COVID19-related and all-cause mortality risk among middle-aged and older adults across the first epidemic wave of SARS-COV-2 infection: a population-based cohort study in Southern Catalonia, Spain, March–June 2020Research Published on 2021-10-062022-10-28 Journal: BMC Public Health [Category] COVID-19, MERS, SARS, [키워드] 95% confidence interval age all-cause mortality analyses Cancer causes Cohort cohort characteristics cohort study Comorbidity coronavirus COVID-19 COVID-19 pandemic COVID19 Cox regression death deaths Deceased died Direct diuretics epidemic wave explain false negative result First wave greater hazard ratio increased risk Increasing individual inhibitor investigated laboratory-confirmed Liver disease male Mortality mortality rate mortality risk multivariable analysis neurologic occurred Older outcome pandemic Patient patients PCR testing PCR-negative population-based cohort predictor proportion proton-pump inhibitor receiving reduced risk Result risk SARS-CoV-2 Sex significantly socio-demographic Spain study period subject subjects suffered supplementary material systemic corticosteroids underlying conditions were assessed with COVID-19 [DOI] 10.1186/s12889-021-11879-2 PMC 바로가기 [Article Type] Research
In-hospital use of ACE inhibitors/angiotensin receptor blockers associates with COVID-19 outcomes in African American patients아프리카계 미국인 환자의 COVID-19 결과와 관련된 ACE 억제제/안지오텐신 수용체 차단제의 병원 내 사용Clinical Trial Published on 2021-10-012022-09-11 Journal: The Journal of Clinical Investigation [Category] SARS, 유전자 메커니즘, 임상, [키워드] 95% CI ACE ACE inhibitors ACE1 African American African Americans allele angiotensin Angiotensin receptor blockers Angiotensin-converting enzyme ARB association blocker cardiovascular cardiovascular disease coronavirus disease Coronavirus disease 2019 COVID-19 drug drug therapy Epidemiology evaluated hospital improved mortality In-hospital in-hospital mortality mechanism medication Mortality Mount Sinai multivariate logistic regression multivariate logistic regression model New York City outcome Pathogenesis Patient patients with COVID-19 prevalent receptor reduced reduced risk reduction in severe coronavirus disease significantly tested with COVID-19 [DOI] 10.1172/JCI151418 PMC 바로가기 [Article Type] Clinical Trial
Metabolic surgery may protect against admission for COVID-19 in persons with nonalcoholic fatty liver diseaseObservational Study Published on 2021-10-012022-10-05 Journal: Surgery for obesity and related diseases : official journal of the American [Category] SARS, 임상, [키워드] 95% CI 95% confidence interval Adiposity Admission Analysis appear cause chronic inflammation co-morbidities competing COVID-19 COVID-19 diagnosis COVID-19 in patient disease evaluate Factor Fatty liver fatty liver disease Healthcare system Hospitalization Hospitalized include increased risk increased the risk Inflammation Logistic regression medication treatment men metabolic metabolic and bariatric surgery. metabolic disease morbidity and mortality Mortality multiple imputation NAFLD NASH nonalcoholic fatty liver obesity Odds ratio operator Other Patient PCR peptide polymerase chain positive COVID-19 PROTECT receptor reduced risk Research risk risk factor SARS-CoV-2 screened Sex significantly steatohepatitis subgroups syndrome thrombosis Treatment variable selection Venous Thromboembolism visceral was used were assessed were used women [DOI] 10.1016/j.soard.2021.05.029 PMC 바로가기 [Article Type] Observational Study
