RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses: a first lookBioinformatics Published on 2020-08-012022-10-29 Journal: RNA (New York, N.Y.) [Category] COVID-19, SARS, [키워드] 3′ UTR 5′ UTR Antiviral betacoronaviruses Complete conservation conserved COVID-19 outbreak curated diagnostic diagnostics element genome region genome regions genome sequence genomic region majority ncRNA predict Region regions reported Rfam RNA RNA genome RNA secondary structure RNA sequence SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 strains secondary structure sequence spreads structurome target the SARS-CoV-2 the SARS-CoV-2 genome the SARS-CoV-2 virus viral genome [DOI] 10.1261/rna.076141.120 PMC 바로가기 [Article Type] Bioinformatics
The Enigma of Low COVID-19 Fatality Rate in India인도의 낮은 COVID-19 치사율의 수수께끼Genetics Published on 2020-07-282022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] ACE2 receptors acute respiratory syndrome coronavirus Alter angiotensin converting enzyme 2 average BCG vaccination Betacoronavirus caused circulating city coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 death environmental factor environmental factors Epigenetic evidenced Factor Factors Fatality rate genetic diversity Genetic polymorphism genetic polymorphisms Guangdong Health Organization high temperature Host Humidity hypothese ICU admission immune responses include India Indian population Innate immunity killer cell immunoglobulin-like receptors less lowest mechanical ventilation micro RNA microRNA Mutation offer pandemic pathogen Perspective Pneumonia Rate reducing reported respiratory responsible SARS-CoV-2 SARS-CoV-2 strains severity strain susceptibility the disease Transmissibility Transmission viability virulence virus WHO World Health Organization Wuhan [DOI] 10.3389/fgene.2020.00854 PMC 바로가기 [Article Type] Genetics
Understanding genomic diversity, pan-genome, and evolution of SARS-CoV-2Bioinformatics Published on 2020-07-172022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] Analysis analyzed ancestor bat bioinformatics contributed coronavirus CoV COVID-19 Diagnosis disease Epidemiology Evolution Evolution of SARS-CoV-2 Genome genome organization genomic Genomics genus Betacoronavirus help homology hosts indicate Infection isolate isolates majority medium mutational hotspot mutations novel virus pandemic pangolin pathogenicity Phylogeny predicted Probability respiratory SARS SARS-CoV SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains sequenced the SARS-CoV-2 genome Treatment understanding unique viral disease Wuhan, China [DOI] 10.7717/peerj.9576 PMC 바로가기 [Article Type] Bioinformatics
A Novel Synonymous Mutation of SARS-CoV-2: Is This Possible to Affect Their Antigenicity and Immunogenicity?Brief Report Published on 2020-05-142022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] analyzed antigenic antigenicity B-cell epitope Characteristics coronavirus COVID-19 D614G effective evade Evolution of SARS-CoV-2 exhibited host immune system Mutation novel Pathogenesis Phylogenetic analysis Prevent reduced required S gene S glycoprotein S1 domain SARS-CoV-2 SARS-CoV-2 strains sequence serological Spike protein strain subtype Subtypes synonymous Vaccine viral entry virus [DOI] 10.3390/vaccines8020220 PMC 바로가기 [Article Type] Brief Report
Development of an inactivated vaccine candidate for SARS-CoV-2SARS-CoV-2 불활화백신 후보물질 개발Report Published on 2020-05-062022-09-14 Journal: Science (New York, N.y.) [Category] MERS, SARS, 비임상, 진단, [키워드] antibody Antibody-dependent enhancement caused clinical development Complete coronavirus disease COVID-19 development different dose dose effective vaccine humans immunization inactivated Inactivated vaccine Infection macaque mice neutralized Neutralizing non-human primates pandemic PiCoVacc provided public health crisis purified SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 vaccine SARS-CoV-2 virus SARS-CoV-2-specific neutralizing antibody Support Treatment Vaccine vaccine candidate virus [DOI] 10.1126/science.abc1932 PMC 바로가기 [Article Type] Report
SARS-CoV-2 and ORF3a: Nonsynonymous Mutations, Functional Domains, and Viral PathogenesisObservation Published on 2020-05-052022-10-29 Journal: mSystems [Category] COVID-19, [키워드] 3a protein acute respiratory syndrome amino acid substitution Analysis conserved coronavirus coronavirus disease COVID-19 defined disease pathogenesis domain functional isolate nonsynonymous nonsynonymous mutation Nonsynonymous mutations observation ORF3a orf3a gene pandemic Pathogenesis Protein reported SARS-CoV SARS-CoV-2 SARS-CoV-2 strains subpopulations the SARS-CoV-2 unique viral life cycle virulence virus [DOI] 10.1128/mSystems.00266-20 PMC 바로가기 [Article Type] Observation