Effect modification of the association between comorbidities and severe course of COVID-19 disease by age of study participants: a systematic review and meta-analysisSystematic Review Update Published on 2021-06-302022-10-28 Journal: Systematic Reviews [Category] COVID-19, MERS, SARS, [키워드] 95% CI Admission age association behavioural calculated Comorbidities Comorbidity Comprehensive conditions Course COVID-19 COVID-19 cases COVID-19 disease COVID-19 hospitalisation COVID-19-associated hospitalisation COVID-19-associated mortality death decrease demographics disease Diseases Effect Effect modification estimate estimates Evidence explained Factor Health heterogeneity high risk hospitalisation hypertension ICU ICU admission individual intensive care Interaction International Intervention less magnitude median age meta-analyses Meta-analysis meta-regression Modification National NPI performed quantitative synthesis recommendation renal reported required Result risk risk factor robust severe COVID-19 Severity of disease significantly Study participants study population supplementary material systematic review target Vaccination strategies Vaccination strategy [DOI] 10.1186/s13643-021-01732-3 PMC 바로가기 [Article Type] Systematic Review Update
A sensitive indicator for the severity of COVID-19: thiolCOVID-19의 심각성에 대한 민감한 지표: 티올Article Published on 2021-06-282022-09-10 Journal: Turkish Journal of Medical Sciences [Category] MERS, SARS, 바이오마커, [키워드] 95%CI Biomarker cellular cellular signaling pathways Concentration controls COVID-19 Critical Decline Depleted disease severity enrolled exhibited group healthy controls highest highlight immune response independent risk factor Infection Inflammation Logistic regression analyses Logistic regression analysis material Mild moderate outcome Patient patients with SARS-CoV-2 progression Result SARS-COV-2 infection sensitive indicator sensitivity severe group severity severity of COVID-19 Severity of disease Severity of infection significantly specificity subject the disease thiol vital role vital roles [DOI] 10.3906/sag-2011-139 PMC 바로가기 [Article Type] Article
Could serum albumin value and thrombocyte/lymphocyte ratio be an important prognostic factor in determining the severity of COVID 19?혈청 알부민 값과 혈소판/림프구 비율이 COVID 19의 중증도를 결정하는 중요한 예후 인자가 될 수 있습니까?Article Published on 2021-06-282022-09-10 Journal: Turkish Journal of Medical Sciences [Category] MERS, SARS, 바이오마커, [키워드] Admission age albumin an area area of interest clinical marker clinical markers Comorbidity COVID demographic demographic data evaluate Follow-up groups highest hospital Hospitalization ICU intensive care lymphocyte Lymphocyte count material Older Patient patients with COVID-19 platelet lenfosit ratio Prognostic factor Result risk Risk assessment serum albumin serum albumin value severity Severity of COVID 19 Severity of disease Sex statistically significant difference the disease thrombocyte two group two groups were recorded [DOI] 10.3906/sag-2008-285 PMC 바로가기 [Article Type] Article
Long-Term Longitudinal Evaluation of Six Commercial Immunoassays for the Detection of IgM and IgG Antibodies against SARS CoV-2SARS COV-2에 대한 IgM 및 IgG 항체의 검출에 대한 6 개의 상업적 면역 분석의 장기 종단 평가Multicenter Study Published on 2021-06-262022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] Analysis antibody antibody levels Antigen assays best Characteristics Chemiluminescent assay chemiluminescent immunoassay CLIA clinical form CMIA concern COVID-19 data interpretation detection disease severity ECLIA ELISA evaluated Follow-up visit follow-up visits healthy humoral Humoral response IgG IgM IgM and IgG immunoassay Increases independent longitudinal Microparticle moderate Patient performed positive post-symptom onset PSO raised remained required sample selection SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection sensitivity Seroconversion Serological assay serological assays serology Seropositivity serum sample serum samples severity Severity of disease significantly specificity the disease were used [DOI] 10.3390/v13071244 PMC 바로가기 [Article Type] Multicenter Study
PNPLA3 and TLL-1 Polymorphisms as Potential Predictors of Disease Severity in Patients With COVID-19Cell and Developmental Biology Published on 2021-06-232022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] 95% CI absence ACE2 Admission Affect angiotensin-converting enzyme 2 binding characterized cleavage site Clinical course Comorbidity consecutive patient contribute Course COVID-19 death determinant disease course early phase Genetic polymorphism Genetic variant Genotype higher risk host cell host gene host receptor host’s cells IFNL3 immune stimulation in silico increased risk infect Infection Inflammation Intensive involved MERTK Mild nasopharyngeal swabs NLRP3 inflammasome nucleic acid older patient outcome pandemic Pathogenesis pathogenesis of COVID-19 pathway Patient PNPLA3 PNPLA3 I148M polymorphism Potential predicted Predictive Prognosis protease Protease activity Protein protein cleavage re-infect Reinfection risk SARS-CoV-2 SARS-COV-2 infection Severity of disease Sex significantly Specific spike subject subsequent Support the SARS-CoV-2 the Spike therapeutic approaches therapy tissue damage TLL-1 upregulation variant were assessed younger patient [DOI] 10.3389/fcell.2021.627914 PMC 바로가기 [Article Type] Cell and Developmental Biology
