Updated and Validated Pan-Coronavirus PCR Assay to Detect All Coronavirus GeneraArticle Published on 2021-04-012022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] assays circulating coronavirus CoV detect detection distribution ENhance event generate Host hosts likelihood Mild MONITOR pan-CoV PCR pandemic PCR PCR assay Prevalence primer reservoir Reservoir host Respiratory illness sensitivity Strains Surveillance tested underlie virus β-CoVs [DOI] 10.3390/v13040599 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNAArticle Published on 2021-03-292022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] binding Computational models contribute Critical domain flexible full-length Interaction Intrinsically disordered proteins macroscopic molecular motifs N protein occur offer Polymer predict Protein provide Region responsible RNA SARS-CoV-2 nucleocapsid single-genome Single-molecule biophysics underlie viral genome [DOI] 10.1038/s41467-021-21953-3 PMC 바로가기 [Article Type] Article
Neuropeptide F signaling regulates parasitoid-specific germline development and egg-laying in DrosophilaNeuropeptide F 신호 전달은 Drosophila에서 기생충 특이적 생식선 발달 및 알 낳기를 조절합니다Research Article Published on 2021-03-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activating addition Apoptosis Author caspase Cell cell proliferation cellular changes in circumvent Control decrease Defense Depression Drosophila ecological engage environmental threat female fitness germ cell germline high risk identify Immunity increase infect Infection Infectious disease Infectious diseases modifications modify neuroendocrine neuronal function Neuropeptide olfactory organism parasitoid physiological physiological mechanism predatory Previous studies previous study progeny PROTECT receptor recruit reduce reduced reduction regulate reproductive retention Signaling stem cell Stress subset survival underlie [DOI] 10.1371/journal.pgen.1009456 PMC 바로가기 [Article Type] Research Article
Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?두 폭풍 사이에 혈관 활성 펩타이드 또는 브래디키닌이 COVID-19의 심각성을 뒷받침합니까?Review Published on 2021-03-092022-08-31 Journal: Physiological Reports [Category] 바이오마커, 진단, [키워드] accumulation ACE acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition bradykinin capture cause caused complications contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 cytokine Cytokines develop disease disease severity dysregulated Evidence explain focus Inflammation mechanism microvascular permeability modulation molecular molecular mechanism neprilysin neurolysin neurotensin pandemic pathology Patient peptide peptidergic peptides primary mechanism progression provided respiratory responsible SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus severity Signaling substance P the disease Treatment underlie vascular permeability Vasoactive [DOI] 10.14814/phy2.14796 PMC 바로가기 [Article Type] Review
Lung Protection vs. Infection Resolution: Interleukin 10 Suspected of Double-Dealing in COVID-19Immunology Published on 2021-03-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] absence acute respiratory syndrome age cellular clinical phenotype contribute coronavirus coronavirus disease COVID-19 cytokine Defense Deterioration endotype etiological feature Genotype hallmark Health High-risk patients identifying IL-10 immune Immune-mediated increase increases in independent Infection infections Injury interfere interleukin Interleukin 10 lung outcome Patient Peripheral blood PROTECT protection Regulatory SARS-CoV infection SARS-CoV-2 severity Suspected thought underlie viral clearance Viral load viral spread virus while [DOI] 10.3389/fimmu.2021.602130 PMC 바로가기 [Article Type] Immunology
Ophthalmic manifestations of COVID-19; a less-appreciated yet significant challengeCOVID-19의 안과적 증상; 덜 평가되지만 중요한 도전Review Published on 2021-03-012022-09-11 Journal: International ophthalmology [Category] SARS, 치료기술, [키워드] Affect articles Awareness case sery changed chemosis conjunctivitis COVID-19 described Evidence help highlight indicate less manifestation measure mechanism nCoV nCoV-2. Novel coronavirus ocular ophthalmic Ophthalmic manifestations Optic Optic neuropathy Patient patients with COVID-19 Protective Retinitis secretion Symptom systematic literature search underlie [DOI] 10.1007/s10792-020-01664-2 PMC 바로가기 [Article Type] Review
Humoral signatures of protective and pathological SARS-CoV-2 infection in children어린이의 보호 및 병리학 SARS-CoV-2 감염의 체액 신호Article Published on 2021-03-012022-09-12 Journal: Nature Medicine [Category] MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome acute response Adults antibody Asymptomatic disease children clinical phenotype Complication convalescent coronavirus coronavirus disease COVID-19 Critical develop disease disease severity disparate Frequency functional identifying IgA IgG IgG response immune mechanism infected with SARS-CoV-2 Inflammatory Mild MIS-C Mortality neutrophil response pandemic Pathogenesis phagocyte potential mechanism Protective Respiratory failure SARS-CoV-2 SARS-CoV-2 IgG antibodies SARS-COV-2 infection serology severe disease significantly Spread syndrome These data underlie unique with mild disease [DOI] 10.1038/s41591-021-01263-3 PMC 바로가기 [Article Type] Article
Nexus between COVID-19 and periodontal disease코로나19와 치주질환의 연관성Review Published on 2021-03-012022-09-12 Journal: The Journal of international medical research [Category] SARS, 진단, [키워드] acute respiratory syndrome addition association Bacteria Bacterial Care conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 current cytokine Cytokine storm Cytokines demonstrated disease Disease progression early stages environmental factors Evidence help high risk Host host cells identify individual Inflammation Inflammatory mediators Intersection Lung disease Lungs multifactorial nexus over Patient Periodontitis plaque control Prevent pulmonary disease reducing Research resulting risk severe acute respiratory syndrome coronavirus 2 the cytokine storm thought tissue underlie understanding [DOI] 10.1177/03000605211002695 PMC 바로가기 [Article Type] Review
B cell memory: understanding COVID-19B 세포 기억: COVID-19 이해Review Published on 2021-02-092022-09-12 Journal: Immunity [Category] Fulltext, MERS, 진단, [키워드] acute respiratory syndrome B cell coronavirus COVID-19 Defense Efficacy explain help immune response Infection influence mechanism memory parameter persistence produced PROTECT protective immunity Reinfection SARS-CoV-2 underlie vaccination Vaccine [DOI] 10.1016/j.immuni.2021.01.014 PMC 바로가기 [Article Type] Review
Structure of Nonstructural Protein 1 from SARS-CoV-2SARS-CoV-2의 비구조 단백질 1의 구조Article Published on 2021-01-282022-09-11 Journal: Journal of Virology [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter Antiviral antiviral therapy carboxyl causative agent cellular city clone conformation coronavirus Coronavirus replication CoV COVID-19 COVID-19 pandemic CoVs Critical crystal structure cultured cells Deletion effective vaccine Effective vaccines element facilitate Factor Features flexible function Health high-resolution crystal structure Host host cell infecting inhibit innate immune response life cycle live-attenuated vaccines mechanism molecular mRNA degradation Mutation nonstructural protein 1 Novel coronavirus novel coronaviruses nsp1 Occurrence Pneumonia prevented promote Protein public health recruited respiratory Respiratory illness reveal SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 NSP1 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe respiratory illness shown Structure structure-function Support target therapeutic option translation turn underlie Vaccine design Vaccine development Viral viral life cycle virus virus infection Wuhan Wuhan, China X-ray X-ray crystallography [DOI] 10.1128/JVI.02019-20 PMC 바로가기 [Article Type] Article