immune responses – Page 94 – Communicable Diseases Research

Generation of Chicken IgY against SARS-COV-2 Spike Protein and Epitope Mapping

Research Article

Published on 2020-10-172022-10-29
Journal: Journal of Immunology Research [Category] COVID-19, MERS, SARS,

[키워드] 3D structure acute respiratory syndrome administration antibody Antibody binding approved drugs caused chicken clinician coronavirus COVID-19 cross-reactive enzyme epitope epitope mapping Epitopes exhibited feasibility FIVE Generation global pandemic Health immune responses immunization Immunoglobulin immunoreactivity include intranasal linear epitope Local mapping neutralizing antibody overlap physically Protein proteolytic proteolytic cleavage raised repurposing respiratory infections risk S trimer S1/S2 S1/S2 cleavage S1/S2 cleavage site SARS-CoV S SARS-CoV-2 SARS-CoV-2 S scientist spike subsequent Therapeutic approach therapy treating SARS-CoV-2 infection Vaccine viral cell virus-cell membrane fusion
[DOI] 10.1155/2020/9465398 PMC 바로가기 [Article Type] Research Article

Design of novel multiepitope constructs-based peptide vaccine against the structural S, N and M proteins of human COVID-19 using immunoinformatics analysis

면역정보학 분석을 이용한 인간 코로나19의 구조적 S, N, M 단백질에 대한 새로운 다중 에피토프 구조 기반 펩타이드 백신 설계

Research Article

Published on 2020-10-152022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS,

[키워드] 3D structure acute respiratory syndrome adopted allergen Analysis analyzed approach B-cell B-cell epitope B-cell epitopes BepiPred Betacoronavirus binding calculated candidate Candidates causative agent cellular immune responses center China CDC Chinese clade cleavage contribute Control Coronaviridae Coverage COVID-19 CTL CTL epitope demonstrated develop disease control domain Efficiency elicit Ellipro epitope Epitopes GalexyPepDock highest HTL HTL epitopes humoral Hypothesis I-TASSER identify IEDB immune responses immunodominant immunoinformatics in silico in vivo Interaction linear MHC multiepitope vaccine N and M NCBI database NetCTL NetMHCpan novel Betacoronavirus peptide predicted proteasomal Protein RBD Receptor-binding domain regions reported respiratory S protein S, N and M proteins SARS-CoV-2 SARS-CoV-2 peptide vaccine SARS-CoV-2 susceptibility sequence Severe acute respiratory syndrome strong interactions Tap transport/proteasomal cleavage These data TLR TLRs TLRs 2, 3 and 4 Transport Vaccination strategies Vaccine virus was obtained
[DOI] 10.1371/journal.pone.0240577 PMC 바로가기 [Article Type] Research Article

Unique immunological profile in patients with COVID-19

COVID-19 환자의 독특한 면역 프로필

Clinical Trial

Published on 2020-10-152022-08-13
Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 바이오마커, 임상, 치료제,

[키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Analysis CD56 CD57 CD69 CD8 Cell contraction Coronavirus-2 COVID-19 COVID-19 patient Cytokines Deceased disease distribution driven by effective expansion expression FcεRIγ Frequency healthy subject healthy subjects help host immunity IL-1β IL-6 IL-8 IL6 immature immune response immune responses Immunoglobulin immunological profile Increased Infection Inflammatory cytokine Inflammatory cytokines interferon Interleukins lectin Lymphocytes monocyte Monocytes Monocytes and macrophages mucin natural killer NK cell NK cells NKG2D outcome overexpressed Patient patients with COVID-19 PD-1 performed Peripheral blood peripheral blood lymphocytes positive cell positive cells programmed cell death programmed cell death protein proportion Protein reduced respiratory restoration SARS-CoV-2 SARS-COV-2 infection secrete secreted secretion Serum level Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 severe SARS severe SARS-CoV-2 sialic acid Survivors T cell T cells T-cell TIM-3 Treatment unique viral infection with COVID-19
[DOI] 10.1038/s41423-020-00557-9 PMC 바로가기 [Article Type] Clinical Trial

Revisiting the Immune Balance Theory: A Neurological Insight Into the Epidemic of COVID-19 and Its Alike

Neurology

Published on 2020-10-152022-11-01
Journal: Frontiers in Neurology [Category] COVID-19,

[키워드] Activation Astrocyte balance Brain cause caused Central nervous system change CNS complex coronavirus Coronaviruses COVID-19 COVID-19 patient Cytokine storm disease disrupt Effect Encephalitis Fever immune Immune cell immune imbalance immune responses Inflammation insight MERS-CoV microglia Middle East multiple organ failure neurodegenerative neuroinvasion Neuroinvasive neurological Neurological complications neurological manifestation Neuropsychiatric neurotropic pandemic of COVID-19 Pneumonia provide raise respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Spread synaptic Transport typical symptoms virus
[DOI] 10.3389/fneur.2020.566680 PMC 바로가기 [Article Type] Neurology

Evolutionary medical insights into the SARS-CoV-2 pandemic

Commentary

Published on 2020-10-142022-11-01
Journal: Evolution, Medicine, and Public Health [Category] COVID-19,

[키워드] adaptive age amlodipine Analysis association Asymptomatic caused Coagulation coronavirus COVID-19 COVID-19 mortality driven by dysregulated Efficacy Evidence explain Factor faster females high mortality humans immune immune defense immune responses immune system immune systems Immunity infectious agents Inflammation interferon interferons less male mammal Mortality overactive pandemic pathology Phenotypes pre-symptomatic Previous studies promote provide reduced risk SARS-CoV-2 senesce Sex shown Side effect SNPs Spread suppress Symptom the SARS-CoV-2 Treatment virus younger people
[DOI] 10.1093/emph/eoaa036 PMC 바로가기 [Article Type] Commentary

Tissue Proteases and Immune Responses: Influencing Factors of COVID-19 Severity and Mortality

Review

Published on 2020-10-062022-10-28
Journal: Pathogens [Category] COVID-19,

The Current Status of COVID-19 Vaccines

Genome Editing

Published on 2020-10-022022-10-31
Journal: Frontiers in Genome Editing [Category] COVID-19,

Acute hypertriglyceridemia in patients with COVID-19 receiving tocilizumab

토실리주맙을 투여받는 COVID-19 환자의 급성 고중성지방혈증

Comment

Published on 2020-10-012022-09-12
Journal: Journal of medical virology [Category] MERS, SARS, 진단,

[키워드] Abstract coronavirus disease disease control immune immune responses immunodulators interleukin patients with COVID-19 receiving Tocilizumab virus virus classification
[DOI] 10.1002/jmv.25907 PMC 바로가기 [Article Type] Comment

COVID-19 in tuberculosis patients: A report of three cases

Case Reports

Published on 2020-10-012023-07-06
Journal: Journal of medical virology [Category] SARS,

[키워드] coronavirus immune responses Infection
[DOI] 10.1002/jmv.25943 PMC 바로가기 [Article Type] Case Reports

Intermittent fasting, a possible priming tool for host defense against SARS-CoV-2 infection: Crosstalk among calorie restriction, autophagy and immune response

Review

Published on 2020-10-012023-07-06
Journal: Immunology letters [Category] SARS,

[키워드] autophagy calorie restriction COVID-19 Cytokine storm immune responses SARS-CoV-2
[DOI] 10.1016/j.imlet.2020.07.001 PMC 바로가기 [Article Type] Review