Prominence of urinary biomarkers for bladder cancer in the COVID-19 era: From the commercially available to new prospective candidates코로나19 시대 방광암에 대한 요도 바이오마커의 중요성: 상용화부터 신규 후보까지Review Published on 2021-09-012022-09-11 Journal: Investigative and clinical urology [Category] 바이오마커, 치료제, [키워드] Biomarker Biomarkers Bladder cancer candidate clinical care COVID-19 detection disease DNA Evolution highlight identify IMPROVE in urine management marker Molecular marker molecular markers Neoplasms outcomes overcome Patient prominence Protein Research risk RNA Stratification targeted therapy Tumor tumor markers Urinary bladder Urinary bladder neoplasms. Urine [DOI] 10.4111/icu.20210194 PMC 바로가기 [Article Type] Review
Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions생체 내 SARS-CoV-2 상호 작용의 포괄적 인 매핑은 기능적 바이러스-숙주 상호 작용을 나타냅니다Article Published on 2021-08-252022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] approach bind Cell cells cellular Comprehensive element epigenomics functional Genome global health Health Host host mRNA identify Illumina in viral in vivo Interaction interactions Methylation mitochondrial molecular mutant observé pathogenicity platform regions report reveal RNA RNA sequencing RNA-RNA interaction RNA-RNA interactions RNAs SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 viral secondary structure Sequencing small nucleolar RNA structures subgenomic RNA subgenomic RNAs targeted therapy the SARS-CoV-2 genome untranslated regions Viral viral genome virus virus genome virus infection Virus-host interaction Virus-host interactions wildtype Δ382 [DOI] 10.1038/s41467-021-25357-1 PMC 바로가기 [Article Type] Article
Immune System Disequilibrium—Neutrophils, Their Extracellular Traps, and COVID-19-Induced SepsisMedicine Published on 2021-08-182022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome adaptive Apoptosis cell death Complete component coronavirus coronavirus disease COVID-19 COVID-19 phenotypes described determine dysregulation equilibrium extracellular traps Host immune cells immune system Innate innate immune system NETosis neutrophil Neutrophil extracellular trap organ dysfunction organ injury pandemic pathogen pathophysiological potential therapeutic target responsible SARS-CoV-2 STEM System targeted therapy [DOI] 10.3389/fmed.2021.711397 PMC 바로가기 [Article Type] Medicine
Co-infections observed in SARS-CoV-2 positive patients using a rapid diagnostic test빠른 진단 테스트를 사용하여 SARS-COV-2 양성 환자에서 관찰 된 공동 감염Article Published on 2021-08-112022-09-01 Journal: Scientific Reports [Category] MERS, 진단, 치료기술, 치료제, [키워드] acute respiratory symptoms age Antibiotic resistance Antibiotic therapy Antibiotics antimicrobial resistance average average age Bacteria BAL bioMérieux Bronchoalveolar lavage clinical microbiology Coinfection consecutive patient consecutive patients COVID COVID-19 patients Culture cultures defined detect diagnostic test diagnostic tests evidence of examined female followed by France Genetic H. influenzae hospital information isolate male management marker microbial modulate Molecular medicine MOST obtaining information P. aeruginosa Panel pathogen Pathogens Patient Patient care performed phenomenon Pneumonia pneumoniae positive positive sample potential limitation potential limitations Predictive Rapid Rapid diagnostic test respiratory Respiratory failure respiratory infections respiratory sample Respiratory samples SARS-CoV-2 positive patient sputum targeted therapy Treatment virus viruses [DOI] 10.1038/s41598-021-95772-3 PMC 바로가기 [Article Type] Article
Emerging Importance of Chemokine Receptor CXCR4 and Its Ligand in Liver DiseaseReview Published on 2021-07-272023-08-30 Journal: Frontiers in Cell and Developmental Biology [Category] E형 간염, [키워드] CXCL12 CXCR4 Liver disease liver specific cells stem cells targeted therapy [DOI] 10.3389/fcell.2021.716842 PMC 바로가기 [Article Type] Review
