Repurposed drug – Page 9 – Communicable Diseases Research

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

TMPRSS2 발현에 대한 독특한 메커니즘은 엔잘루타미드에 의한 SARS-CoV-2 감염의 기관 특이적 억제를 설명합니다

Article

Published on 2021-02-082022-09-10
Journal: Nature Communications [Category] MERS, 신약개발, 유전자 메커니즘, 진단, 치료제,

Identification of antiviral antihistamines for COVID-19 repurposing

COVID-19 용도 변경을 위한 항바이러스성 항히스타민제 식별

Article

Published on 2021-01-292022-08-31
Journal: Biochemical and Biophysical Research Communication [Category] SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] ACE2 adjuvant therapy age angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 Antihistamine Antihistamines Antiviral antiviral activity Antiviral effect antiviral effects approved drug approved drugs azelastine benefit candidate clinical Clinical studies COVID-19 COVID-19 patients diphenhydramine disease docking Effectiveness Electronic health record Electronic health records enzyme greater Histamine hydroxyzine identification identify IMPROVE in vitro in vitro activity incidence Intervention ligands mechanism outcome Prevent receptor Receptor binding reduced Repurposed drug Repurposed drugs repurposing safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positivity severe COVID-19 sigma sigma-1 receptor subject tested therapy Treatment Usage
[DOI] 10.1016/j.bbrc.2020.11.095 PMC 바로가기 [Article Type] Article

Virtual screening of phytochemical compounds as potential inhibitors against SARS-CoV-2 infection

Research

Published on 2021-01-282022-10-28
Journal: Beni-Suef University Journal of Basic and Applied Sciences [Category] COVID-19,

[키워드] acute respiratory illness ADME Analysis antiretroviral drugs binding Cell Compound coronavirus Coronavirus infection death diagnosed diagnostic docking drug drugs effective inhibitor Efficacy GRP78 H-bond highest Host hydrophilicity hydrophobic identify in silico drug design In silico method India Infection inhibit inhibitor Interaction Molecular docking study pandemic performed permeation Physicochemical properties receptor Repurposed drug residue Result Retroviral infection reveal S-protein Safe SARS-COV-2 infection screened Side-effect supplementary material surface receptor Toxicity treated Treatment Virtual screening virus Western Ghats
[DOI] 10.1186/s43088-021-00095-x PMC 바로가기 [Article Type] Research

Interactions of Potential Anti-COVID-19 Compounds with Multispecific ABC and OATP Drug Transporters

Article

Published on 2021-01-092022-10-28
Journal: Pharmaceutics [Category] COVID-19,

Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2

Research Article

Published on 2021-01-072022-10-27
Journal: BMC Medical Informatics and Decision Making [Category] COVID-19,

[키워드] activated addition affected Analysis approach caused clinical trials coronavirus 2 COVID-19 COVID-19 patient Critical Data analysis death rate Dexamethasone drug drug-target effective effective drug epithelial cell ERK evaluated facilitate Gene Expression high mortality rate host cell host cells human lung identify immune Infection Integrative analysis involved Jak-STAT JNK MAPK molecular Ontology pandemic pathway receiving reduce reported Repurposed drug resources respiratory Respiratory Support Result SARS-CoV-2 Signaling signaling pathway significantly STAT therapy transcriptional response Treatment treatments for COVID-19 Vaccine
[DOI] 10.1186/s12911-020-01373-x PMC 바로가기 [Article Type] Research Article

Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2

Research Article

Published on 2021-01-072022-10-27
Journal: BMC Medical Informatics and Decision Making [Category] Coronavirus, COVID-19,

[키워드] activated addition affected Analysis approach caused clinical trials coronavirus 2 COVID-19 COVID-19 patient Critical Data analysis death rate Dexamethasone drug drug-target effective effective drug epithelial cell ERK evaluated facilitate Gene Expression high mortality rate host cell host cells human lung identify immune Infection Integrative analysis involved Jak-STAT JNK MAPK molecular Ontology pandemic pathway receiving reduce reported Repurposed drug resources respiratory Respiratory Support Result SARS-CoV-2 Signaling signaling pathway significantly STAT therapy transcriptional response Treatment treatments for COVID-19 Vaccine
[DOI] 10.1186/s12911-020-01373-x PMC 바로가기 [Article Type] Research Article

Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2

SARS-CoV-2에 대한 숙주 세포의 전사 반응을 기반으로 COVID-19에 대한 약물 용도 변경을 위한 전산 분석

Research Article

Published on 2021-01-072022-09-10
Journal: BMC Medical Informatics and Decision Making [Category] 신약개발, 유전자 메커니즘, 치료제,

[키워드] activated addition affected Analysis approach caused clinical trials coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 treatment Critical CXCR6 Data analysis death rate Dexamethasone drug drug-target effective effective drug effective drugs epithelial cell epithelial cells ERK evaluated facilitate Gene Expression high mortality rate host cell host cells human lung human lung epithelial cells identify immune Infection Integrative analysis involved IRF7 Jak-STAT JNK life cycle MAPK molecular MYD88 NFkB Ontology pandemic pathway Pathways receiving reduce reported Repurposed drug Repurposed drugs resources respiratory Respiratory Support Result SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling signaling pathway signaling pathways significantly STAT therapy transcriptional response Treatment treatments for COVID-19 Vaccine
[DOI] 10.1186/s12911-020-01373-x PMC 바로가기 [Article Type] Research Article

COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges

COVID-19와 암 동반질환: 치료의 기회와 도전

Review

Published on 2021-01-012022-09-10
Journal: Theranostics [Category] MERS, 신약개발,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect age anticancer approach Cancer cancer patient Cancer patients Care caused challenge choice Comorbidity confirmed cases coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses cough COVID-19 COVID-19 outbreak COVID-19 pandemic death disease disease severity Genome globe higher risk hospital Human Immunity individual infected individuals Infection Inflammation multidisciplinary approach Numerous opportunity pandemic pathophysiology Pathways produced reported Repurposed drug Repurposed drugs respiratory respiratory droplet Respiratory droplets Respiratory system risk SARS-CoV-2 SARS-CoV-2 pandemic signaling pathway sneezes Spread the SARS-CoV-2 treating COVID-19 Treatment viral disease Wuhan Wuhan, China
[DOI] 10.7150/thno.51471 PMC 바로가기 [Article Type] Review

Computational drug discovery and repurposing for the treatment of COVID-19: A systematic review

COVID-19 치료를 위한 컴퓨터 약물 발견 및 용도 변경: 체계적인 검토

Article

Published on 2021-01-012022-08-31
Journal: Bioorganic chemistry [Category] SARS, 신약개발, 유전자 메커니즘, 치료법, 치료제,

[키워드] AIDS Analysis Anticoagulant anticoagulant drug antiviral drug antiviral drugs applied approved approved drug approved drugs article asunaprevir Atazanavir AutoDock AutoDock vina best boceprevir Chloroquine clinical evidence clinical study Clocortolone CMV Computational drug computational method Computational methods COVID-19 COVID-19 progression COVID-19 therapy COVID-2019 crystal structure Dabigatran darunavir database disease disease outbreak docking tool dolutegravir drug Drug discovery Drug repurposing drugs Ebola efavirenz Efficacy eligible English entecavir FIVE formoterol Future Ganciclovir Grazoprevir HBV HCV Indinavir inhibit itraconazole life-threatening list Lomibuvir Lopinavir majority matter mechanism molecular mycophenolic acid nelfinavir non-structural protein non-structural proteins Novel coronavirus occurred offer outbreak Papain Papain-like protease Penciclovir protease provide raltegravir Remdesivir Repurposed drug Repurposed drugs ribavirin Ritonavir RNA-dependent RNA polymerase saquinavir SARS-CoV-2 SARS-CoV2 sequence Simeprevir systematic review telaprevir the disease therapeutic therapy treat Treatment treatment of COVID-19
[DOI] 10.1016/j.bioorg.2020.104490 PMC 바로가기 [Article Type] Article

Recent Progress in the Drug Development Targeting SARS-CoV-2 Main Protease as Treatment for COVID-19

Molecular Biosciences

Published on 2020-12-042022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,