An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2DNA 복구-복제 인터페이스 및 SARS CoV-2를 표적으로 하는 핵산 효소에 대한 구조 기반 억제제에 대한 효율적인 화학적 스크리닝 방법Article Published on 2021-01-012022-09-11 Journal: Molecules [Category] Coronavirus, 유전자 메커니즘, [키워드] Absorption ADME ADP-ribose affinity approach approved Cancer cancer cell Cancer cells Cassandra CASSIE Cell Chemical Chemical library Chemistry classical Compound defined distribution DNA DNA replication DNA replication and repair docking drug drug design Drug discovery effective effort enzyme excretion facilitate human protein human proteins increasingly inhibitor inhibitors iterative Mac1 macrodomain mechanism metabolism molecular nonstructural protein 3 Nsp3 nucleic acid optimization PARG Pathogenesis pathway predicted problem profiles protein 3 Proteins provide repair ribose RNA SARS CoV SARS CoV-2 SARS-CoV2 Screen screening method specific inhibitor specific inhibitors Structure structures target to define [DOI] 10.1016/bs.mie.2021.09.003 PMC 바로가기 [Article Type] Article
[Control of SARS-CoV-2 in prisons]Review Published on 2021-01-012023-07-12 Journal: Semergen [Category] SARS, [키워드] Control Control de riesgo Coronavirus infections Health surveillance infecciones por coronavirus Prevención y control prevention & Prisiones prisons Risk management SARS-CoV2 Vigilancia sanitaria. [DOI] 10.1016/j.semerg.2020.10.009 PMC 바로가기 [Article Type] Review
[Impact of COVID-19 pandemic on breast and gynecologic cancers management. Experience of the Surgery Department in the Nice Anticancer Center]Comparative Study Published on 2021-01-012023-07-12 Journal: Bulletin du cancer [Category] SARS, [키워드] Breast cancer Cancer du sein Cancer gynécologique Chirurgie oncologique COVID-19 Gynecologic cancer Qualité des soins quality of care SARS-CoV2 Surgical oncology [DOI] 10.1016/j.bulcan.2020.10.013 PMC 바로가기 [Article Type] Comparative Study
Prognostic factors and predictors of outcome in patients with COVID-19 and related pneumonia: a retrospective cohort studyCOVID-19 및 관련 폐렴 환자의 예후 인자 및 예후 인자: 후향적 코호트 연구Virology Published on 2020-12-232022-09-10 Journal: Bioscience Reports [Category] MERS, 치료제, [키워드] ACE-inhibitors adopted Affect Anticoagulant treatment baseline Brescia Cancer cardiovascular risk factor cardiovascular risk factors chronic obstructive chronic obstructive pulmonary disease clinical benefit co-morbidity consecutive patient COVID-19 death demonstrated Dexamethasone diabetes died discharge disease dose drugs enoxaparin Factor Follow-up heart disease Hospital admission Hospitalization Hydroxychloroquine hypertension in some In-hospital Italy Lopinavir morbidities morbidity obstructive pulmonary disease once daily outcome patients patients died patients with COVID-19 Pneumonia predictor Prognosis pulmonary disease radiologic Respiratory failure retrospective cohort study risk of death Ritonavir SARS-CoV-2 SARS-CoV2 survival Tocilizumab treated Treatment treatment with tocilizumab variable were assessed worse prognosis [DOI] 10.1042/BSR20203455 PMC 바로가기 [Article Type] Virology
Acute Ischemic Stroke in SARS-CoV, MERS-CoV, SARS-CoV-2: Neurorehabilitation Implications of Inflammation Induced Immunological Responses Affecting Vascular SystemsNeurology Published on 2020-12-222022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] ACE—angiotensin-converting enzyme Affect AIS anticoagulation treatment Brain chronic inflammation clinician commonality coronavirus COVID COVID-19 CoVs Effect enveloped RNA virus humans hypercoaguability implication incidence induced Infection Inflammation Inflammatory cytokine storm Ischemic knowledge MERS MERS-CoV Mild neurological manifestations Neurorehabilitation physiological mechanism provide rehabilitation respiratory response risk SARS SARS-CoV SARS-CoV-2 SARS-CoV2 Severe case severe respiratory infection shown similarity stroke Symptom System the patient therapeutic intervention thrombotic risk Vascular virus [DOI] 10.3389/fneur.2020.565665 PMC 바로가기 [Article Type] Neurology
