A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures
Research
[키워드] ACE2
acute respiratory syndrome
administration
angiotensin-converting enzyme 2
animal model
BALB/c mice
caused
cells
Clinical use
clinically
coronavirus
coronavirus disease
COVID-19
demonstrated
disease pathogenesis
epithelial cell
exhibited
Express
expression
Host
Human
human ACE2
inefficient
infect
inhibit
Interaction
Laboratory
lower airway
mice
mouse-adapted SARS-CoV-2
orthologue
phenotype
primary human airway
promoter
Prophylactic
receptor
replicate
SARS-CoV-2
SARS-CoV-2 disease
SARS-CoV-2 replication
SARS-CoV-2 spike protein
severe disease
spread to
Support
therapeutic
transgenic mice
Transmission
Treatment
utility
viral spike protein
virus
wild-type
[DOI] 10.1038/s41586-020-2708-8 [Article Type] Research
[DOI] 10.1038/s41586-020-2708-8 [Article Type] Research