A Comparative Analysis of Coronavirus Nucleocapsid (N) Proteins Reveals the SADS-CoV N Protein Antagonizes IFN-β Production by Inducing Ubiquitination of RIG-IImmunology Published on 2021-06-162022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute diarrhea acute respiratory syndrome Analysis binding activity caused claimed Comparative conducted coronavirus CoV CoV infection COVID-19 pandemic CoVs Degradation Delay epidemic diarrhea Host IBV IFN IFN response IFN-β independent Inducing infected cell Infectious Bronchitis Virus inhibiting Interaction interferon MERS-CoV Middle East nucleocapsid nucleocapsid protein offer Porcine deltacoronavirus Production Protein retinoic acid-inducible gene I (RIG-I) RIG-I RNA SARS-CoV SARS-CoV-2 Severity of disease subsequent suppress swine acute diarrhea syndrome coronavirus (SADS-CoV) syndrome the N protein therapy ubiquitination Viral protein viruses [DOI] 10.3389/fimmu.2021.688758 PMC 바로가기 [Article Type] Immunology
COVID‐19 in a country with a very high prevalence of diabetes: The impact of admission hyperglycaemia on mortalityOriginal Research Article Published on 2021-06-142022-10-31 Journal: Endocrinology, Diabetes & Metabolism [Category] COVID-19, MERS, [키워드] 95%CI Admission association biochemical Characteristics characteristics of patient clinical country COVID‐19 COVID‐19 patients COVID‐19 D‐dimer determinate diabete diabetes Early detection evaluate evaluated Frequency Glucose had more hyperglycaemia IMV Invasive mechanical ventilation Lymphocyte count male Metabolic diseases Mortality NLR Pandemics Patient patients Prevalence Regional Result risk factor risk of death severity Severity of disease Treatment Trial urea was performed [DOI] 10.1002/edm2.279 PMC 바로가기 [Article Type] Original Research Article
A multi-method approach to modeling COVID-19 disease dynamics in the United StatesArticle Published on 2021-06-142022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] Analysis approach calibrated can be used composed Computational models COVID-19 COVID-19 disease cumulative deaths demonstrated granular hospitalizations ICU Infection Laboratory methodology Metrics Model outcome outlined parameter public health risk Severity of disease Spread the United State Threats used to evaluate viral infection [DOI] 10.1038/s41598-021-92000-w PMC 바로가기 [Article Type] Article
Sex-Related Overactivation of NLRP3 Inflammasome Increases Lethality of the Male COVID-19 PatientsMolecular Biosciences Published on 2021-06-042022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Activation Affect Asymptomatic caused COVID-19 COVID-19 pandemic COVID-19 symptoms Critical Cytokine storm excessive inflammation heterogeneity high mortality identify increase infected with SARS-CoV-2 lethality male mechanism NLRP3 NLRP3 inflammasome overactivation P2X7R Patient potential mechanism potential therapeutic targets Probability reported SARS-CoV-2 SARS-COV-2 infection severe cases severe symptom severity Severity of disease Sex Significant [DOI] 10.3389/fmolb.2021.671363 PMC 바로가기 [Article Type] Molecular Biosciences
Biomarkers and outcomes of COVID-19 hospitalisations: systematic review and meta-analysisCOVID-19 입원의 바이오마커 및 결과: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-06-012022-08-31 Journal: BMJ evidence-based medicine [Category] MERS, SARS, 바이오마커, [키워드] 2019-nCoV 95% CI Admission Alanine alanine aminotransferase ALT aspartate Aspartate aminotransferase association AST Biomarker Biomarkers C reactive protein clinical decision Composite Consensus coronavirus COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity creatine creatine kinase creatinine Critical Critical care CRP D-dimer Decision making Diseases elevated English evaluate evidence-based practice forest plot forest plots global health healthcare heterogeneity high-risk patient High-risk patients higher risk hospitalised patient Hospitalised patients IMPROVE In-hospital include independent Infectious disease infectious disease medicine Infectious diseases intensive care intensive care unit admission Invasive mechanical ventilation Laboratory laboratory findings Lactate lactate dehydrogenase LDH lymphocyte lymphopenia management medical subject heading Medical Subject Headings meta-analyses Meta-analysis MOOSE Mortality nCoV observational studies observational study outcome outcomes oxygen oxygen saturation pandemic PCT Platelets procalcitonin Prognosis Publication bia publication bias Random-effects models resource resources SARS-CoV-2 selected sensitivity analysis severe disease Severity of disease systematic review thrombocytopenia Web of Science were assessed [DOI] 10.1136/bmjebm-2020-111536 PMC 바로가기 [Article Type] Meta-Analysis