Evidence that regulation of intramembrane proteolysis is mediated by substrate gating during sporulation in Bacillus subtilis막내 단백질 분해의 조절이 Bacillus subtilis에서 포자 형성 동안 기질 게이팅에 의해 매개된다는 증거Research Article Published on 2018-11-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation active form association Bacillus subtilis catalytic center catalyzed CBS Cell cells cleavage cleave cleaving co-immunoprecipitation conformation conformational change conserved Critical cystathionine cytoplasmic daughter cells domain enzyme Evidence Extracellular family member fluorescence microscopy forespore Gene Expression homolog immunoprecipitation in vivo inactive information Interaction interaction site interior late stage mechanism membrane membrane protein Methanocaldococcus Morphological mother mother cell open pathway Pathways protease proteolysis proteolytic activation Regulation remained secreted Signal transduction Signaling signaling pathway Space sporulation Support transcription factor transducing Trigger triggers [DOI] 10.1371/journal.pgen.1007753 PMC 바로가기 [Article Type] Research Article
ISP1-Anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding MotilityArticle Published on 2018-09-102024-08-28 Journal: Current Biology [Category] 말라리아, [키워드] cGMP guanylate cyclase malaria Mosquito motility Ookinete Plasmodium Signal transduction
Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose마이코박테리아의 세포 외피 스트레스는 트레할로스에 대한 반응으로 새로운 신호 전달 ATPase IniR에 의해 조절됩니다Research Article Published on 2017-12-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation activator Affect assembly ATPase Author BAC bacterial cell biogenesis cascade Cell cell envelope cell wall complex compounds damaged defect domain domains drug ethambutol experiment explain exposure to family Gram-negative bacteria homologue identify include induce inducer integrity involved isoniazid latter gene Lipid lipids locus mechanism Mutagenesis mutant mutants mutations mycobacteria mycobacterial Mycobacterium operon overexpression pathway promoter PROTECT regulated Regulation regulator Regulatory regulatory gene respond RNAseq shown signal Signal transduction Signaling Stress stress response sugar sugars the cell transcriptional regulator transposon trehalose Tuberculosis understanding unique [DOI] 10.1371/journal.pgen.1007131 PMC 바로가기 [Article Type] Research Article
The MEK Inhibitors Trametinib and Cobimetinib Induce a Type I Interferon Response in Human KeratinocytesArticle Published on 2017-10-242023-08-30 Journal: International Journal of Molecular Sciences [Category] E형 간염, [키워드] chemokine Dabrafenib interferon κ Signal transduction Vemurafenib [DOI] 10.3390/ijms18102227 PMC 바로가기 [Article Type] Article
Molecular cloning of chicken interleukin-17B, which induces proinflammatory cytokines through activation of the NF-κB signaling pathwayarticle Published on 2017-09-302024-09-01 Journal: Developmental & Comparative Immunology [Category] 살모넬라증, [키워드] chicken cytokine IL-17B NF-κB Signal transduction [Article Type] article
CRAMP deficiency leads to a pro-inflammatory phenotype and impaired phagocytosis after exposure to bacterial meningitis pathogensCRAMP 결핍은 세균성 수막염 병원체에 노출된 후 염증 유발 표현형과 손상된 식세포작용을 초래합니다.Research Published on 2017-09-162024-08-01 Journal: Cell Communication and Signaling : CCS [Category] 폐렴구균 감염증, [키워드] antimicrobial peptide Cathelicidin Cramp glial cell Innate immunity Signal transduction [DOI] 10.1186/s12964-017-0190-1 PMC 바로가기 [Article Type] Research
Small Molecules to the Rescue: Inhibition of Cytokine Signaling in Immune-mediated DiseasesArticle Published on 2017-07-132024-09-04 Journal: Journal of autoimmunity [Category] 대상포진, [키워드] Autoimmunity Cytokines Drug development Inflammation Signal transduction therapy [DOI] 10.1016/j.jaut.2017.06.006 PMC 바로가기 [Article Type] Article
Perception of root‐active CLE peptides requires CORYNE function in the phloem vasculatureArticle Published on 2017-06-122023-08-30 Journal: EMBO Reports [Category] E형 간염, [키워드] CLAVATA CLE45 MAKR5 SERK Development & Differentiation Plant Biology receptor kinase Signal transduction [DOI] 10.15252/embr.201643535 PMC 바로가기 [Article Type] Article
An Overview of Two-Component Signal Transduction Systems Implicated in Extra-Intestinal Pathogenic E. coli InfectionsReview Published on 2017-05-092023-05-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] Fulltext, 조류인플루엔자, [키워드] APEC ExPEC MAEC/NMEC Signal transduction two-component systems UPEC virulence factors [DOI] 10.3389/fcimb.2017.00162 PMC 바로가기 [Article Type] Review
Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans인간 진균 병원체 크립토코커스 네오포르만스에서 칼시뉴린-Crz1 스트레스 반응 전사 네트워크의 해명Research Article Published on 2017-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated appear ascomycete ascomycetes Aspergillus fumigatus binding calcineurin calcium calmodulin Candida albican Candida albicans cascade Cell cell wall cellular cna1 conserved contribute Control Cryptococcus neoforman Cryptococcus neoformans docking domain down-regulated downstream Evidence expression of gene Factor function functions fungal fungal pathogen fungal pathogens fungi high temperature involved majority motif mRNA mRNA expression mutant mutants nuclear translocation nucleus P-bodies P-body pathogen pathogenic Pathogens pathway phenotype Phenotypes pheromone phosphatase post-transcriptional levels predicted promote promoter promoter region promoter regions Protein regulate regulated regulatory network responses RNA-sequencing Saccharomyces cerevisiae Serine Signal transduction Signaling small molecule Stress stress granule stress granules stress response survival target target gene Target genes targets threonine Transcription transcription factor transcriptional Transport virulence wild-type [DOI] 10.1371/journal.pgen.1006667 PMC 바로가기 [Article Type] Research Article