serine 2 – Page 9 – Communicable Diseases Research

Host genomics of COVID-19: Evidence point towards Alpha 1 antitrypsin deficiency as a putative risk factor for higher mortality rate

Research article

Published on 2021-02-012022-10-05
Journal: Medical Hypotheses [Category] 유전자 메커니즘,

Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial (EAT-DUTA AndroCoV Trial – Biochemical)

Endocrinology/Diabetes/Metabolism

Published on 2021-02-012022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] 24 hour acute respiratory syndrome AGA Analysis androgen Anosmia antagonist antiandrogen Azithromycin benefit biochemical C-reactive protein cell entry clinical recovery clinics conducted coronavirus COVID-19 COVID-19 disease severity D-dimer Day demonstrated determine disease dutasteride erythrocyte sedimentation rate ESR fatigue FIVE Inflammatory marker inhibitor Lactate LDH male median Mild mild COVID-19 symptom moderate nitazoxanide oxygen saturation participant Placebo positive protease receptor recruitment reduce reduced Regulation Result SARS-CoV-2 serine 2 Seven severe coronavirus disease shedding Standard therapy subject subsequent Symptoms the placebo group therapy transmembrane treated Treatment treatment for COVID-19 troponin level viral shedding were given
[DOI] 10.7759/cureus.13047 PMC 바로가기 [Article Type] Endocrinology/Diabetes/Metabolism

Significance of NETs Formation in COVID-19

Review

Published on 2021-01-142022-10-31
Journal: Cells [Category] COVID-19,

[키워드] ACE2 base cellular combating contagious coronavirus Course COVID-19 COVID-19 in patient COVID-19 pathogenesis elevated enzyme excessive inflammatory response Extracellular Formation IMPROVE Inflammation Interaction manuscript mechanism medication Metabolic diseases molecular NET NETs neutrophil Neutrophils Occurrence organs pathogenesis of COVID-19 Pathogens patients protease protein S reaction recruitment Regulatory Research Respiratory failure SARS-CoV-1 SARS-CoV-2 serine 2 Significance Spread Stress the SARS-CoV-2 therapeutic strategy therapy thromboembolic complication tissue TMPRSS2 Treatment
[DOI] 10.3390/cells10010151 PMC 바로가기 [Article Type] Review

Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma

Research

Published on 2021-01-072022-10-28
Journal: Respiratory Research [Category] COVID-19,

[키워드] ACE2 angiotensin Asthma biopsies biopsy Blood body mass index clinical parameter Clusters Cohort Corticosteroid COVID-19 disease enzyme European examined expressed expression expression level functions furin FURIN gene Gender Gene Expression greater host cells inflammasome activation Inflammation inflammatory cells Invasion Level lung male Microarray molecular molecular phenotype morbidity and mortality mRNA expression multivariate analyses neutrophil neutrophilic Neutrophils outcome oxidative phosphorylation Phenotypes protease Proteases Result risk SARS-COV-2 infection serine 2 Severe asthma severity significantly significantly higher significantly increased sputum TMPRSS2 TMPRSS2 level transmembrane Type
[DOI] 10.1186/s12931-020-01605-8 PMC 바로가기 [Article Type] Research

Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2

530

Published on 2021-01-052022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19,

[키워드] ACE2 acute respiratory syndrome affected age androgen Androgen receptor androgen signaling angiotensin-converting enzyme 2 antagonist approved BET BET inhibitors Cell cells characterized clinical development Cohort coronavirus COVID-19 COVID-19 pandemic Critical domain effective elevated epidemiological expression Factor female greater Host host protein in vitro indication inhibited inhibitor Lung epithelial cells male morbidity Mortality New Prevent prevention of COVID-19 Prostate Prostate cancer protease Protective Protein receptor regulate replicate responsible Result SARS-CoV-2 SARS-CoV-2 entry factor SARS-COV-2 infection serine 2 Sex hormones Significance smoking subset suggested Support Supporting targeting therapeutic target TMPRSS2 transcriptional transcriptional regulation transmembrane Treatment viable treatment virus
[DOI] 10.1073/pnas.2021450118 PMC 바로가기 [Article Type] 530

Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study

COVID-19의 입원과 관련된 인지 장애: 관찰 코호트 연구의 결과

Observational Study

Published on 2021-01-012022-09-11
Journal: Brain, behavior, and immunity [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, 임상,

