Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study퀘르세틴, 코로나19 유발 급성 신장 손상 치료제로서의 가능성: 네트워크 약리학 및 분자 도킹 연구 기반Research Article Published on 2021-01-142022-08-13 Journal: PLoS ONE [Category] 유전자 메커니즘, [키워드] 3CL ACE2 Activation active site active sites acute kidney Acute kidney injury AKI apoptosis-related signaling pathway apoptosis-related signaling pathways binding blockade Cell Chronic kidney disease CKD clinical setting contribute Critical develop effective function functions high mortality Infection Inflammatory inhibition inhibitor Injury Interaction investigated kidney Kidney disease kidneys life cycle mechanism molecular docking network pharmacology patients with SARS-CoV-2 Potential treatment protease PROTECT protective effect Protein quercetin renal reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease signaling pathways specific treatment target targets therapeutic therapeutic agent transition Viral viral life cycle [DOI] 10.1371/journal.pone.0245209 PMC 바로가기 [Article Type] Research Article
Mapping the SARS-CoV-2–Host Protein–Protein Interactome by Affinity Purification Mass Spectrometry and Proximity-Dependent Biotin Labeling: A Rational and Straightforward Route to Discover Host-Directed Anti-SARS-CoV-2 TherapeuticsSARS-CoV-2–숙주 단백질–단백질 상호작용체 매핑(Affinity Purification Mass Spectrometry 및 Proximity-Dependent Biotin Labeling: Host-Directed Anti-SARS-CoV-2 치료제 발견을 위한 합리적이고 간단한 경로)Review Published on 2021-01-072022-09-10 Journal: International Journal of Molecular Sciences [Category] 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advent affinity Affinity purification affinity-purification mass spectrometry Antiviral approach approved drug cellular cellular processe cellular processes coronavirus coronavirus disease COVID-19 Drug discovery Drug repurposing effective emerging experiment Follow-up Generation help high resolution Host host cell host cells host protein identify Interaction interactome life cycle mapping mass mass spectrometry mirage offer outbreak PPI protein interactions protein–protein interactions protein–protein interaction proteomics proximity-dependent biotin labeling (BioID) reduce regulated respiratory route SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spectrometry target targets therapeutic option therapeutic targets Therapeutics Viral viral life cycle virus virus entry virus–host interaction virus–host interactions [DOI] 10.3390/ijms22020532 PMC 바로가기 [Article Type] Review
Cytoskeleton—a crucial key in host cell for coronavirus infectionReviews Published on 2020-12-272022-10-30 Journal: Journal of Molecular Cell Biology [Category] COVID-19, [키워드] Actin actin filaments Cell changes in coronavirus Coronavirus infection CoV CoV infection CoVs cytoskeleton expression Factors filament filament protein filaments homeostasis Host host cell host cytoskeleton Interaction interactions intermediate filaments involved membrane microtubules Modification Necrosis outcome pandemic pathology promote public health Replication Signal transduction signaling pathways target cells Transport viral life cycle [DOI] 10.1093/jmcb/mjaa042 PMC 바로가기 [Article Type] Reviews
Druggability for COVID-19: in silico discovery of potential drug compounds against nucleocapsid (N) protein of SARS-CoV-2Original Article Published on 2020-12-092022-11-01 Journal: Genomics & Informatics [Category] COVID-19, [키워드] acute respiratory syndrome analyzed antiviral drug approaches binding affinities binding affinity binding domain caused Compound conserved contagious coronavirus coronavirus disease COVID-19 creating Critical disease domain drug drug target druggability function Good Hydrogen bond identify in silico molecular docking Molecular modeling morbidity Mortality N protein nucleocapsid nucleocapsid protein offer Phylogenetic relationship Protein Region researcher RNA SARS-CoV-2 SARS-COV-2 infection selected sequence the SARS-CoV-2 these compounds Treatment Vaccine Vaccine development viral life cycle viral replication virus widespread [DOI] 10.5808/GI.2020.18.4.e43 PMC 바로가기 [Article Type] Original Article
SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stressArticle Published on 2020-12-082022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] ACE2 activated acute respiratory syndrome Analysis cellular China co-expressed Computational biology and bioinformatics coronavirus correlated COVID-19 COVID-19 pandemic dataset entry receptor enzyme epithelial cells Gene ontology Health human cell human lung IFI16 IL20 IL33 IL6 immune responses Immunity infected with SARS-CoV-2 infection process involved lung epithelial cell macrophages Mechanisms of disease Meta-analysis molecular National Pathways performed priming pro-inflammatory responses protease Regulation resulting RNA-sequencing SARS-CoV-2 SARS-CoV-2 receptor serine proteases several gene significantly species Stress the interferon therapy TMPRSS4 transmembrane transmembrane serine protease vaccination viral entry viral life cycle virus virus infection virus spike protein Wuhan [DOI] 10.1038/s41598-020-78402-2 PMC 바로가기 [Article Type] Article