N6-methyladenosine methyltransferases: functions, regulation, and clinical potentialReview Published on 2021-07-272022-10-29 Journal: Journal of Hematology & Oncology [Category] COVID-19, [키워드] Affect approach Cancer Chemotherapy complexes Drug discovery function functions highlight Immunotherapy m6A m6A methyltransferase methyltransferase Modification N6-methyladenosine Noncoding RNAs pathway Proteins Radiotherapy Regulation reported RNA RNAs stability targeted therapy therapy Therapy resistance Transcriptome translation widespread [DOI] 10.1186/s13045-021-01129-8 PMC 바로가기 [Article Type] Review
Proteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis폐 섬유증 환자의 COVID-19 합병증의 단백질 학 및 대사제 분석Article Published on 2021-07-162022-09-10 Journal: Scientific Reports [Category] 바이오마커, 유전자 메커니즘, 치료기술, 치료제, [키워드] acquisition Analysis analyzed association Cell Biology Clustering collected Complication differential expression disease enrichment analysis Evidence FcγR feature fibrosis FIVE independent inflammatory pathways lesion lesions lobes lower lobe lower lobes Mechanisms of disease medical record medical records metabolites metabolomics Molecular medicine Pathogenesis pathway Pathways Patient phagocytosis PPAR signaling progression Protein proteomics pulmonary pulmonary fibrosis quantification serum biomarker serum biomarkers signaling pathway signaling pathways targeted therapy urea urea cycle were used [DOI] 10.1038/s41598-021-94256-8 PMC 바로가기 [Article Type] Article
Pharmacokinetic interactions between the potential COVID-19 treatment drugs lopinavir/ritonavir and arbidol in ratsArticle Published on 2021-07-152022-10-04 Journal: Journal of Zhejiang University. Science. B [Category] SARS, 신약개발, [키워드] acute respiratory syndrome antiviral drug Antiviral effect approved caused China Chloroquine clinical trials combination therapy confirmed case coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients drug Efficacy exceeded Favipiravir hospital Hydroxychloroquine in some Interaction pandemic regimen Remdesivir reported retrospective cohort study SARS-CoV-2 shown targeted therapy Treatment [DOI] 10.1631/jzus.B2000728 PMC 바로가기 [Article Type] Article
Circadian clock modulating small molecules repurposing as inhibitors of SARS-CoV-2 M pro for pharmacological interventions in COVID-19 pandemicCOVID-19 전염병에 대한 약리학적 개입을 위한 SARS-CoV-2 M pro 억제제로 용도 변경되는 소분자를 조절하는 24시간 주기 시계Article Published on 2021-07-012022-09-11 Journal: Chronobiology international [Category] SARS, 신약개발, 치료제, [키워드] approach caused circadian clock Circadian clock-modulating molecules Coronavirus infection Coronavirus infections COVID-19 COVID-19 pandemic drug target expected health emergency inhibiting inhibitor inhibitors inhibitors of SARS-CoV-2 M pro main protease modulating MPro pandemic pharmacological intervention polyprotein Prevent protease Proteolytic processing Replication replication of SARS-CoV-2 required SARS-CoV-2 SARS-CoV-2 Mpro SARS-CoV-2 replication small molecule Spread SRT2183 targeted therapy targeting the SARS-CoV-2 Therapeutics Transcription Treatment Viral RNA [DOI] 10.1080/07420528.2021.1903027 PMC 바로가기 [Article Type] Article
Glycyrrhizic Acid for COVID-19: Findings of Targeting Pivotal Inflammatory Pathways Triggered by SARS-CoV-2Pharmacology Published on 2021-06-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acid activate acute respiratory syndrome Anti-inflammatory Anti-inflammatory effects Anti-viral Antiviral Bioinformatics analysis Biological functions causative pathogen cellular Characteristics complement conducted coronavirus Coronavirus disease 2019 COVID-19 Cytokine storms enrichment analysis Factor Factors finding glycyrrhizic acid GO analysis growth factor Host ICAM1 identify IFN IL-17 IL-6 immune system indicated inflammatory pathway inflammatory pathways inhibit Interaction interactions mechanism miRNA MMP9 Mutation network analysis network pharmacology novel pathway Pathways predominant public health crisis reactive oxygen specy receptor signaling regulate SARS-CoV-2 SARS-COV-2 infection signaling pathway significantly SOCS3 target targeted therapy targeting targets the cytokine storm therapeutic agent Therapies TLR2 TNF-α triggered Viral protein virus [DOI] 10.3389/fphar.2021.631206 PMC 바로가기 [Article Type] Pharmacology