Posaconazole or isavuconazole as sole or predominant antifungal therapy for COVID-19-associated mucormycosis. A retrospective observational case seriesObservational Study Published on 2022-07-012022-10-04 Journal: International Journal of Infectious Diseases [Category] 임상, [키워드] AmB antifungal therapy applicability assumed CAM case sery comparable consecutive patient COVID-19 cured death evaluated Factor Follow-up Fungal infection India Infection isavuconazole lack Mucormycosis outcome Patient patients died Posaconazole predominant reported retrospective second wave survival Therapeutic Drug Monitoring therapeutic effect therapy Treatment Treatment response was used [DOI] 10.1016/j.ijid.2022.04.009 PMC 바로가기 [Article Type] Observational Study
Effectiveness of an mRNA vaccine booster dose against SARS-CoV-2 infection and severe COVID-19 in persons aged ≥60 years and other high-risk groups during predominant circulation of the delta variant in Italy, 19 July to 12 December 20212021년 7월 19일부터 12월 12일까지 이탈리아에서 델타 변이가 우세한 순환 기간 동안 60세 이상의 사람 및 기타 고위험군에서 SARS-CoV-2 감염 및 중증 COVID-19에 대한 mRNA 백신 추가 용량의 효과Article Published on 2022-07-012022-09-11 Journal: Expert review of vaccines [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval administration Asymptomatic booster booster dose booster vaccination circulation Comorbidities Comorbidity completion COVID-19 death declined delta variant Effectiveness Europe group healthcare Hospitalization Immunocompromised Infection information Italy mRNA vaccine peaked predominant Research design SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease Support symptomatic vaccination Vaccine vaccine effectiveness variant [DOI] 10.1080/14760584.2022.2064280 PMC 바로가기 [Article Type] Article
Biotransformation and transplacental transfer of the anti-viral remdesivir and predominant metabolite, GS-441524 in pregnant rats임신한 쥐에서 항바이러스성 렘데시비르와 주요 대사산물인 GS-441524의 생체변환 및 태반 전이Article Published on 2022-07-012022-09-11 Journal: EBioMedicine [Category] 치료제, [키워드] amniotic Amniotic fluid Anti-viral approved AUC Biotransformation Blood Blood-placental barrier C max coronavirus disease Coronavirus disease 2019 COVID-19 cross during pregnancy evaluated fetus GS-441524 Hypothesis Liquid chromatography mass spectrometry maternal blood metabolite Microdialysis MONITOR mother multisite nucleoside parameter pharmacokinetic pharmacokinetics Placenta placental barrier predominant Pregnancy pregnant RATs Remdesivir Science shown Taiwan Tandem mass spectrometry technology tissues transfer treat Treatment UHPLC was used while [DOI] 10.1016/j.ebiom.2022.104095 PMC 바로가기 [Article Type] Article
Evaluation of long-term stability of SARS-CoV-2 nucleic acid extracted from human nasopharyngeal samples인간 비인두 샘플에서 추출한 SARS-CoV-2 핵산의 장기 안정성 평가Article Published on 2022-07-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition analyzed changes checked coronavirus Ct value cut-off detect first test Genes human RP identify Laboratory maintenance media must N1 and N2 nasopharyngeal sample nasopharyngeal specimen New coronavirus predominant protocols Quality-assurance Randomly researchers respond RNA RNA sample RNA samples RT-PCR assay RT-qPCR SARS-CoV-2 gene SARS-CoV-2 genes SARS-CoV-2 nucleic acid significant increase stability subsequent viability virus [DOI] 10.1016/j.jviromet.2022.114529 PMC 바로가기 [Article Type] Article
Omicron BA.2 Lineage, the “Stealth” Variant: Is It Truly a Silent Epidemic? A Literature ReviewOmicron BA.2 계보, "스텔스" 변종: 정말 조용한 전염병입니까? 문헌 검토Review Published on 2022-06-302022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral drugs Asian BA.2 Characteristics coronavirus dominant Epidemic epidemic curve European event FIVE Immunity Infection Lineage lineages literature Monkeypox Neutralizing antibodies neutralizing antibody omicron Omicron variant outbreak pathogenicity predominant public health recombinant variant replication advantage review rising SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus silence stealth variant. Transmissibility unlikely vaccination Vaccine variant Virological VoC XE [DOI] 10.3390/ijms23137315 PMC 바로가기 [Article Type] Review
