Porcine Epidemic Diarrhea Virus Envelope Protein Blocks SLA-DR Expression in Barrow-Derived Dendritic Cells by Inhibiting Promoters ActivationImmunology Published on 2021-11-102022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] Activation adaptive immune response 3 addition Alter Antigen Antigen presentation antigen-presenting cell APCS block blocked caused CD4 Cell contagious DCs Degradation dendritic cell disease envelope envelope protein epidemic diarrhea expression had no in vitro model in vivo indicated Infection inhibited inhibitor interactions intestinal intestinal epithelial cells involved leukocyte MG132 MHC-II MHC-II molecule not affect participated pathogenic mechanism pathway PEDV PEDV-envelope protein Porcine epidemic diarrhea virus promoters Protein protein level protein levels replicated Replication reporter SLA-DR structural protein Subunit vaccine T cell activation target transcriptional transcriptional level transfected cell Treatment virus [DOI] 10.3389/fimmu.2021.741425 PMC 바로가기 [Article Type] Immunology
Peritoneal Administration of a Subunit Vaccine Encapsulated in a Nanodelivery System Not Only Augments Systemic Responses against SARS-CoV-2 but Also Stimulates Responses in the Respiratory Tract나노 전달 시스템에 캡슐화 된 서브 유닛 백신의 복막 투여 SARS-COV-2에 대한 체계적인 반응을 강화 할뿐만 아니라 호흡기에서의 반응을 자극합니다.Article Published on 2021-11-022022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] activated addition adjuvant delivery particles administration Antibody Response Bronchoalveolar lavage chitosan circulating COVID-19 pandemic COVID-19 vaccine demonstrated disease elicited global health Health herd immunity IgA IgG immune responses Immunity immunization immunized mice immunogenicity investigated lung homogenate lung homogenates mass vaccination mice mucosal mucosal immunity neutralizing capacity Particle peritoneal immunization receiving respiratory respiratory tract response SARS-CoV-2 SARS-CoV-2 spike glycoprotein SARS-CoV-2-infected patients SARS-CoV-2-specific IgG SARS-CoV-2-specific immune response SARS-CoV-2-specific immune responses spike glycoprotein spike-specific T cell Spread stimulate stimulated subunit Subunit vaccine System systemic T cell tract vaccination vaccine candidate [DOI] 10.3390/v13112202 PMC 바로가기 [Article Type] Article
A Modular Biomaterial Scaffold-Based Vaccine Elicits Durable Adaptive Immunity to Subunit SARS-CoV-2 Antigens모듈식 생체 재료 스캐폴드 기반 백신은 소단위 SARS-CoV-2 항원에 대한 내구성 있는 적응 면역을 유도합니다Article Published on 2021-11-012022-09-11 Journal: Advanced Healthcare Materials [Category] MERS, SARS, 변종, 진단, [키워드] activate adaptive Adaptive immunity antibodies antibody Antigen antigen-presenting cell antigen-presenting cells APCS biomaterial cellular colony-stimulating factor coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 vaccine cytotoxic cytotoxic T-cells described facilitate generate GM-CSF granulocyte granulocyte-macrophage colony-stimulating factor Humoral response immune responses Immunity in vitro injection lack mesoporous silica rods Monophosphoryl lipid A monophosphoryl lipid A (MPLA) MPLA pandemic Pathogens persistent platform poorly immunogenic Protein protein antigen RBD Receptor binding domain recombinant proteins recruit regimen robust rod Safe SARS-CoV-2 SARS-CoV-2 antigens SARS-CoV-2 variant SARS-CoV-2 viral silica Subunit vaccine subunit vaccines T-cells tested Toll-like receptor toll-like receptor 4 Vaccine vaccine platform Vaccines Viral viral neutralization [DOI] 10.1002/adhm.202101370 PMC 바로가기 [Article Type] Article
Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant고분자 글리코 보조제에 대한 접합을 통한 SARS-CoV-2 항원에 대한 강력한 세포 및 체액 면역 생성Article Published on 2021-11-012022-09-12 Journal: Biomaterials [Category] MERS, SARS, 진단, [키워드] activate activated adjuvant adjuvants amplified antibody Antigen antigen-presenting cell antigen-specific antibody APCS B cells caused CD4 CD8 cells cellular composed convalescent human serum COVID-19 COVID-19 vaccine Disease model effective elicit follicular generate Generation Glycopolymers Humoral immunity Humoral response IgGs immune response increase in long-lasting mice monomer Neutralizing Neutralizing titer platform Polymer-protein conjugates Polymeric glyco-adjuvant producing Protein protein antigen receptor robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 virus secreting shown Spread subunit Subunit vaccine Subunit vaccine formulation. T cell responses T cells the Spike the vaccine TLR7 Toll-like receptor triggering vaccination Vaccine vaccine candidate wild-type yielding [DOI] 10.1016/j.biomaterials.2021.121159 PMC 바로가기 [Article Type] Article
