Development and Characterization of Magnetic SARS-CoV-2 Peptide-Imprinted PolymersArticle Published on 2021-11-062022-10-30 Journal: Nanomaterials [Category] COVID-19, [키워드] affecting approach binding affinity binding energy characterization complex condition development Dopamine Efficiency epitope imprinting evaluated fragment imprinting functional global pandemic Interaction key factor magnetic imprinted particles Molecularly imprinted polymers monomer peptide peptide imprinting Polymer problem SARS-CoV-2 selective sequence surrogate imprinting variable viral spike protein viral surface virion virus virus imprinting was selected Zika virus [DOI] 10.3390/nano11112985 PMC 바로가기 [Article Type] Article
Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contactArticle Published on 2021-11-052022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, [키워드] aggregation Antimicrobials Cell comparable Contact coronavirus COVID-19 Cytopathic effect disrupt Hypothesis Lower Microbiology MTT Particle PPE provide Respiratory Coronavirus significantly spread of COVID-19 tested Testing viability virion Virology virus [DOI] 10.1038/s41598-021-00910-6 PMC 바로가기 [Article Type] Article
1088. A Whole-Body Quantitative System Pharmacology Physiologically-Based Pharmacokinetic (QSP/PBPK) Model to Support Dose Selection of ADG20: an Extended Half-Life Monoclonal Antibody Being Developed for the Treatment of Coronavirus Disease (COVID-19)Poster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] acute respiratory syndrome Administered administration airway Ambrose ambulatory patient Andrew association being binding kinetics binding site calculated CDC Complete Concentration coronavirus Course COVID-19 criteria Developed dissociation rate distribution Donald dose employee epithelial lining evaluated expressed Extended figure human IgG1 in vitro Inc Inc. indicated initial viral load intramuscularly log maintain material median Mild Model Moderate COVID-19 Molar monoclonal antibody neutralization Other pandemic patients Pharmacology phase Post-infection profile rate constant Receptor occupancy regimen regimens representing Result SARS-CoV-2 SARS-CoV-2 viral SARS-like CoV Selection Spike protein submitted Support System Therapeutics threshold Treatment Trial Van viral clearance viral growth Viral load virion Walker Wart was used were used [DOI] 10.1093/ofid/ofab466.1282 PMC 바로가기 [Article Type] Poster Abstracts
Symptomatic post-vaccination SARS-CoV-2 infections in healthcare workers- A multicenter cohort studyObservational Study Published on 2021-11-012022-10-05 Journal: Diabetes & metabolic syndrome [Category] SARS, 임상, [키워드] 95%CI Apollo break Break through infections Breakthrough infection case-control study clinical clinical parameter Cohort COVID COVID-19 COVID-19 vaccination COVID-19 vaccine death evaluated examined group healthcare healthcare worker Healthcare workers hospital Hospitalization inactivated India Infection infections maximum Mild multicenter cohort study Nursing occurred Occurrence provided recombinant reducing retrospective SARS-CoV-2 SARS-COV-2 infection severe disease severity Sex significant difference significantly lower symptomatic symptomatic infection symptomatic SARS-CoV-2 infection vaccination Vaccine vaccine dose Vaccines Vero Cell virion were given [DOI] 10.1016/j.dsx.2021.102306 PMC 바로가기 [Article Type] Observational Study
S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategiesResearch Article Published on 2021-10-252022-10-29 Journal: PLoS Pathogens [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Antiviral antiviral activity assist association binding broad inhibitor C-terminal C-terminal region catalytic site catalytically caused cofactor complex coronavirus CpG cysteine cytoplasm Degradation dependent on determinant dinucleotide distribution domain element Endoplasmic reticulum Factors highlight HIV-1 Human immunodeficiency virus hydrophobic in viral inactive Interaction isoform KHNYN lack membrane membranes Microscopy modulate motif N-terminal RNA-binding domain nucleus PARP physical plasma membrane polymerase post-translational modification Prevent Protein provide recruitment regulate replicate Replication required residue restored RNA RNA virus RNAs SARS-CoV-2 Structure subcellular translation TRIM25 type I Vesicle viral pathogens Viral RNA virion virus virus replication ZAP [DOI] 10.1371/journal.ppat.1009726 PMC 바로가기 [Article Type] Research Article