Interferon‐stimulated gene products as regulators of central carbon metabolismViewpoint Published on 2020-12-012022-10-31 Journal: The Febs Journal [Category] Coronavirus, MERS, SARS, [키워드] activate analyses Antigen antiviral immune response antiviral response biochemical carbon metabolism cellular COVID‐19 eicosanoid enzyme Evidence expression GAPDH gene product help immune response immunometabolism individual inhibit inhibiting innate immune response innate immune system interfere ISG ISGs mechanism metabolic product metabolite modulate modulating NFAT nitric oxide NOS Pathways performed Protein Proteins reaction regulate RSAD2 SAM stimulate Support viperin viral disease viral infections viral life cycle Viral proteins viral replication viruses [DOI] 10.1111/febs.15625 PMC 바로가기 [Article Type] Viewpoint
Identification of Persuasive Antiviral Natural Compounds for COVID-19 by Targeting Endoribonuclease NSP15: A Structural-Bioinformatics ApproachArticle Published on 2020-12-012022-10-30 Journal: Molecules [Category] COVID-19, [키워드] active site binding Biosynthesis CDOCKER clinical investigation Combination Compound COVID-19 database docking Ecophysiology effective endoribonuclease Final Genome genomic identification investigated molecular docking molecular dynamics natural natural compounds nonstructural protein Nsp15 performed product replicate Replication residue RNA RNA virus SARS-CoV-2 SARS-CoV-2 treatment targeting viral life cycle virion Virtual screening virus [DOI] 10.3390/molecules25235657 PMC 바로가기 [Article Type] Article
Targeting the SARS-CoV2 nucleocapsid protein for potential therapeutics using immuno-informatics and structure-based drug discovery techniques면역 정보학 및 구조 기반 약물 발견 기술을 사용하여 잠재적 치료제를 위한 SARS-CoV2 뉴클레오캡시드 단백질 표적화Article Published on 2020-12-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 치료법, 치료제, [키워드] Analysis antigens approach B-cell B-cell epitope B-cell epitopes bioinformatics candidate complex coronavirus Coverage COVID-19 Critical docking Drug discovery epitope Epitope-based vaccine Epitopes help identify IFN-γ Immunity Immuno-informatics induce inhibitor leucocyte life cycle molecular dynamics Molecular dynamics simulation N protein N-protein N-terminal domain non-allergenic non-toxic nucleocapsid nucleocapsid protein Occurrence Protein ribonucleoprotein SARS-CoV2 SARS-CoV2 infection sequence Stage Structure T-cell epitope T-cell epitopes targeting the N protein therapeutic intervention therapeutic interventions therapeutic option therapeutic options Vaccine Viral viral genome viral life cycle zidovudine zidovudine triphosphate [DOI] 10.1016/j.biopha.2020.110914 PMC 바로가기 [Article Type] Article
SARS-CoV-2 viral budding and entry can be modeled using BSL-2 level virus-like particlesResearch Article Published on 2020-11-272022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, SARS, [키워드] ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome BCA, bicinchoninic acid assay BSL-2 BSL-3 BSL-3 facilities circumvent competent conditions coronavirus DAB, 3,3′-Diaminobenzidine DMEM, Dulbecco’s modified Eagle’s medium EEA1, early endosome antigen 1 effort electron microscopy (EM) ERGIC, endoplasmic reticulum–Golgi intermediary complex FBS, fetal bovine serum genetic material global pandemic globe Golgi human cell human cells inaccessible inhibitor Laboratory LAMP1, lysosomal associated membrane protein 1 majority mechanism membrane bilayer MERS coronaviruses MERS-CoV, Middle East respiratory syndrome coronavirus ORFs, open reading frames pandemic PFA, paraformaldehyde producing Research resource SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 research SARS-CoV-2 viral SARS-CoV-2 VLP SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SEM, scanning electron microscopy Spread structural protein TEM, transmission electron microscopy viral life cycle Viral protein Virology virus virus assembly virus budding virus entry Virus-like particle virus-like particle (VLP) VLPs VLPs, Virus-like particles WGA, wheat germ agglutinin Wuhan, China [DOI] 10.1074/jbc.RA120.016148 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2, Early Entry EventsReview Article Published on 2020-11-242022-10-30 Journal: Journal of Pathogens [Category] COVID-19, [키워드] ACE2 ACE2 receptor acting addition appear binding affinity Cell cell type cleavage cleavage sites competent complex conformational change conserved COVID-19 crown dependent on element furin fusion peptide host cell host tissue identification immune function insertion membrane membrane fusion membranes occur parasites protease Protein proteolytic cleavage Proteolytic processing RBM receptor receptor-binding motif replication efficiency S protein SARS-CoV-2 SARS-CoV-2 S serine 2 serine protease spike susceptible transmembrane viral life cycle virus [DOI] 10.1155/2020/9238696 PMC 바로가기 [Article Type] Review Article