A cross-sectional study of SARS-CoV-2 seroprevalence among asymptomatic healthcare workers in a tertiary healthcare centre: Assessing the impact of PPE guidelines3차 의료 센터의 무증상 의료 종사자 사이의 SARS-CoV-2 혈청 유병률에 대한 단면 연구: PPE 지침의 영향 평가Article Published on 2021-10-012022-09-11 Journal: Indian journal of medical microbiology [Category] MERS, SARS, 진단, 치료기술, [키워드] Analysis antibodies antibody Assessing Asymptomatic category chemiluminescence Community comparable COVID-19 cross-sectional cross-sectional study demographics demonstrated doctor Efficacy estimate General population groups HCW HCWs healthcare healthcare worker highest IgG antibodies IgG antibody Infection infection control lowest marker much higher Multivariate analysis participant patients PPE questionnaire reduced risk reported risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 seroprevalence Seropositivity Seroprevalence significantly higher significantly lower Spread staff tested transfer were recorded [DOI] 10.1016/j.ijmmb.2021.09.011 PMC 바로가기 [Article Type] Article
Combined anticoagulant and antiplatelet therapy is associated with an improved outcome in hospitalised patients with COVID-19: a propensity matched cohort studyObservational Study Published on 2021-10-012022-10-05 Journal: Open Heart [Category] SARS, 임상, [키워드] 95% CI adjusted Admission all-cause mortality Anticoagulant anticoagulation antiplatelet Antithrombotic clinical cohort study Combined component COVID-19 COVID-19 infection Cox regression analysis disease Efficacy evaluate hospitalised patient ICU ICU admission identify implicated In-hospital in-hospital mortality increase in Infection intensive care Invasive mechanical ventilation less management mechanical ventilation microvascular angina Observational cohort study Occurrence outcome Patient patient population patients with COVID-19 Pharmacology Primary outcome Prophylactic prothrombotic state randomised controlled trial reduced risk Respiratory disease retrospective risk secondary outcome statistically significant difference subgroup TAC therapeutic anticoagulation therapy Thromboembolic events thrombotic treat Treatment university hospital was performed with COVID-19 [DOI] 10.1136/openhrt-2021-001785 PMC 바로가기 [Article Type] Observational Study
Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection증상 및 무증상 SARS-CoV-2 감염에 대한 보호 상관관계Article Published on 2021-09-292022-09-10 Journal: Nature Medicine [Category] MERS, SARS, 변종, 임상, 진단, [키워드] Alpha analyzed Anti-RBD antibodies Anti-spike antibody antibody levels Antibody Units assays asymptomatic infection asymptomatic infections AZD1222 B.1.1.7 binding binding and neutralizing antibodies binding antibody unit binding antibody units can be used ChAdOx1 ChAdOx1 nCoV-19 correlated COVID-19 vaccine COVID-19 vaccines determine Efficacy elicited estimate extrapolation facilitate immune marker immune markers immune response Infectious diseases International international unit majority marker neutralization neutralization titer neutralization titers Neutralizing antibodies neutralizing antibody normalized not correlated Population Predictive pseudovirus Randomized recipients reduced risk SARS-CoV-2 SARS-COV-2 infection second dose significance level symptomatic and asymptomatic symptomatic infection These data Trial United Kingdom Vaccine vaccine efficacy Vaccines variant of SARS-CoV-2 were measured [DOI] 10.1038/s41591-021-01540-1 PMC 바로가기 [Article Type] Article
Calcifediol Treatment and COVID-19-Related OutcomesObservational Study Published on 2021-09-272022-10-05 Journal: The Journal of Clinical Endocrinology and Metaboli [Category] SARS, 임상, [키워드] 25-hydroxyvitamin D 95% CI adjusted Admission age Analysis Barcelona baseline calcifediol calcifediol treatment Comorbidity conducted COVID-19 died Health healthy individuals Hospital admission ICU ICU admission intensive care unit intention-to-treat intention-to-treat analysis Mortality mortality risk Observational cohort study Odds ratio outcome measure outcomes Participants Patient patients hospitalized patients treated patients with COVID-19 Potential treatment reduce reduced reduced risk required severity Sex significantly Spain the disease treated treated patient Treatment Vitamin D were excluded with COVID-19 [DOI] 10.1210/clinem/dgab405 PMC 바로가기 [Article Type] Observational Study
