Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)과염증 상태의 COVID-19 환자에 대한 토실리주맙 또는 코르티코스테로이드 치료: 다기관 코호트 연구(SAM-COVID-19)Multicenter Study Published on 2021-02-012022-09-12 Journal: Clinical microbiology and infection : the official [Category] MERS, 진단, 치료법, [키워드] 95%CI Analysis association calculated cohort study combination therapy confounders coronavirus disease Corticosteroid Corticosteroids COVID-19 COVID-19 patient Cox regression death dose Follow-up hazard ratio hospital Hyperinflammatory hyperinflammatory state intubation laboratory data Laboratory parameters Logistic regression Mortality multicentre not significant occurred Odds ratio Other outcome Patient patients treated patients with COVID-19 pDC primary endpoint Probability Propensity score provided pulse randomized trial risk Spanish the primary endpoint Tocilizumab Treatment untreated patients variable was performed were used [DOI] 10.1016/j.cmi.2020.08.010 PMC 바로가기 [Article Type] Multicenter Study
Repurposed Tocilizumab in Patients with Severe COVID-19중증 COVID-19 환자의 용도 변경 TocilizumabObservational Study Published on 2021-02-012022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] MERS, SARS, 신약개발, 임상, 진단, 치료기술, [키워드] 95% confidence interval activated activated partial thromboplastin time acute respiratory distress acute respiratory distress syndrome age aggravate C-reactive protein caused Comorbidities Comorbidity Controlled clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokine release syndrome Cytokine storms Disease progression dysregulated Effectiveness elevated Evidence fibrinogen global pandemic hazard ratio IL-6 Immune cell immune cells In-hospital death Inflammation inhibitor inhibitor of IL-6 lower risk morbidity and mortality Observational cohort study Odds ratio partial thromboplastin time Patient patients with COVID-19 Propensity score provided Randomized receiving respiratory distress Respiratory distress syndrome resulting retrospective risk robust severe COVID-19 severely ill patient severely ill patients Sex survival syndrome the cytokine storm THROMBOPLASTIN Tocilizumab tocilizumab administration Treatment Wuhan Wuhan, China [DOI] 10.4049/jimmunol.2000981 PMC 바로가기 [Article Type] Observational Study
Effectiveness of In-Hospital Cholecalciferol Use on Clinical Outcomes in Comorbid COVID-19 Patients: A Hypothesis-Generating StudyArticle Published on 2021-01-142022-10-31 Journal: Nutrients [Category] COVID-19, [키워드] administer Administered amplified Analysis benefit cholecalciferol cholecalciferol treatment clinical Clinical characteristics Clinical outcome clinical trial comorbid disease comorbid diseases comorbid patient Comorbidity COVID-19 COVID-19 patients D-dimer level death diagnosis of SARS-CoV-2 died Effect elevated Endpoint explain follow-up period High-dose Hospitalized ICU In-hospital information intensive care Logistic regression analysis Mortality offer oral cholecalciferol outcome over Patient positive predictive power Propensity score receiver operating characteristic receiving Retrospective study significantly smoking transfer transferred treated Treatment Vitamin D vitamin D levels was recorded with COVID-19 [DOI] 10.3390/nu13010219 PMC 바로가기 [Article Type] Article
Efficacy of corticosteroid treatment for hospitalized patients with severe COVID-19: a multicentre study중증 COVID-19로 입원한 환자에 대한 코르티코스테로이드 치료의 효능: 다기관 연구Observational Study Published on 2021-01-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] SARS, 임상, 진단, 치료법, 치료제, [키워드] 30-Day mortality 30-day mortality rate 95% CI 95% confidence interval adjusted odds ratio Admission ambient ARDS arterial partial pressure of oxygen average binomial breath coronavirus disease Coronavirus disease 2019 Corticosteroid corticosteroid therapy corticosteroid treatment Corticosteroids corticosteroids) covariate COVID-19 COVID-19 patients criteria Critically ill critically ill COVID-19 patients defined dose drugs Efficacy evaluated excluded FiO2 fraction Hospital admission Hospitalization hospitalized patient introduced logistic regression model low-dose low-dose corticosteroid low-dose corticosteroids lower risk minute Mortality multicentre multivariable analysis observational study oxygen oxygen saturation partial pressure Patient patients patients with COVID-19 Prednisone primary endpoint Primary outcome Probability Propensity score receiving respiratory rate SARS-CoV-2 severe COVID-19 subgroup analysis the primary endpoint treated Treatment was performed Weighting [DOI] 10.1016/j.cmi.2020.09.014 PMC 바로가기 [Article Type] Observational Study