An Established Th2-Oriented Response to an Alum-Adjuvanted SARS-CoV-2 Subunit Vaccine Is Not Reversible by Sequential Immunization with Nucleic Acid-Adjuvanted Th1-Oriented Subunit VaccinesArticle Published on 2021-11-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] absence acute respiratory syndrome Administered alum adjuvant boost cellular immunity changed coronavirus coronavirus disease COVID-19 CpG demonstrated dose Efficacy eosinophil form Heterologous heterologous boost immunization homogenous boost immunization inactivated induce mice mRNA vaccine nucleic acid adjuvant overcome Pneumonia Prime-boost pulmonary immunopathology question reported response reversed Reversible SARS-CoV-2 SARS-CoV-2 subunit vaccine SARS-CoV-2 vaccine SARS-CoV-2 vaccines subunit Subunit vaccine subunit vaccines Th1 Th1/Th2 orientation Th2 Th2 response Vaccine Vaccines were used [DOI] 10.3390/vaccines9111261 PMC 바로가기 [Article Type] Article
Development of an IgG-Fc fusion COVID-19 subunit vaccine, AKS-452IgG-Fc 융합 코로나19 서브유닛 백신 AKS-452 개발Article Published on 2021-10-292022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 진단, [키워드] adjuvant adjuvants African Antigen APCS augmentation B.1.351 Cell cells clinical development Clinical studies clinical study clinical symptom Clinical symptoms comparable coronavirus COVID-19 COVID-19 pandemic development dose doses ENhance evaluated expectation Fc-fusion FcγR fusion protein greater huACE2 human IgG1 Fc IgG titers immunogenic immunogenicity Infection Infectious disease K18 live SARS-CoV-2 maintain mice Neonatal neutralization neutralizing IgG titer Neutralizing titer NHP NHPs non-human primate non-human primates pandemic phase preclinical studies preclinical study Prophylaxis receptor Receptor binding domain Region SARS-CoV-2 viral infection SARS-CoV-2 virus single dose South Spike protein subunit Subunit vaccine Support the SARS-CoV-2 USA-WA1/2020 Vaccine Vero-E6 cells Viral viral infection viral spike protein viral strain viral variant virus virus infection [DOI] 10.1016/j.vaccine.2021.09.077 PMC 바로가기 [Article Type] Article
Immunodominant linear B cell epitopes in the spike and membrane proteins of SARS-CoV-2 identified by immunoinformatics prediction and immunoassay면역정보학 예측 및 면역분석으로 확인된 SARS-CoV-2의 스파이크 및 막 단백질의 면역우성 선형 B 세포 에피토프Article Published on 2021-10-142022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] Amino acid amino acid change amino acid changes Analysis B cell B cell epitope B cell epitopes C-terminus Computational biology and bioinformatics convalescent sera COVID-19 infected patients death decrease Efficacy ELISA ENhance epitope epitope mapping Epitopes greater highlighting immunoassay immunodominant immunodominant epitopes immunoinformatics immunology IMPROVE increase in infect infected patients linear linear B M protein membrane membrane protein Microbiology NTD number of deaths predicted Protein provide RBD Region resulting S1/S2 cleavage site S2 domain SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike receptor-binding domain SARS-CoV-2 vaccine sera spike receptor-binding domain subunit Subunit vaccine the SARS-CoV-2 Vaccine Vaccine design vaccine efficacy variants variants of concern Viral [DOI] 10.1038/s41598-021-99642-w PMC 바로가기 [Article Type] Article
Hydrogel‐Based Slow Release of a Receptor‐Binding Domain Subunit Vaccine Elicits Neutralizing Antibody Responses Against SARS‐CoV‐2Research Article Published on 2021-10-142022-10-28 Journal: Advanced Materials (Deerfield Beach, Fla.) [Category] COVID-19, MERS, SARS, [키워드] adjuvant adjuvants administration Against alum Antigen clinically complex COVID‐19 COVID‐19 effective vaccine elicit elicited ENhance Health host cell Humoral immunity hydrogels immunization Impact increase induce lentivirus mitigate neutralization Neutralization assay Neutralizing Neutralizing antibodies neutralizing response Pandemics PNP poorly immunogenic provide RBD receptor‐binding domain Release response robust SARS‐CoV‐2 SARS‐CoV‐2 virus SARS‐CoV‐2 shown significantly slow Spike protein spike variants subunit Subunit vaccine subunit vaccines sustained Vaccine variants of concern virus while [DOI] 10.1002/adma.202104362 PMC 바로가기 [Article Type] Research Article
The Hepatitis E Virus Open Reading Frame 2 Protein: Beyond Viral CapsidReview Published on 2021-10-072023-08-30 Journal: Frontiers in Microbiology [Category] E형 간염, [키워드] capsids hepatitis E virus HEV-ORF2 protein Innate immunity Quasi-enveloped virion Subunit vaccine [DOI] 10.3389/fmicb.2021.739124 PMC 바로가기 [Article Type] Review
Development of a Recombinant RBD Subunit Vaccine for SARS-CoV-2Article Published on 2021-09-262022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Cellular immune response COVID-19 development Emergency use Fc fragment fused fusion protein human IgG1 humoral IFN-γ IgG IL-10 IL-2 immunized mice induce mice monomer neutralizing antibody neutralizing epitopes Novel coronavirus pandemic Pneumonia Protein RBD RBD-Fc RBD-Fc fusion protein Receptor binding domain recombinant SARS-CoV-2 secretion significantly splenocyte subunit Subunit vaccine the S protein Vaccine vaccine candidate widespread [DOI] 10.3390/v13101936 PMC 바로가기 [Article Type] Article