A high-affinity RBD-targeting nanobody improves fusion partner’s potency against SARS-CoV-2
고친화성 RBD 표적 나노바디는 SARS-CoV-2에 대한 융합 파트너의 효능을 향상시킵니다
Research Article
[키워드] ACE2
ACE2-RBD binding
addition
Affinity maturation
antibodies
antibody
attachment
bind
binding affinity
Characteristics
competitive binding
conserved
Crystallographic studies
Crystallographic study
displaying
distal
domain
Effect
effective
effective strategy
epitope
epitope distal
Epitopes
fusing
fusion strategy
generate
high-affinity synthetic nanobody
host cells
host receptor
hotspot
identify
immunological
IMPROVE
in vitro
increase
infect
Infection
interface
kDa
library screening
llama-derived single-chain nanobodies
nanobodies
nanobody
nanomolar affinity
neutralization activity
Neutralizing
Neutralizing activity
Neutralizing antibodies
offer
potency
probe
Protein
provide
pseudovirus
RBD
RBD binding
RBD-targeting nanobodies
RBD-targeting nanobody
RBM
RBM-antibodies
RBM-binders
Receptor-binding domain
receptor-binding motif
recognize
recognizing
Research
S RBD
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 pseudovirus
simple
simplicity
single-chain antibody
speed
spike
Spike protein
spike receptor-binding domain
SR31
structure-based design
sybody
target
the receptor-binding domain
the SARS-CoV-2
therapeutic
tool protein
toolkit
two modestly neutralizing sybodies
[DOI] 10.1371/journal.ppat.1009328 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1009328 PMC 바로가기 [Article Type] Research Article