viral pathogenesis – Page 9 – Communicable Diseases Research

Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection

네트워크 분석 및 전사체 프로파일링으로 SARS-CoV-2 감염에서 자가포식 및 미토콘드리아 기능 장애 식별

Genetics

Published on 2021-03-162022-08-13
Journal: Frontiers in Genetics [Category] 유전자 메커니즘,

Insights on the Structural Variations of the Furin-Like Cleavage Site Found Among the December 2019–July 2020 SARS-CoV-2 Spike Glycoprotein: A Computational Study Linking Viral Evolution and Infection

Medicine

Published on 2021-03-102022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation

SARS-CoV-2 nsp12는 IRF3 핵 전위를 억제하여 I형 인터페론 생산을 약화시킵니다

Article

Published on 2021-02-262022-09-11
Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 변종, 치료제,

[키워드] (RdRp) Activation Analysis Antiviral antiviral immunity antiviral responses attenuate COVID-19 dependent on dose-dependent manner global pandemic Host host antiviral responses IFN IFN-β immune evasion impair inducer inhibited inhibiting Innate immunity IRF3 MAVS MDA5 not dependent Nsp12 nuclear translocation overexpression pathogenic Phosphorylation poly(I:C) polymerase promoter provide RdRP respiratory respiratory RNA viruses reveal RIG-I RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp Sendai virus SeV suggested suppresse suppressed triggered type I interferon Viral viral infection viral pathogenesis Viral RNA viral RNA-dependent RNA polymerase
[DOI] 10.1038/s41423-020-00619-y PMC 바로가기 [Article Type] Article

Isolation of SARS-CoV-2 strains carrying a nucleotide mutation, leading to a stop codon in the ORF 6 protein

ORF 6 단백질에서 정지 코돈으로 이어지는 뉴클레오티드 돌연변이를 지닌 SARS-CoV-2 균주의 분리

Case Reports

Published on 2021-02-182022-09-10
Journal: Emerging Microbes & Infections [Category] SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acids antibodies Antiviral antiviral activity C terminus Complete coronavirus Course COVID-19 COVID-19 pathogenesis COVID-19 patients Deletion detrimental dual GenBank database genome sequence GISAID homology homology analysis hospital host response IFN in vitro interferon isolate Italian Lineage Mutation Neutralizing activity not affect nucleotide ORF ORF6 other coronaviruses physician Protein respiratory responsible SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 strain sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 stop codon Swab the disease the patient the SARS-CoV-2 unique Viral viral pathogenesis viral replication
[DOI] 10.1080/22221751.2021.1884003 PMC 바로가기 [Article Type] Case Reports

Plant-Derived Food Grade Substances (PDFGS) Active Against Respiratory Viruses: A Systematic Review of Non-clinical Studies

Nutrition

Published on 2021-02-092022-10-31
Journal: Frontiers in Nutrition [Category] COVID-19,

[키워드] active against activity Against alteration antiviral agent article cell entry cell line cellular damage cellular homeostasis coronavirus cytotoxicity database dysregulation Effect effective Evidence examined fatty food Functional foods functions glycoside Glycosides glycyrrhizin GRADE HCoV HCoV-NL63 herbal tea host cells Human human parainfluenza virus human population human respiratory tract IAV IBV identify in vitro include inclusion criteria infect influenza A virus influenza B inhibit initial investigated Major Mouse models NL63 pathogenic viruses pathway plant polyphenols Prevalence Prevent proliferation reduce reduction Replication reported respiratory Respiratory Tract Infection (RTI) respiratory viral infection respiratory virus Respiratory virus infections reveal review rhinovirus RSV searched selected severity Stage substance survival Viral lifecyle viral pathogenesis viral-induced virus virus titer
[DOI] 10.3389/fnut.2021.606782 PMC 바로가기 [Article Type] Nutrition

ViralLink: An integrated workflow to investigate the effect of SARS-CoV-2 on intracellular signalling and regulatory pathways

ViralLink: SARS-CoV-2가 세포 내 신호 전달 및 조절 경로에 미치는 영향을 조사하기 위한 통합 워크플로

Research Article

Published on 2021-02-032022-09-10
Journal: PLoS Computational Biology [Category] MERS, 유전자 메커니즘,

[키워드] Analysis applicability approach binding case study cellular response coronavirus dataset differentially expressed downstream Effect epithelial cells Evidence facilitate Flow globe identify in viral infected cells Infection input Interaction knowledge mechanism Pathogenesis Pathomechanisms pathway Pathways Protein provide regulatory pathway representing required Research SARS-CoV-2 SARS-CoV-2 pandemic signal Systems biology transcription factor transcription factors transcriptomics user Viral viral infection viral infections viral pathogenesis Viral protein Viral proteins virus viruses
[DOI] 10.1371/journal.pcbi.1008685 PMC 바로가기 [Article Type] Research Article

Uncovering potential host proteins and pathways that may interact with eukaryotic short linear motifs in viral proteins of MERS, SARS and SARS2 coronaviruses that infect humans

Research Article

Published on 2021-02-032022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS,

Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through analysis of Viral Genomics and Structure

Article

Published on 2021-02-012022-10-28
Journal: ArXiv [Category] COVID-19,

MicroRNAs for Virus Pathogenicity and Host Responses, Identified in SARS-CoV-2 Genomes, May Play Roles in Viral-Host Co-Evolution in Putative Zoonotic Host Species

Article

Published on 2021-01-162022-10-28
Journal: Viruses [Category] COVID-19, Fulltext, 조류인플루엔자,

Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell–cell fusion

미세융합 억제 시험: 바이러스 매개 세포-세포 융합의 항체 중화 정량화

Research Article

Published on 2021-01-152022-09-10
Journal: The Journal of General Virology [Category] SARS, 유전자 메커니즘, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibodies antibody Antibody neutralization Antibody Response Antibody responses Antibody-mediated neutralization applicability bimolecular canonical Cell cell–cell fusion cells characterized complexes consequence convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated enveloped virus fusion fusion protein GFP in vivo induce infected cells Infection inhibit inhibition test lack Live virus mAb mAbs mechanism membrane-bound mFIT monoclonal antibody multinucleated cell multinucleated cells natural infection Neutral neutralization Neutralizing antibodies Nipah virus pathogenic performed PIGS plasma quantification receptor engagement Renilla repertoire reported reporter respiratory respiratory syncytial virus RSV SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus specific antibodies Spike protein Spread Syncytia syncytia formation the cell the spike protein triggering vaccination Vaccine immunization Vaccines Viral viral pathogenesis viral spread virus Virus neutralization viruses
[DOI] 10.1099/jgv.0.001506 PMC 바로가기 [Article Type] Research Article