The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases인간 질병에 대한 단백질 바이오마커에 대한 DNA 메틸화 및 유전적 변이의 상대적 기여도Research Article Published on 2017-09-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adjusted Affect allele alteration analyses analyzed association Biomarker Biomarkers Cancer cardiovascular disease cardiovascular diseases caused copy CXCL11 CXCL9 disease disease pathogenesis disease status disease-associated Diseases DNA methylation DNA methylation level DNA methylation levels driven by Effect effect size effect sizes effective environmental factor environmental factors Epigenetic Evidence expression expression patterns Factor Genes Genetic Genetic variant genetic variants Genetic variation Genome Genome-wide association study genomic position GWAS Human human disease human diseases IL-12 IL-18 Inflammation loci locus Modification MOST NLRC5 overlapped Pathogenesis performed phenotypic Protein risk smoking SNP SNPs trans unique Variation were measured while [DOI] 10.1371/journal.pgen.1007005 PMC 바로가기 [Article Type] Research Article
Group B streptococcus vaccination in pregnant women with or without HIV in Africa: a non-randomised phase 2, open-label, multicentre trial아프리카에서 HIV가 있거나 없는 임산부를 대상으로 한 그룹 B 연쇄상구균 백신: 비무작위 2상, 공개 라벨, 다기관 시험Articles Published on 2016-05-012022-09-06 Journal: The Lancet. Infectious Diseases [Category] Communicable Disease, [키워드] (no infection adverse event Adverse reaction Analysis analysis Antenatal antibody antibody concentration Antibody concentrations Birth Blood CD4 cell Cell clinics collected Concentration died disease dose enrolled event finding Fold change Follow-up funding geometric geometric mean gestation GlaxoSmithKline group groups HIV HIV infection HIV-uninfected immunogenic immunogenicity increased risk Infant Infants Infection intramuscularly invasive Italy less life maternal antibody Medical Research Council Meningeal mother multicentre Neonate Neonates no infection Novartis Open-label participant Pathogens Phase 2 placental pregnant women Primary outcome Primary outcomes Protective provided recruited reduce Registered reported respiratory resulting safety analyses serotype-specific serotypes serum serum sample Siena South Africa stillborn the vaccine three group three groups transfer transferred Trial trivalent unit vaccination Vaccine Wellcome Trust were measured with HIV women [DOI] 10.1016/S1473-3099(15)00484-3 PMC 바로가기 [Article Type] Articles
Daily consumption of ready-to-use peanut-based therapeutic food increased fat free mass, improved anemic status but has no impact on the zinc status of people living with HIV/AIDS: a randomized controlled trial바로 사용할 수 있는 땅콩 기반 치료 식품을 매일 섭취하면 무지방 질량이 증가하고 빈혈 상태가 개선되지만 HIV/AIDS 감염자의 아연 상태에는 영향을 미치지 않습니다. 무작위 대조 시험Research Article Published on 2016-01-042022-08-09 Journal: BMC Public Health [Category] 임상, [키워드] adjusted Admission affected AIDS Anemia anemic anemic status ART atomic absorption spectrometry Bio-Impedance Analysis Body body composition body fat body weight both groups clinical trial comparable Concentration conducted Control control group Controlled Controlled clinical trial CRP Daily daily recommended intake deficiency discharge energy fat Fat free mass fat-free mass food group hemoglobin HIV/AIDS Hospitalized Improving Individual dietary Infection iron Malnutrition measure muscle mass on admission patients percentage body fat plasma plasma zinc concentration PLWH positive Randomized controlled trial Randomly ready-to-use therapeutic food receive Recommended Dietary Allowances Registered remained Result Senegal severe malnutrition significantly standard hospital diet status sub-Saharan Africa the patient therapeutic Therapeutic food Treatment was determined was measured were measured Zinc zinc deficiency α1-AGP [DOI] 10.1186/s12889-015-2639-8 PMC 바로가기 [Article Type] Research Article
Attenuation of Mouse Hepatitis Virus by Deletion of the LLRKxGxKG Region of Nsp1Research Article Published on 2013-04-082022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] attenuation C57BL/6 cells changes in conserved coronavirus Deletion different domain Gene Expression growth human diseases in vitro in vivo inhibited mechanism MHV MHV-A59 mice mouse mutant virus positive-sense promoters Region reporter Research responsible reverse genetic system RNA virus shown vaccinia virus was reduced were measured wild-type virus [DOI] 10.1371/journal.pone.0061166 PMC 바로가기 [Article Type] Research Article
Potent and persistent antibody responses against the receptor-binding domain of SARS-CoV spike protein in recovered patientsResearch Published on 2010-11-042022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] animal model Anti-RBD antibody Antibody Response antigenicity approach assays characterized diagnostic ELISA Follow-up found Human immunogenic included induce Neutralizing activity Neutralizing antibodies neutralizing antibody potent protective response Protein purified RBD RBD of SARS-CoV RBD-specific antibody recovered patient Result robust S protein SARS patient SARS-CoV SARS-CoV spike protein serum sample the antibody response the RBD the receptor-binding domain Vaccine were measured [DOI] 10.1186/1743-422X-7-299 PMC 바로가기 [Article Type] Research