Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling
푸린 절단 부위의 획득 및 추가 SARS-CoV-2 진화는 바이러스 진입, 감염 확산 및 세포 신호 전달의 메커니즘을 변경합니다
Article
[키워드] ACE2
acquisition
activate
activating
Activation
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
Adaptive immune response
alphavirus
appear
cathepsin
Cathepsins
Cell
Cell fusion
change
coronavirus
COVID
COVID-19 disease
Cytokines
Deletion
determined by
endosome
Entry mechanism
entry pathway
Evolution
experimental system
expressing S protein
expression
FCS
furin
furin cleavage
furin cleavage site
hallmark
human population
immune
in vitro
induce
infected with SARS-CoV-2
infecting
Infection
inhibitor
inhibitors
lack
leads
Lineage
mAbs
mechanism
media
mRNA vaccines
Neutralizing
neutralizing monoclonal antibodies
neutralizing monoclonal antibody
pro-inflammatory cytokines
pro-inflammatory response
pseudoinfectious viruses
pseudovirus
pseudoviruses
receptor
released
respiratory
S protein
S1 secretion
S1 subunit
SARS-CoV-2
SARS-CoV-2 pathogenesis
SARS-CoV-2 S protein
secrete
sera
severe acute respiratory syndrome Coronavirus
shown
Site
Spike protein
Spread
spreading
Syncytia
syncytium
syncytium formation
the S protein
the S1 subunit
TLR4
TMPRSS2
TMPRSS2 expression
variant
Viral
viral evolution
virus
virus entry
virus spread
[DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article
[DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article