In vivo characterization of emerging SARS-CoV-2 variant infectivity and human antibody escape potential새로운 SARS-CoV-2 변이체 감염성과 인간 항체 탈출 가능성의 생체 내 특성화Article Published on 2021-10-192022-09-11 Journal: Cell Reports [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway animals antibody antibody isotypes binding coronavirus coronavirus disease Coronavirus disease 2019 correlations COVID-19 E484K Human human coronavirus immune Immune escape in vitro in vivo in vivo modeling India Infection Interaction K417N L452R Los Angeles Lungs mice N501Y nasopharynx neutralization Neutralizing antibodies neutralizing antibody phenomenon plasma pseudovirus pseudovirus infection RBD receiving Receptor binding domain Reinfection respiratory respiratory infection SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus South Africa spreads susceptibility titers transferred Transmissibility variant variants virion virions virulence [DOI] 10.1016/j.celrep.2021.109838 PMC 바로가기 [Article Type] Article
Prime-Boost Vaccination With Covaxin/BBV152 Induces Heightened Systemic Cytokine and Chemokine ResponsesImmunology Published on 2021-10-152022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] Activation Adaptive immune response baseline CCL4 chemokine chemokines Covaxin COVID-19 CX3CL1 CXCL1 CXCL10 CXCL2 cytokine Cytokines GM-CSF healthy volunteers IFNs IFNγ IL-10 IL-12 IL-13 IL-17A IL-1α IL-1β IL-2 IL-33 IL-4 IL-5 IL-6 IL-7 inactivated induce investigated plasma pro-inflammatory cytokine recipients response robust SARS-CoV-2 SARS-CoV-2 vaccine systemic systemic immune response TNFα Type vaccination Vaccine virion [DOI] 10.3389/fimmu.2021.752397 PMC 바로가기 [Article Type] Immunology
Characterization of SARS-CoV-2 Variants N501Y.V1 and N501Y.V2 Spike on Viral Infectivity바이러스 감염에 대한 SARS-CoV-2 변이체 N501Y.V1 및 N501Y.V2 스파이크의 특성화Cellular and Infection Microbiology Published on 2021-10-132022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, [키워드] antiviral immunity B.1.1.7 B.1.351 characterization contribute coronavirus disease Coronavirus disease 2019 COVID-19 D614G demonstrated drug Efficiency endocytosis evade Host Infection Infectivity inhibitor inhibitors Mutation N501Y N501Y.V1 N501Y.V2 pathogen protease Protein pseudotype pseudovirus raised reported S protein SARS-coronavirus SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 variants sensitivity South Africa spike Spread stability stomatitis thermal stability United Kingdom variant variants vesicular stomatitis vesicular stomatitis virus virion virus wildtype [DOI] 10.3389/fcimb.2021.720357 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Receptor-Loaded Virion Endangers GPCR Signaling: Mechanistic Exploration of SARS-CoV-2 Infections and Pharmacological Implications수용체가 장착된 Virion은 GPCR 신호 전달을 위험에 빠뜨립니다: SARS-CoV-2 감염 및 약리학적 의미의 기계적 탐색Review Published on 2021-10-112022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 치료제, [키워드] ACE2 ACE2 receptor alleviate antibody Antibody therapy arrestin binding Brain Cell cell junction cellular response COVID-19 demonstrated disrupting Disruption distribution drug Drug development E protein ENhance exploration GPCR signaling hematogenous host cells impair Infection interact Interaction intestine Invasion kidney Loss of Smell loss of smell and taste lung Lungs membrane motif multiorgan injury multiple organs NRP1 other organ other organs PALS1 pathogenic PDZ interaction penetration Protein receptor required respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections susceptible Taste therapeutic strategy therapy tissue Viral viral cell entry viral endocytosis viral invasion virion virtue ZO-1 [DOI] 10.3390/ijms222010963 PMC 바로가기 [Article Type] Review
SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNASARS-COV-2 Nucleocapsid 단백질은 바이러스 게놈 RNA와 응축수를 형성한다Research Article Published on 2021-10-112022-09-10 Journal: PLoS Biology [Category] MERS, SARS, 유전자 메커니즘, 치료법, [키워드] acute respiratory syndrome coronavirus Alter asymmetric Base pairing cause coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Cross-linking Deletion disrupt form genomic RNA global health Health host cells identify in vitro infected cells Infection inhibit Interaction interactions mammalian cells mass spectrometry mechanism membrane N protein N proteins nucleocapsid pandemic proliferation Protein respiratory RNA RNA genome SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 nucleocapsid severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shape small molecule Small molecules substrate the N protein the SARS-CoV-2 the SARS-CoV-2 genome Viral viral genome viral genomic RNA viral particle Viral RNA virion while [DOI] 10.1371/journal.pbio.3001425 PMC 바로가기 [Article Type] Research Article