Tocilizumab plus standard care versus standard care in patients in India with moderate to severe COVID-19-associated cytokine release syndrome (COVINTOC): an open-label, multicentre, randomised, controlled, phase 3 trial인도에서 중등도에서 중증의 COVID-19 관련 사이토카인 방출 증후군(COVINTOC) 환자에 대한 토실리주맙과 표준 치료 대 표준 치료: 공개, 다기관, 무작위 배정, 대조, 3상 시험Clinical Trial Published on 2021-05-012022-09-12 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, SARS, 임상, 진단, [키워드] 1:1 Action acute respiratory distress adverse event adverse events analyses anti-IL-6 receptor antibody assigned baseline Block randomisation Cipla clinical country COVID-19 COVID-19 progression Cytokine release syndrome death decrease discharge education effective eight Evidence FIVE Follow-up grade 3 hospital India intensive care investigated mechanical ventilation medication Ministry of Health moderate modified intention-to-treat multicentre occurred one patient Open-label participant Patient patients died phase 3 trial positive SARS-CoV-2 PCR post-hoc Prevent primary endpoint progression Racial randomised randomised controlled trial Randomly randomly assigned patients receive recruited reduced Registered registry reported Roche routine Safety Serious Adverse Events Seven severe COVID-19 shown standard care standard care group supported syndrome the primary endpoint Tocilizumab Treatment Trial with COVID-19 [DOI] 10.1016/S2213-2600(21)00081-3 PMC 바로가기 [Article Type] Clinical Trial
Multidisciplinary Safety Recommendations After Tracheostomy During COVID-19 Pandemic: State of the Art ReviewCOVID-19 팬데믹 기간 동안 기관절개술 후 다학제적 안전 권장 사항: 최첨단 검토Review Published on 2021-05-012022-09-11 Journal: Otolaryngology--Head and Neck Surgery [Category] SARS, 치료기술, [키워드] aerosol aerosol generating procedure aerosol-generating procedures Affect airway Algorithms approach approaches bleeding Care Caregivers Chronic phase Clinical practice clinician Cochrane Library complex Complication complications Consensus COVID-19 COVID-19 pandemic Deep venous thrombosis downstream DVT equipment Factors FFP3 fistula glottic stenosis Google Scholar Guidance Health Health care health care worker safety health care workers immunology Injury intubation laryngectomy laryngotracheal injury literature management manifestation Modification modifications N95 pandemic Patient patient safety patient safety and quality improvement PE Personal protective equipment Precaution precautions protocols Pulmonary embolism Quality improvement question raising recommendation recommendations respiratory review risk Safe Safety SARS SARS-CoV-2 severe COVID-19 speech state subglottic stenosis suction swallowing thrombosis tracheal tracheal stenosis tracheocutaneous fistula tracheostomy tracheostomy care tracheotomy Transmission venous Venous Thromboembolism Venous thrombosis Vigilance Vocal fold VTE [DOI] 10.1177/0194599820961990 PMC 바로가기 [Article Type] Review
Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial중증 또는 치명적인 COVID-19로 병원에 입원한 환자의 Sarilumab: 무작위 배정, 이중 맹검, 위약 대조, 3상 시험Clinical Trial Published on 2021-05-012022-09-12 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, SARS, 임상, 진단, [키워드] adverse event assessments assigned block Brazil Canada Care Clinical improvement Course COVID-19 COVID-19 severity Critical Critical disease death double-blind Efficacy EudraCT Face mask FIVE France Germany greater hazard ratio hospital immunomodulatory therapy inhibitor intensive care interleukin-6 receptor Intervention intravenous investigator Italy Japan Laboratory laboratory-confirmed SARS-CoV-2 infection mechanical ventilation median time modified intention-to-treat nasal nine no significant difference outcome outcome assessors oxygen supplementation Patient phase 3 trial Placebo placebo-controlled Pneumonia primary endpoint Proinflammatory cytokine proportion randomised Randomly receive receiving Regeneron Pharmaceuticals Registered remained required requiring supplemental oxygen Russia Safety Sanofi sarilumab screened secondary endpoint Seven Spain suggested supplemental oxygen Support survival the placebo group treatment-emergent adverse event Trial WHO with COVID-19 [DOI] 10.1016/S2213-2600(21)00099-0 PMC 바로가기 [Article Type] Clinical Trial
A randomized, double-blind, placebo-controlled phase 1 trial of inhaled and intranasal niclosamide: A broad spectrum antiviral candidate for treatment of COVID-19Research article Published on 2021-05-012022-10-05 Journal: The Lancet Regional Health - Europe [Category] 치료법, 치료제, [키워드] administration adverse event AEs airway allergy analyses anti-SARS-CoV-2 Antiviral Antiviral treatment assigned Asymptomatic clinically Cohort cohorts conducted coronavirus disease 19 COVID-19 criteria defined Denmark Diseases dose double-blind evaluated event Evidence exhibited expiratory finding FIVE Frequency funding healthy volunteer healthy volunteers Infection Inhaled intranasal Lung function niclosamide nitric oxide Patient Phase 1 phase 1 trial Placebo placebo group placebo-controlled predicted primary endpoint Pulmonary function test Randomized Randomly receiving reported resolved Safety serious AE single dose therapy Treatment Trial trials upper respiratory tract variable viral respiratory Volume Volunteer was determined [DOI] 10.1016/j.lanepe.2021.100084 [Article Type] Research article
