transcriptomic – Page 9 – Communicable Diseases Research

Single-Cell RNAseq Profiling of Human γδ T Lymphocytes in Virus-Related Cancers and COVID-19 Disease

Article

Published on 2021-11-032022-10-28
Journal: Viruses [Category] COVID-19, MERS,

Expression profile of SARS‐CoV‐2 cellular entry proteins in normal oral mucosa and oral squamous cell carcinoma

정상 구강 점막 및 구강 편평 세포 암종에서 SARS-CoV-2 세포 진입 단백질의 발현 프로파일

Short Communication

Published on 2021-11-022022-09-11
Journal: Clinical and Experimental Dental Research [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술,

[키워드] ACE2 angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Atla body tissues Cell cellular entry COVID‐19 dataset datasets enzyme Evidence examined except for expression expression level expression levels expression profile expression profiles expression profiling furin head cancer HPA Human independent lesion Microarray moderate mRNA neck cancer objective oral cancer oral mucosa organ organs profile protease Proteases Protein protein expression Proteins proteomics Public relative susceptibility Result risk Risk assessment SARS‐CoV‐2 SARS‐CoV‐2 infection Squamous cell Squamous cell carcinoma tissue tissues TMPRSS2 tongue transcriptomic were used
[DOI] 10.1002/cre2.510 PMC 바로가기 [Article Type] Short Communication

Effects of Bacille Calmette Guerin (BCG) vaccination during COVID-19 infection

Research article

Published on 2021-11-012022-10-05
Journal: Computers in biology and medicine [Category] SARS, 바이오마커, 변종,

[키워드] activities acute respiratory syndrome ADORA3 analysed Analysis Bacille calmette guerin (BCG) BCG BCG vaccination caused CCL4 CCR2 CD33 Comorbidity condition contagious coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID‐19 Critical CXCL1 CXCL8 cytokine DEGs differentially expressed gene Differentially expressed genes driving drug candidate Drug molecules Effect elements enrichment analysis expression expression pattern finding functional Functional enrichment analysis Gene ontology Genes Genetic IFNg IL-17 Infection Interaction investigated ITGB2 miRNA molecular mononuclear cell more difficult Mortality network analysis Novel coronavirus pandemic pathway Pathways PBMC Peripheral blood PPI PTGS2 Regulatory Research SARS-CoV-2 SARS-COV-2 infection severity significantly Spread TFS therapeutic TLR5 transcriptomic vaccination Vaccine virus spread
[DOI] 10.1016/j.compbiomed.2021.104891 [Article Type] Research article

Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19

Article

Published on 2021-10-232022-10-30
Journal: iScience [Category] COVID-19,

Defining the Innate Immune Responses for SARS-CoV-2-Human Macrophage Interactions

SARS-CoV-2-인간 대식세포 상호작용에 대한 타고난 면역 반응 정의

Immunology

Published on 2021-10-042022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Activation activity acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affecting angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 ARDS characterized chemokine component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine storm dendritic cells dysregulation end-organ end-organ disease Evidence evidence of expression Host human monocyte human monocyte-derived macrophages IFN immune Infection Inflammation Inflammatory Innate innate immune innate immune response Interaction interferon investigated life-threatening coronavirus disease Macrophage macrophages malfunctions monocyte-macrophage Monocytes mononuclear phagocyte mononuclear phagocytes morbidities pro-inflammatory pro-inflammatory cytokine profile proteomic proteomics receptor respiratory respiratory distress Respiratory distress syndrome response robust SARS-CoV-2 SARS-CoV-2 receptor severe acute respiratory syndrome Coronavirus signaling pathways syndrome systemic inflammation the SARS-CoV-2 tissue damage transcriptomic transcriptomics type I interferon Viral viral infection viral replication virion virions while
[DOI] 10.3389/fimmu.2021.741502 PMC 바로가기 [Article Type] Immunology

Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study

전증상 SARS-CoV-2 감염 감지를 위한 급성 바이러스 감염의 혈액 전사 바이오마커: 중첩된 사례 대조군 진단 정확도 연구

Articles

Published on 2021-10-012022-09-10
Journal: The Lancet. Microbe [Category] MERS, SARS, 바이오마커, 치료기술,