Contrasting Epidemiology and Population Genetics of COVID-19 Infections Defined by Multilocus Genotypes in SARS-CoV-2 Genomes Sampled Globally전 세계적으로 샘플링된 SARS-CoV-2 게놈의 다중 유전자형에 의해 정의된 COVID-19 감염의 대조 역학 및 인구 유전학Article Published on 2022-06-292022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, [키워드] aligned allele frequency alleles Alpha Amino acid amino acids Analysis Asia association Beta caused Cluster Clustering codon component continent continuous surveillance COVID-19 COVID-19 case COVID-19 incidence COVID-19 vaccine COVID-19 vaccines criteria deaths delta variant demographic data demographics demonstrated dependent on discriminant analysis distribution eight epidemiological Epidemiology Evolution Gamma Genetic genetics Genome genomes Genomic surveillance Genotype genotyping geographical regions GISAID help higher risk Inclusion inclusion criteria Intervention linkage Local loci majority matrix MONITOR multilocus Mutation mutation and transmission. North North America nucleocapsid older patient older patients ORF1ab ORF3a ORF8 persistence polymorphism Population populations predominant Prevalence reference genome repertoire Result risk of infection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 genomic surveillance SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 reference genome selected South America spatiotemporal Spread suggested the SARS-CoV-2 These data Transmission utility variant variants variants of concern Viral transmission VoC VOCs younger patient younger patients [DOI] 10.3390/v14071434 PMC 바로가기 [Article Type] Article
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort studySARS-CoV-2의 B.1.1.7(알파) 변이와 비교한 B.1.617.2(델타) 변이로 인한 COVID-19: 전향적 관찰 코호트 연구Observational Study Published on 2022-06-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] 1:1 age Alpha B.1.1.7 B.1.617.2 circulating comparison COVID COVID-19 Delta delta variant disease Dyspnoea Effectiveness Efficacy Fever headache hospital hospitalisation illness illness duration individual individuals Infection positive predominant presenting prospective observational cohort Re-infections reduced regions Reinfection Research risk SARS-CoV-2 SARS-CoV-2 strain Seven sore throat Symptom symptom burden symptomatic adult symptomatic adults Symptoms tested Transmission Vaccine variant variants were assessed [DOI] 10.1038/s41598-022-14016-0 PMC 바로가기 [Article Type] Observational Study
No excess mortality among working-age Italians during the Omicron wave of Covid-19Article Published on 2022-06-282022-11-16 Journal: La Medicina del lavoro [Category] COVID19(2023년), SARS, 변종, [키워드] age caused circulating death defined Delta Delta wave estimate expected individual Italian Italy Mortality mortality data omicron over pandemic Poisson regression models predominant provide reported variant of SARS-CoV-2 were used [DOI] 10.23749/mdl.v113i3.13092 PMC 바로가기
COVID-19 disease severity in US Veterans infected during Omicron and Delta variant predominant periods오미크론 및 델타 변종 우세 기간 동안 감염된 미국 재향 군인의 COVID-19 질병 심각도Article Published on 2022-06-252022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] Cohort Comorbidities COVID-19 disease severity Critical disease Delta delta variant Diagnosis disease severity General population Infection initial less Mild moderate moderate or severe disease Older older subject older subjects omicron Omicron variant performed Population predominant Retrospective analysis SARS-CoV-2 severe disease severity subject the disease thought United State United States vaccination Vaccinations variant veteran veterans [DOI] 10.1038/s41467-022-31402-4 PMC 바로가기 [Article Type] Article
Comparison of temporal evolution of computed tomography imaging features in COVID-19 and influenza infections in a multicenter cohort studyResearch article Published on 2022-06-242022-10-05 Journal: European Journal of Radiology Open [Category] 변종, [키워드] Analysis Chest chronic obstructive pulmonary disease Clinical data Computed tomography consolidation COPDchronic obstructive pulmonary disease coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19coronavirus disease 2019 Critically ill patient CTComputed Tomography Decision tree Diagnosis disease disease course evaluate evaluated Evolution favor feature GGOGround glass opacity ground glass Ground glass opacity haematopoietic stem cell transplantation help HIVhuman immunodeficiency virus HSCTHaematopoietic stem cell transplantation Human immunodeficiency virus ICCIntraclass correlation coefficient ICUIntensive Care Unit identify Inconclusive independent Influenza influenza infection intensive care unit interquartile range Intraclass correlation coefficient IQRinterquartile range Laboratory less lung lung involvement multicenter multicenter cohort study patients PCRpolymerase chain reaction polymerase chain reaction Predictive predominant Result retrospective SDStandard deviation solid organ transplantation SOTSolid organ transplantation Standard deviation was performed [DOI] 10.1016/j.ejro.2022.100431 [Article Type] Research article