[키워드] 95% CI ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alzheimer's disease amnestic angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 association Biomarkers Blood Care clinical condition cognitive Cognitive disorder cognitive disorders coronavirus COVID-19 COVID-19 test COVID‐19 deficiency delirium Dementia direct association disease disorder enzyme European Evidence examined Factors genetic background Genetic variant genetic variants Genetic variations highlighting Hospital admission Hospitalization immune immune deficiency implication include Infection medical condition Observational cohort study pandemic participant Patient Phenotypes positive Pre-existing conditions Prostate cancer protease Protective respiratory Result risk factor Risk factors SARS-CoV-2 Serine serine 2 severe acute respiratory syndrome Coronavirus tested TMPRSS2 transmembrane transmembrane protease serine 2 UK biobank was obtained with COVID-19
[DOI] 10.1016/j.bbi.2020.10.019 PMC 바로가기 [Article Type] Observational Study

Strong Correlation between the Case Fatality Rate of COVID-19 and the rs6598045 Single Nucleotide Polymorphism (SNP) of the Interferon-Induced Transmembrane Protein 3 ( IFITM3 ) Gene at the Population-Level

인구 수준에서 코로나19의 치사율과 인터페론 유도 막관통 단백질 3(IFITM3) 유전자의 rs6598045 단일 뉴클레오티드 다형성(SNP) 사이의 강한 상관관계

Brief Report

Published on 2020-12-302022-09-10
Journal: Genes [Category] MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] 1000 Genomes Project ABO ABO gene ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition allele allele frequency angiotensin angiotensin I best Biomarker calculated Case fatality rate case fatality rates caused coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 case COVID-19 cases death distribution enzyme ethnic group Ethnic groups evaluated Fatality rate Genes Genetic Genetic polymorphism genetic polymorphisms Health Organization identify IFITM3 IL6 Infection interferon Interferon-induced transmembrane protein 3 interleukin 6 knowledge leucine LZTFL1 mechanism nucleotide pandemic disease Pathogenesis pathogenesis of COVID-19 performed polymorphism Polymorphisms protease Protein protein 3 Rate regression analysis reported respiratory risk SARS-CoV-2 SAS version 9.4 Serine serine 2 severe acute respiratory syndrome Coronavirus single nucleotide Single nucleotide polymorphism SNP Strong TMPRSS2 Transcription transmembrane transmembrane protein WHO World Health Organization
[DOI] 10.3390/genes12010042 PMC 바로가기 [Article Type] Brief Report

Structural Variability, Expression Profile, and Pharmacogenetic Properties of TMPRSS2 Gene as a Potential Target for COVID-19 Therapy

COVID-19 치료의 잠재적 표적인 TMPRSS2 유전자의 구조적 다양성, 발현 프로필 및 약리학적 특성

Article

Published on 2020-12-252022-09-10
Journal: Genes [Category] MERS, SARS, 변종, 치료기술, 치료제,

[키워드] ACE2 acetaminophen acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alveolar cell alveolar cells Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Asian Basigin BSG co-expressed copy number copy number variant coronavirus COVID-19 COVID-19 therapy Curcumin distribution downregulate drug enzyme European populations ExoN expression expression levels frequencies Frequency genome-wide data human cells human population human populations Interaction interactions involved lung microRNA MicroRNAs Missense mutation Paracetamol pharmacotranscriptomics Polymorphisms Population Potential predicted priming profile profiles property Prostate cancer Protein ranged receptor regulate Regulation respiratory respiratory tract cells SARS-CoV-2 SARS-CoV-2 cell Serine serine 2 serine protease severe acute respiratory syndrome Coronavirus significantly higher Single-cell RNA sequencing single-nucleotide Single-nucleotide polymorphisms SNV target therapy tissue-specific expression TMPRSS2 Variability
[DOI] 10.3390/genes12010019 PMC 바로가기 [Article Type] Article

Impact of COVID-19 on the thyroid gland: an update

Article

Published on 2020-11-252022-10-28
Journal: Reviews in Endocrine & Metabolic Disorders [Category] COVID-19, SARS,

SARS-CoV-2, Early Entry Events

Review Article

Published on 2020-11-242022-10-30
Journal: Journal of Pathogens [Category] COVID-19,