Outpatient and inpatient anticoagulation therapy and the risk for hospital admission and death among COVID-19 patientsResearch Paper Published on 2021-09-242022-10-04 Journal: EClinicalMedicine [Category] 유전자 메커니즘, [키워드] (n), number %, percentage ACEi, angiotensin-converting enzyme inhibitors age anticoagulation ARBs, angiotensin receptor blockers CI, confidence intervals CKD, chronic kidney disease clinics CO2, carbon dioxide COPD, Chronic obstructive pulmonary disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19, Coronavirus disease 2019 D-dimer death deaths diagnosed with COVID-19 Diagnosis DIC, disseminated intravascular coagulation DOAC, direct oral anticoagulant EHR, electronic health records EMR, electronic medical records evaluated failure finding funding HCT, hematocrit HIT, heparin-induced thrombocytopenia hospital Hospital admission Hospitalization Hospitalized hospitalized COVID-19 patient HR, hazard ratio hypercoagulable increased mortality increased risk Inpatient investigated IPAC, inpatient anticoagulation therapy IRB, institutional review board Limited mg/dl, milligram per deciliter MI, prior myocardial infarction Mortality mortality risk multivariable analysis OPAC, outpatient persistent anticoagulation therapy Outpatient outpatients overall case-fatality rate Patient patients prospective cohort study RDW, red blood cell distribution width reduced risk reduction in risk RT-PCR, Reverse transcriptase-polymerase chain reaction SARS-COV-2, severe acute respiratory syndrome coronavirus-2 SBP-min, minimum systolic blood pressure SBP, systolic blood pressure SD, standard deviations SE, standard errors SpO2-min, minimum oxygen saturation T1DM, type 1 diabetes mellitus T2DM, type 2 diabetes mellitus the patient therapy treated USA VTE, venous thromboembolism was obtained WBC, White blood cell with COVID-19 [DOI] 10.1016/j.eclinm.2021.101139 PMC 바로가기 [Article Type] Research Paper
The association of remdesivir and in-hospital outcomes for COVID-19 patients treated with steroids스테로이드 치료를 받은 COVID-19 환자의 렘데시비르와 병원 내 결과의 연관성Multicenter Study Published on 2021-09-152022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] SARS, 치료제, [키워드] 1:1 Acute kidney injury AKI analyses Analysis association conducted COVID-19 COVID-19 antibody COVID-19 patient COVID-19 symptoms creatinine decrease defined discharged Eligible patients Endotracheal intubation evaluated Evidence Hospital mortality In-hospital in-hospital mortality Kidney injury Laboratory medical record medical records Mount Sinai Mount Sinai Health System multicentre outcome Patient patients with COVID-19 propensity score matching Prospective Study reduce reduced risk Remdesivir retrospective risk SARS-CoV-2 viral load SARS-CoV-2 viral loads serum creatinine shown signal significantly steroid steroid treatment Steroids Stratification Subgroup analyses subgroup analysis System treated viral loads [DOI] 10.1093/jac/dkab256 PMC 바로가기 [Article Type] Multicenter Study
Factors Associated With Longitudinal Psychological and Physiological Stress in Health Care Workers During the COVID-19 Pandemic: Observational Study Using Apple Watch DataObservational Study Published on 2021-09-132022-10-04 Journal: Journal of Medical Internet Research [Category] SARS, 임상, [키워드] A significant reduction age Analysis app Apple Watch autonomic baseline changes in Characteristics collected COVID-19 COVID-19 case COVID-19 diagnosis COVID-19 pandemic determine Effect emotion emotional enrolled Factor feature follow-up period HCW HCWs Health care worker heart rate heart rate variability highest hospital HRV identify increased risk individual longitudinal marker medium mental health Multivariate analysis nervous system nervous system function New York New York City objective Observational optimism pandemic participant Perceived stress physiological physiological consequence Physiology Protective Psychological Psychological distress Psychology Quality of life reduced risk Resilience Result risk significantly Stress Stressor subject Support survey Variability Warrior wearable device worker [DOI] 10.2196/31295 PMC 바로가기 [Article Type] Observational Study