SARS-CoV-2 pathogenesis – Page 9 – Communicable Diseases Research

Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell-Derived Intestinal Organoids

인간 만능 줄기 세포 유래 장 오르가노이드에서 SARS-CoV-2 복제의 약물 억제

Article

Published on 2021-01-012022-09-12
Journal: Cellular and molecular gastroenterology and hepato [Category] SARS, 진단,

mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2

중증 급성 호흡기 증후군 코로나바이러스 2에 대한 적응 면역 반응 연구를 위해 쥐에서 mRNA 유도 인간 안지오텐신 전환 효소 2 발현

Research Article

Published on 2020-12-162022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 치료법,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model Antigen Antiviral Author caused CD4+ CD4+ T cell CD8+ CD8+ T cell cells cloned coronavirus Critical demonstrated Efficacy entry of SARS-CoV-2 Epitopes expressed expression functional hACE2 hACE2 receptor human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human coronavirus humans immune response in vivo induce Infection information interferon receptor Laboratory lack membrane Membrane proteins memory mice mRNA mRNA expression mRNA transfection mRNA-based murine murine model murine models nucleocapsid pandemic peptide peptide epitope peptides preserved provided receptor Replication required respiratory response SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pathogenesis Secondary infection severe acute respiratory syndrome Coronavirus Spike proteins strain T cell T cell epitope T cell epitopes T cell response T cells this system type 1 interferon unique Vaccine vaccine efficacy Vaccines virus
[DOI] 10.1371/journal.ppat.1009163 PMC 바로가기 [Article Type] Research Article

Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses

Observation

Published on 2020-12-112022-10-29
Journal: mBio [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 expression ACE2 receptor activate activating acute respiratory distress Affect alveolar angiotensin-converting enzyme 2 ARDS Brain cause characterized ciliated epithelial cell Coagulation Coagulopathy COVID-19 COVID-19 patient COVID-19 patients Critical Diffuse alveolar damage dysfunction dysregulated edema elicit Endothelial cell endothelial cells Endotheliitis Endothelium epithelial explain function Gas exchange hemorrhage Human indicate infect infecting Infection Inflammation Inflammatory response kidney tissues lack Multiorgan dysfunction occur progressive respiratory failure Protein pulmonary Pulmonary edema pulmonary epithelial cell receptor recombinant recombinant ACE2 regulate Regulation resolved response responses resulting RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis Syncytia syndrome therapeutic targets thrombosis transduced umbilical upper respiratory tract Vascular Vascular function Viral pneumonia viral titer
[DOI] 10.1128/mBio.03185-20 PMC 바로가기 [Article Type] Observation

Mechanisms of Dysregulated Humoral and Cellular Immunity by SARS-CoV-2

Review

Published on 2020-12-082022-10-28
Journal: Pathogens [Category] COVID-19,

Pervasive generation of non-canonical subgenomic RNAs by SARS-CoV-2

SARS-CoV-2에 의한 비정규 서브게놈 RNA의 광범위한 생성

Research

Published on 2020-12-012022-08-13
Journal: Genome Medicine [Category] MERS, SARS, 유전자 메커니즘,

[키워드] 3′ end 5′ UTR abundance accessory protein addition Analysis approaches canonical canonical sgRNA canonical sgRNAs caused Cell culture condition Consistency Coordinate coronavirus disease Coronavirus disease 2019 Coverage COVID-19 determine Direct RNA sequencing eight Evidence family Coronaviridae FIVE generate Genome highlight homology Host identify in viral increase in independent Infection information Integrative analysis junction landscape leader sequence make up nc-sgRNA nc-sgRNAs non-canonical sgRNA non-canonical sgRNAs non-canonical subgenomic RNA offer open reading frames ORF ORF1a ORFs positive-sense RNA virus Region reported Result RNA RNA virus SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 genome SARS-CoV-2 pathogenesis SARS-CoV-2 RNA SARS-CoV-2 sgRNA SARS-CoV-2 sgRNAs SARS-CoV-2 transcriptome SARS-CoV-2 transcriptomes sequence sequences Sequencing Seven sgRNA sgRNAs subgenomic RNA subgenomic RNAs supplementary material the SARS-CoV-2 genome Transcription transcriptional activity transcriptional regulatory sequence transcriptional regulatory sequences transcriptomes TRS TRS-B TRS-L Viral viral isolate viral isolates viral RNAs was used worldwide pandemic
[DOI] 10.1186/s13073-020-00802-w PMC 바로가기 [Article Type] Research

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

SARS-CoV-2는 호스트 방어를 억제하기 위해 스플라이싱, 번역 및 단백질 트래피킹을 방해합니다.

Article

Published on 2020-11-252022-09-11
Journal: Cell [Category] MERS, SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus bind cause cell membrane cellular cellular processe coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disrupt Disruption domain engage function Host host defenses Infection Interaction interfere interferon interferon response leads molecular basis mRNA mRNA splicing mRNA translation nsp1 nsp16 NSP8 Nsp9 Protein protein trafficking protein translation respiratory Respiratory disease ribosomal RNA ribosome RNA RNA-protein interactions RNAs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 snRNA splicing suppress the cell the interferon translation Viral viral infection
[DOI] 10.1016/j.cell.2020.10.004 PMC 바로가기 [Article Type] Article

In silico studies evidenced the role of structurally diverse plant secondary metabolites in reducing SARS-CoV-2 pathogenesis

In silico 연구는 SARS-CoV-2 발병기전을 감소시키는 구조적으로 다양한 식물 2차 대사산물의 역할을 입증했습니다.

