ
increase
independent
Infection
innate antiviral immunity
Interleukin-3
marker
mice
Mortality
outcome
Patient
pDC
pDCs
plasma
plasmacytoid dendritic cell
potential therapeutic target
Predictive
Prognostic marker
Prospective Study
pulmonary diseases
recruitment
reduce
reduced
Risk factors
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 infections
secretion
severe COVID-19
severity
Treatment
viral infection
viral infections
Viral load
[DOI] 10.1038/s41467-021-21310-4 PMC 바로가기 [Article Type] Observational Study
[DOI] 10.1038/s41467-021-21310-4 PMC 바로가기 [Article Type] Observational Study
The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2
Cellular Response to Infection
[키워드] Activation
Antiviral
antiviral activity
cathepsin
Cell
cellular entry
cleavage
cleavage site
consequence
coronavirus
COVID-19
entry of SARS-CoV-2
exacerbated
expression
furin cleavage
furin cleavage site
furin-like protease
glycoprotein
IFITM
IFITM2
IFITM3
individuals
inhibit
inhibited
innate immune
Innate immunity
interferons (IFNs
late endosomes
maturation
membrane protein
mitigate
polybasic
potential therapeutic target
precursor
producer cell
promote
protease
Protein
reduce
reduce viral replication
Replication
restrict
S1/S2 boundary
SARS-CoV-1
SARS-CoV-1 and -2
SARS-CoV-2
SARS-CoV-2 entry
SARS-CoV-2 replication
SARS-CoV-2 spike
sensitivity
Site
spike
suggested
the spike protein
therapeutic strategy
transmembrane
Transmissibility
transmissibility of SARS-CoV-2
Transmission
Treatment
Type
type 1 interferon
type I
type I IFNs
type I interferon
type II IFN
viral entry
viral spike
viruses
[DOI] 10.1128/JVI.02422-20 PMC 바로가기 [Article Type] Cellular Response to Infection
[DOI] 10.1128/JVI.02422-20 PMC 바로가기 [Article Type] Cellular Response to Infection
Drug designing against NSP15 of SARS-COV2 via high throughput computational screening and structural dynamics approach
고 처리량 컴퓨터 스크리닝 및 구조 역학 접근을 통한 SARS-COV2의 NSP15에 대한 약물 설계
Article
[키워드] (lopinavir
(ritonavir)
addition
approach
best
binding
binding affinity
butanamide
complement
Compound
computational analysis
contribute
COVID-19
Critical
dataset
dihydrofuran-2(3H)-one
drug
drug candidate
effective
endonuclease
ethyl
explicit
Favipiravir
feature
generate
High Throughput Screening
host immune system
identify
Interference
lead
Lopinavir
molecular dynamics
molecular dynamics simulations
Nsp15
oseltamivir
outbreak
pandemic
pharmacophore
potential therapeutic target
Protein
pyrazine
Replication
Ritonavir
rule
SARS-CoV2
screened
selected
selective
small molecule
therapeutic
training set
Treatment
unique
virulence
was selected
[DOI] 10.1016/j.ejphar.2020.173779 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.ejphar.2020.173779 PMC 바로가기 [Article Type] Article