[키워드] 95% CI Accuracy acute viral infection Antiviral treatment antiviral treatments article association AUROC best Biomarker Biomarkers Blood Case isolation Case-control characteristic component components Contact contribute Control controls correlated Critical database diagnostic Diagnostic accuracy distribution early phase evaluate evaluated expression facilitate finding first positive funding Genes gold gold standard health-care high risk highest host-response hypothesised identify IFI27 index cases individual infected with SARS-CoV-2 Infection IQR London median age nasopharyngeal Nasopharyngeal swab overlap participant Participants participants with SARS-CoV-2 PCR cycle PCR positivity PCR testing PCR-confirmed performed positive individuals pre-symptomatic predict Primary outcome prospective cohort provided receiver operating characteristic receiver operating characteristic curve reconstructed recruited responses RNA sample RNA sequencing RNA sequencing data sampling SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR SARS-CoV-2 PCR testing searched sensitivities sensitivity signature Spearman rank correlation Specificities specificity statistically subset Support symptom status systematic literature search tested threshold thresholds transcript transcriptional Transcriptome transcriptomic transcripts Transmission type I interferon Viral viral infection viral infections Viral load Wellcome Trust without symptoms women Z score
[DOI] 10.1016/S2666-5247(21)00146-4 PMC 바로가기 [Article Type] Articles

Network-based transcriptomic analysis identifies the genetic effect of COVID-19 to chronic kidney disease patients: A bioinformatics approach

Research article

Published on 2021-10-012022-10-05
Journal: Saudi Journal of Biological Sciences [Category] 신약개발,

[키워드] Actin Analysis analyzed approach ARHGEF12 Aspirin BCL2L1 bioinformatics CAV1 chronic Chronic kidney disease CKD Comorbidity COVID-19 COVID-19 patient DEGs detect differentially expressed gene drug E2F1 EPHB2 gene signature Genetic Health high risk HSP90B1 hub protein identify infected with SARS-CoV-2 Infection Interaction investigated ITGA2B Kidney disease microRNA molecular pathways mononuclear cell Ontology pathway Patient patients PBMC Peripheral blood PPI PRKAR2B protein-protein interaction Rapamycin regulate SARS-CoV-2 Systems biology the SARS-CoV-2 therapeutic target Threats transcription factor Transcriptional signature transcriptomic transcriptomic analysis transcriptomic data TUBB1
[DOI] 10.1016/j.sjbs.2021.06.015 [Article Type] Research article

Acute Kidney Injury in Severe COVID-19 Has Similarities to Sepsis-Associated Kidney Injury: A Multi-Omics Study

심각한 COVID-19의 급성 신장 손상은 패혈증 관련 신장 손상과 유사합니다: 다중 오믹스 연구

Article

Published on 2021-10-012022-09-12
Journal: Mayo Clinic proceedings [Category] MERS, 진단,

[키워드] Acute kidney injury adaptive age AKI Analysis analyzed antigen-presenting cells Apoptosis autophagy Autopsy cause CD3 CD4 Characteristics coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case Cytometry diagnostic died downregulation endothelial injury evaluated Evidence glomerular highlight histocompatibility complex immune individual individuals with COVID-19 Inflammation Injury interstitial investigation involved kidney less Mayo Clinic mitochondrial mitochondrial dysfunction molecular morphology necroptosis Older oxidative phosphorylation pathology pathway Pathway analysis Pathways performed peritubular peritubular capillary postmortem interval proteomic proteomics Regulatory renal Seven similarity subset T cell T helper cell therapeutic targets tissue transcriptional Transcriptome transcriptomic vascular dysfunction was performed
[DOI] 10.1016/j.mayocp.2021.07.001 PMC 바로가기 [Article Type] Article

Multi-species single-cell transcriptomic analysis of ocular compartment regulons

Article

Published on 2021-09-282022-10-04
Journal: Nature Communications [Category] 유전자 메커니즘,

Computational workflow for functional characterization of COVID-19 through secondary data analysis

보조 데이터 분석을 통한 CovID-19의 기능적 특성화를위한 계산 워크 플로

Protocol

Published on 2021-09-242022-09-10
Journal: STAR protocols [Category] SARS, 유전자 메커니즘,