Impact of prior statin use on clinical outcomes in COVID-19 patients: data from tertiary referral hospitals during COVID-19 pandemic in ItalyClinical Trial Published on 2021-01-012022-10-05 Journal: Journal of clinical lipidology [Category] SARS, 임상, [키워드] 95% CI Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Admission Affect Anti-inflammatory association clinical condition Clinical outcome cohorts Comorbidities Comorbidity complications consecutive patient coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 pandemic COVID-19 prognosis enrolled Evidence favorable effect Hospitalized immunomodulatory property Impact in-hospital mortality increased risk intensive care Italy Logistic regression analysis mechanical ventilation Mortality mortality rates multicenter Noninvasive ventilation outcomes Patient Propensity score reduce respiratory syndrome coronavirus risk of infection score Secondary outcomes severe COVID-19 severe disease severity severity of COVID-19 statin Statin therapy. tertiary referral hospital therapy treated was used [DOI] 10.1016/j.jacl.2020.12.008 PMC 바로가기 [Article Type] Clinical Trial
Statin Use and In-Hospital Mortality in Patients With Diabetes Mellitus and COVID-19Observational Study Published on 2020-12-152022-10-05 Journal: Journal of the American Heart Association [Category] 임상, [키워드] 95% CI addition administration anti-inflammatory effect association attenuate C-reactive protein characterized competing conducted coronavirus disease COVID-19 COVID-19 in patient COVID‐19 cumulative death diabete Diabetes Mellitus event hazard ratio high mortality hospital Hospitalization in-hospital mortality Inflammatory marker interquartile range lower risk Mortality New York Older Patient patients with COVID-19 patients with diabete Probability proinflammatory Propensity score propensity score matching receive reduced Result severity of COVID-19 single center statin survival Treatment Weighting were used with COVID-19 [DOI] 10.1161/JAHA.120.018475 PMC 바로가기 [Article Type] Observational Study
Chinese herbal medicine reduces mortality in patients with severe and critical Coronavirus disease 2019: a retrospective cohort study중국 약초는 2019년 심각하고 치명적인 코로나바이러스 질환 환자의 사망률을 감소시킵니다: 후향적 코호트 연구Article Published on 2020-12-012022-08-31 Journal: Frontiers of medicine [Category] MERS, 치료제, [키워드] 1:1 95% CI a retrospective cohort study age all-cause mortality baseline Chinese CHM clinical variable collected control group coronavirus disease Coronavirus disease 2019 COVID-19 Critical died disease Efficacy evaluate herbal medicine hospital Mortality mortality risk multivariate adjustment no significant differences Odds ratio Patient patients Propensity score propensity score matching proportion reduce reported retrospective cohort retrospective cohort study Retrospective study risk factor Risk factors Seven severe COVID-19 significant difference treat two group two groups was reduced Wuhan [DOI] 10.1007/s11684-020-0813-6 PMC 바로가기 [Article Type] Article
Causal inference methods for small non-randomized studies: Methods and an application in COVID-19소규모 비무작위 연구를 위한 인과 추론 방법: COVID-19의 방법 및 적용Article Published on 2020-12-012022-09-11 Journal: Contemporary clinical trials [Category] SARS, 임상, 치료제, [키워드] Analysis applied approach Causal Causal inference Clinical studies clinical trial Conditioning covariates COVID-19 diagnostics Efficacy Hydroxychloroquine include less limitation non-randomized non-randomized studies Open-label Pandemics patients with COVID-19 pressure Propensity score provided R code Randomized controlled trial reduce replicate risk robust SARS-CoV-2 pandemic Small samples. Treatment trials Vaccines Variation [DOI] 10.1016/j.cct.2020.106213 PMC 바로가기 [Article Type] Article
Ischemic Stroke Occurs Less Frequently in Patients With COVID-19: A Multicenter Cross-Sectional StudyObservational Study Published on 2020-12-012022-10-05 Journal: Stroke [Category] 임상, [키워드] all age groups Analysis association confounder Coronary artery disease coronavirus disease COVID-19 COVID-19 infection cross-sectional detect diagnosed with COVID-19 discharge discharged Epidemic Frequently Healthcare system heart failure identify increase in Infection investigated Ischemic Logistic regression analysis Mortality New York observational studies Occurrence Odds ratio outcome Patient performed positive presenting Propensity score reached regression models rehabilitation robust SARS-CoV-2 Sensitivity analyses state stroke subject Support were used with COVID-19 [DOI] 10.1161/STROKEAHA.120.031217 PMC 바로가기 [Article Type] Observational Study
Outcomes of COVID-19 Patients under Cytotoxic Cancer Chemotherapy in BrazilArticle Published on 2020-11-242022-10-31 Journal: Cancers [Category] COVID-19, [키워드] 95% CI 95% confidence interval analyzed baseline being Brazil cancer patient Chemotherapy Comorbidity COVID-19 COVID-19 cases cytotoxic died drug drug therapy evaluate exploratory Factors hematologic hematological increase increase in increased mortality information inhibitor Mortality multivariate model neoplasm Neoplasms Odds ratio outcome palliative intent Patient patients performed Propensity score Protective receive retrospective Retrospective analysis risk Risk factors risk of death simple tested Treatment variable with COVID-19 [DOI] 10.3390/cancers12123490 PMC 바로가기 [Article Type] Article