Article

Published on 2020-11-252022-08-31
Journal: Scientific Reports [Category] SARS, 신약개발, 치료제,

[키워드] active site anthocyanidins anti-SARS-CoV-2 binding Bioavailability Computational biology and bioinformatics COVID-19 Data analysis Drug discovery drug-likeness enzyme Enzymes evidenced flavonoids flavonol glycoside host cell in vitro in vivo Interaction Ligand lower binding energy molecular docking natural Occurrence plant plants platform present protease Protein provide PSM Receptor binding domain recorded reducing Replication researcher Result RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 pathogenesis Secondary Metabolite secondary metabolites selected Serine silico study small molecule Small molecules target proteins transformation transmembrane serine protease unique Viral viral pathogenesis Viral RNA viral RNA-dependent RNA polymerase viral spike viral spike protein
[DOI] 10.1038/s41598-020-77602-0 PMC 바로가기 [Article Type] Article

Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

SARS-CoV-2에 감염된 붉은털 원숭이의 혈관 질환 및 혈전증

Case Reports

Published on 2020-11-252022-09-11
Journal: Cell [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] Analysis Bronchoalveolar lavage C-reactive protein clinical Clinical features Coagulation collagen complement COVID-19 COVID-19 pandemic Critical endothelial feature Human IFNα IL-1 IL-6 IL-8 include infected with SARS-CoV-2 Inflammation Inflammatory Interaction lead lung Lungs macaque macaques Macrophage molecular morbidity and mortality MX1 NF-κB pathway performed Peripheral blood Platelet platelet activation potential therapeutic target potential therapeutic targets proinflammatory proteomic rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 pathogenesis serum thrombosis TNFα transcriptomic Transcriptomic analyses upregulation Vascular vascular disease vascular thrombosis vWF
[DOI] 10.1016/j.cell.2020.10.005 PMC 바로가기 [Article Type] Case Reports

Conserved Genomic Terminals of SARS-CoV-2 as Coevolving Functional Elements and Potential Therapeutic Targets

공진화 기능 요소 및 잠재적 치료 표적으로서 SARS-CoV-2의 보존된 게놈 말단

Research Article

Published on 2020-11-252022-09-10
Journal: mSphere [Category] SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] 3′ untranslated region 3′-UTR acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis Animal coronaviruses antiviral drug antiviral drugs Betacoronavirus complex conserved contribute coronavirus coronavirus disease Coronavirus disease 2019 coronavirus genomes CoV COVID-19 death deaths disease disease outbreak Economy Effect effort element ENhance Evidence Factor feature function Genome H1N1 H1N1 virus Host Host immune response human host human microRNA identify Infection Infectious disease infectious disease outbreak Influenza influenza A Influenza A H1N1 influenza A virus Interaction investigated leads Lineage mechanism microRNA multiple group multiple groups Mutation outbreak pathogenicity phylogenetically Potential public health respiratory responsible SARS-CoV SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genome sequence SARS-CoV-2 pathogenesis SARS-CoV-2 replication SARS-CoV-2 strain sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarity survival target targets terminal the SARS-CoV-2 the SARS-CoV-2 genome therapeutic target therapeutic targets unique untranslated region Vaccine Variation Viral viral replication virus 3′ untranslated region weakened
[DOI] 10.1128/mSphere.00754-20 PMC 바로가기 [Article Type] Research Article

In silico and in vitro studies reveal complement system drives coagulation cascade in SARS-CoV-2 pathogenesis

Research Article

Published on 2020-11-112022-10-31
Journal: Computational and Structural Biotechnology Journal [Category] COVID-19,

[키워드] Abstract AKT1 Analysis approach ARDS Cancer candidate cascades Cell changes Coagulation coagulation cascade complement Complication computational analysis COVID-19 Critical Critical case Cytokines storm degranulation degree downstream driver expression Fold change Gene ontology globe host proteins Huh7 IFN-I in silico in vitro in vitro study include Infection inhibit intravascular coagulation IRAK1 IRF3 IRF7 ISG ITGAM KEGG pathway analysis knowledge lack MAPK signaling MAPK1 MAPK1/MAPK3 MAPK3 MAVS mechanism medical intervention mitigate MOST neutrophil degranulation overlap pathway Pathways PD-L1 platelet activation predicted Protein proteomic public health emergency receptor signaling Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis severe COVID-19 patients Signaling signaling pathway similarity Spread SRC STOM therapeutic targeting thrombosis thrombotic TNF TP53 Traf6 Transcriptome up-regulated VAMP8 viral infection viral pathogenesis
[DOI] 10.1016/j.csbj.2020.11.005 PMC 바로가기 [Article Type] Research Article