Physiology of Midkine and Its Potential Pathophysiological Role in COVID-19Physiology Published on 2020-12-222022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] angiotensin autoimmune condition autophagy cascade cause cellular clinical complication coagulative coronary syndrome COVID-19 cytokine dependent on Disseminated intravascular coagulation distress dysregulation Effect effector cells elicited facilitate fibrinolytic growth factor highlight Hyperactivation hypoxia immune immune responses include increases in induce Inflammatory literature mechanism mechanisms mediators of inflammation Midkine myocarditis NETs, autophagy neutrophil infiltration Neutrophils New coronavirus Occurrence organs pathogen clearance pathological condition pathophysiological physiological Physiology Potential pro-inflammatory cytokines pulmonary fibrosis receptor Renin replicate response role SARS-CoV2 SARS-CoV2 infection severe cases severe pneumonia similarity System target tissues Thromboembolism tissue tissue damage virus entry [DOI] 10.3389/fphys.2020.616552 PMC 바로가기 [Article Type] Physiology
Multi-resolution visualization and analysis of biomolecular networks through hierarchical community detection and web-based graphical tools계층적 커뮤니티 감지 및 웹 기반 그래픽 도구를 통한 생체 분자 네트워크의 다중 해상도 시각화 및 분석Research Article Published on 2020-12-222022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, 치료제, [키워드] Algorithm Analysis approach case study centric Community complex complex interaction conducted connectivity correlated correlation enrichment analyses enrichment analysis exploration feasible functional group hidden Hierarchical hierarchy human host Interpretation introduced performed Protein Proteins SARS-CoV2 shown user Visualization web application [DOI] 10.1371/journal.pone.0244241 PMC 바로가기 [Article Type] Research Article
Effect of COVID-19 on Lungs: Focusing on Prospective Malignant PhenotypesReview Published on 2020-12-182022-10-31 Journal: Cancers [Category] COVID-19, [키워드] ACE2 acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome affected angiotensin-converting enzyme 2 ARDS biologic Cancer cancer patient cause characteristic clinical feature Computed tomography Concentration coronavirus Coronavirus infection COVID-19 COVID-19 patient death develop disease Effect epithelial cell Existence facilitated flu Focusing Follow-up GGO glass Ground glass opacity healthcare high-risk population host cell immune system Immunopathogenesis individual induce infiltration Inflammation Inflammatory cytokine Intracellular Invasive mechanical ventilation Johns Hopkin lung lung cancer Lung fibrosis Lungs malignant management Medicine membrane protein Mortality oncogenic opacity pandemic pathophysiological conditions Patient Pneumonia pro-inflammatory cytokines Prospective protease pulmonary fibrosis resource SARS-CoV2 severe symptom simple spike glycoprotein subject survivor Symptom syndrome the patient TMPRSS2 upregulation Viral load viral outbreak virus virus particle viruses [DOI] 10.3390/cancers12123822 PMC 바로가기 [Article Type] Review
Evaluating SARS-CoV-2 Seroconversion Following Relieve of Confinement MeasuresMedicine Published on 2020-12-182022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Anti-spike Asymptomatic Community diagnosed Efficiency essential worker Evaluating full-length spike protein IgA IgA and IgG IgA antibodies IgG antibodies increase in measure Measures participant pauci/asymptomatic COVID-19 prevalence Portugal positive post-confinement community setting Prevalence provide Registered SARS-CoV-2 SARS-CoV-2 ELISA SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike SARS-CoV2 screened serological survey Seroprevalence Serosurvey spike-specific IgG subgroup University of Lisbon [DOI] 10.3389/fmed.2020.603996 PMC 바로가기 [Article Type] Medicine
An ecological study to evaluate the association of Bacillus Calmette-Guerin (BCG) vaccination on cases of SARS-CoV2 infection and mortality from COVID-19Research Article Published on 2020-12-172022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] adjusted Analysis association Bacillus Calmette-Guérin BCG BCG vaccination country COVID-19 death deaths demographics ecological Effectiveness evaluate evaluated Evidence Health information log-linear regression Measures morbidity morbidity and mortality Mortality pandemic progressed proportion reported response SARS-CoV2 SARS-CoV2 infection smoking Spread statistical the epidemic vaccination were used World Health Organization [DOI] 10.1371/journal.pone.0243707 PMC 바로가기 [Article Type] Research Article