Vaccines based on replication incompetent Ad26 viral vectors: Standardized template with key considerations for a risk/benefit assessmentReview article Published on 2021-05-012022-10-05 Journal: Vaccine [Category] SARS, 비임상, [키워드] Ad26 adenoviral vector Adenovirus baseline Benefit/Risk cellular immune responses Characteristics clinical clinical evaluation clinical study clinical trials collaboration COVID-19 vaccine database Ebola virus effective evaluate evaluated Express expression Extensive feature FIVE flexible Genetic group Human humoral key consideration mammalian cell Neutralizing antibody titer New participant Phase 3 platform pre-existing immunity profiles regimen Replication Replication-incompetent Ad26 risk Safety T cell response transgene Trial Vaccine Vaccine development vaccine immunogenicity Vaccines variety vector vectors Viral vector Viral vector vaccines working [DOI] 10.1016/j.vaccine.2020.09.018 [Article Type] Review article
Healthcare Personnel Safety During Percutaneous Tracheostomy in Patients With COVID-19: Proof-of-Concept StudyArticle Published on 2021-05-012023-07-13 Journal: Journal of Intensive Care Medicine [Category] SARS, [키워드] COVID-19 Safety tracheostomy tube [DOI] 10.1177/0885066620980384
ECMO Support and Operator Safety in the Context of COVID-19 Outbreak: A Regional Center ExperienceCommunication Published on 2021-04-302022-10-31 Journal: Membranes [Category] COVID-19, [키워드] activity acute respiratory distress air-purifying respirators ARDS caused center complex Compliance Context COVID-19 COVID-19 emergency COVID-19 outbreak doffing donning ECMO effective experience Extracorporeal extracorporeal membrane oxygenation feasible health-care healthcare worker hospital Infectious disease intensive care unit invasive Italy management Masks operator pandemic Particle Patient patients Personal protective equipment Piedmont positive Protective protocol reduced Region Regional Respiratory failure risk Safe Safety severe acute respiratory syndrome coronavirus 2 Support surgical syndrome tracheal Transport use of ECMO [DOI] 10.3390/membranes11050334 PMC 바로가기 [Article Type] Communication
People’s Willingness to Vaccinate Against COVID-19 Despite Their Safety Concerns: Twitter Poll AnalysisOriginal Paper Published on 2021-04-292022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] addressed Against Analysis antibiotic use asked Committee concern coronavirus Course COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines demonstrated detrimental effect Digital Efficacy effort elevated Emergency facilitated health emergency Hesitancy human papillomavirus incidence International international public health maintain media mitigate Nonpharmaceutical interventions objective opinion pandemic Perception platform provided public health question real time researcher Result Safety SARS-CoV-2 social media Spread spread of COVID-19 survey the disease Twitter undergo vaccination Vaccination hesitancy vaccination willingness Vaccine Vaccine confidence Vaccine hesitancy Validity Willingness World Health Organization’ [DOI] 10.2196/28973 PMC 바로가기 [Article Type] Original Paper
Assessment of Knowledge, Attitude, and Practice of Security and Safety Workers Toward the COVID-19 Pandemic: A Cross-Sectional StudyPublic Health Published on 2021-04-282022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] age assessment Attitude Attitudes conducted COVID-19 COVID-19 pandemic cross-sectional survey employment female Government information KAP knowledge majority MOST pandemic participant Participants positive attitude Practice practices predictor question questionnaire Randomly reflected Safe Safety Saudi Arabia security television worker [DOI] 10.3389/fpubh.2021.631717 PMC 바로가기 [Article Type] Public Health
Validation of the Withings ScanWatch as a Wrist-Worn Reflective Pulse Oximeter: Prospective Interventional Clinical StudyWithings ScanWatch를 손목에 착용하는 반사형 맥박 산소 농도계로 검증: 전향적 중재 임상 연구Clinical Trial Published on 2021-04-262022-09-12 Journal: Journal of Medical Internet Research [Category] MERS, 임상, 진단, [키워드] 95% CI Accuracy adverse event adverse events Analysis arterial oxygen saturation association biases Bland blood sample Blood samples chronic obstructive chronic obstructive pulmonary disease clinical clinical study collected condition connected watch COPD correlation COVID-19 decrease Effect hands healthy Hypoxemia hypoxia hypoxic conditions Inconclusive Indicator mass meet Mild moderate MONITOR Neural network objective obstructive pulmonary disease occur oximeter oxygen oxygen saturation participant Pearson correlation coefficient Prospective pulmonary disease pulse Pulse oximeter pulse oximetry pulse oxygen saturation Radiometer reflective pulse oximeter Registration removal reported respiratory Respiratory disease respiratory diseases Result Safety single-blind sleep apnea sleep apnea syndrome SpO2 Stage validation wearable Withings ScanWatch [DOI] 10.2196/27503 PMC 바로가기 [Article Type] Clinical Trial