Investigating the structure-activity relationship of marine polycyclic batzelladine alkaloids as promising inhibitors for SARS-CoV-2 main protease (M pro)SARS-CoV-2 주요 프로테아제(M pro)의 유망한 억제제로서 해양 다환식 batzelladine 알칼로이드의 구조-활성 관계 조사Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] active sites antiviral therapeutics antivirals approved Batzelladines binding affinity China Compound computational tool drugs effective examined feature form fused guanidine Guanidine alkaloids H-I Health highlighting inhibitor investigated M pro Marine sponges MD simulation medications molecular docking molecular dynamics Novel coronavirus over pandemic polycyclic position primary source protease protein-ligand interaction residues SAR SARS SARS-CoV-2 SARS-CoV-2 main protease side chain spacer span stability the SARS-CoV-2 unsaturation Vaccine variants Virtual screening virus [DOI] 10.1016/j.compbiomed.2022.105738 PMC 바로가기 [Article Type] Article
Piezoelectric point-of-care biosensor for the detection of SARS-COV-2 (COVID-19) antibodiesResearch article Published on 2022-08-012022-10-05 Journal: Sensing and Bio-Sensing Research [Category] 진단, 치료기술, [키워드] analyzed antibodies antibody Antigen assays caused changes COVID-19 diagnose diagnostic diagnostics different disease disease facilitate faster feature Frequency global pandemic high mortality In-vitro Novel coronavirus Piezoelectric biosensor platform POC biosensor point-of-care resulting SARS SAW selective sensitivity sensor specific disease Surface acoustic waves tested the disease the vaccine Vaccine development [DOI] 10.1016/j.sbsr.2022.100510 [Article Type] Research article
Transmissibility of SARS-CoV-2 B.1.1.214 and Alpha Variants during 4 COVID-19 Waves, Kyoto, Japan, January 2020-June 20212020년 1월-2021년 6월 일본 교토, 4개의 COVID-19 파도 동안 SARS-CoV-2 B.1.1.214 및 알파 변이의 전염성Article Published on 2022-08-012022-09-11 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha variant city close contact collected Contact Contact tracing coronavirus coronavirus disease COVID-19 COVID-19 case Epidemiology evaluate the effect Health help highest household household contact household contacts household transmission Households Intervention Japan Kyoto Lineage Odds ratio prevalent primary source proportion Public Public health interventions respiratory infections reverse transcription PCR SARS SARS-CoV-2 SARS-CoV-2 transmission secondary case secondary cases severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly Spread Transmission variant viral genome viral genome analysis viral strain viral strains viruses zoonoses [DOI] 10.3201/eid2808.220420 PMC 바로가기 [Article Type] Article
Persistent blood DNA methylation changes one year after SARS-CoV-2 infectionArticle Published on 2022-07-232023-07-10 Journal: Clinical Epigenetics [Category] COVID19(2023년), [키워드] COVID-19 DNA methylation PASC SARS [DOI] 10.1186/s13148-022-01313-8 PMC 바로가기
Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into CellsSARS-CoV-2 세포로의 진입을 완전히 차단하려면 Vacuolar-ATPase 및 TMPRSS2의 이중 억제가 필요합니다Article Published on 2022-07-192022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] absence Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ATPase bafilomycin block viral entry camostat cathepsin inhibitor Cathepsins Cell cellular Compound coronavirus E64d Efficacy endosomal pH endosomal protease endosome expressing highlight host cell host protease host proteases Hydroxychloroquine identify implicated Infection inhibit inhibiting inhibition inhibitor inhibitors Intervention life cycle Macrolide maturation mechanisms membrane fusion molecules Neutralizing nonspecific Pathways pharmacological agent Prevent protease Protein proteolytic activation provide pseudotyped rationale S protein SARS SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Serine serine 2 serine proteases severe acute respiratory syndrome Coronavirus synergy the S protein these compound these compounds TMPRSS2 TMPRSS2 inhibitor TMPRSS2-expressing cells toxicities Toxicity transmembrane V-ATPase viral entry viral spike virus [DOI] 10.1128/aac.00439-22 PMC 바로가기 [Article Type] Article
Comparison of clinical characteristics and outcomes of hospitalized patients with seasonal coronavirus infection and COVID-19: a retrospective cohort studyArticle Published on 2022-07-152023-07-10 Journal: BMC Infectious Diseases [Category] COVID19(2023년), [키워드] COVID-19 human coronavirus MERS SARS seasonal coronavirus [DOI] 10.1186/s12879-022-07555-4 PMC 바로가기
Long COVID and its ManagementReview Published on 2022-07-112022-10-04 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 신약개발, [키워드] accumulated Complication COVID COVID-19 diagnostic Drug repurposing Health Infection knowledge Long Long COVID management pandemic of COVID-19 Patient post-acute COVID syndrome (PACS) post-acute sequelae of SARS-CoV-2 (PASC) professional public health crisis resource risk risk factor Risk factors SARS SARS-CoV-2 Symptom syndrome Vaccine while with COVID-19 [DOI] 10.7150/ijbs.75056 PMC 바로가기 [Article Type] Review
The COVID-19 pandemic – How many times were we warned before?Review article Published on 2022-07-012022-10-05 Journal: European journal of internal medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome caused consequence coronavirus coronavirus disease Coronaviruses COVID-19 COVID-19 pandemic disease Diseases emerging disease Epidemics evaluate indicated MERS MERS-CoV Middle East outbreak Outbreaks pandemic of COVID-19 Pandemics pathogen predicted researcher respiratory syndrome coronavirus SARS SARS-CoV SARS-CoV-2 Taking the WHO while WHO World Health Organization [DOI] 10.1016/j.ejim.2022.07.009 [Article Type] Review article
One-year persistent symptoms and functional impairment in SARS-CoV-2 positive and negative individualsArticle Published on 2022-07-012023-07-09 Journal: Journal of internal medicine [Category] COVID19(2023년), [키워드] Epidemiology Functional impairment Infectious diseases Inflammation internal medicine persistent symptoms Post-COVID SARS [DOI] 10.1111/joim.13482 PMC 바로가기
Measuring Basic Reproduction Number to Assess Effects of Nonpharmaceutical Interventions on Nosocomial SARS-CoV-2 TransmissionArticle Published on 2022-07-012023-07-09 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), [키워드] basic reproduction number contact precautions coronavirus coronavirus disease COVID-19 iterative filtering Long-term care facility Nosocomial infection patient-to-patient transmission R0 respiratory infections SARS SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 statistical inference Stochastic modelling transmission rate viruses zoonoses [DOI] 10.3201/eid2807.212339 PMC 바로가기