Zn 2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell CultureResearch Article Published on 2010-11-042022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activity Antiviral arteritis arterivirus Author binding block both viruses catalyzed Cell Cell culture Combination complex Complexes Concentration described divalent cation E. coli eliminating enzyme equine found function host proteins impair in vitro activity in vitro study include Increased Increasing Infected Influenza virus inhibit inhibited inhibitory effect Ionophore molecular nidovirus nidovirus Nsp12 Nsp9 Pathogens plasma Poliovirus polymerases polyprotein polyproteins Proteolytic processing protocol provide purified RdRP RdRps reduced related Replication replication complex replicative Research reversed RNA RNA synthesis RNA viruses RNA-dependent RNA polymerase RTC SARS-coronavirus SARS-CoV target Transcription Transport variety Viral RNA virus virus Zinc Zn [DOI] 10.1371/journal.ppat.1001176 PMC 바로가기 [Article Type] Research Article
A Niche for Infectious Disease in Environmental Health: Rethinking the Toxicological ParadigmReview Published on 2010-08-122023-08-30 Journal: Environmental health perspectives [Category] E형 간염, [키워드] Biomarkers Colon cancer conceptual framework environmental health Infectious disease Liver cancer NIEHS Pathogens toxicology [DOI] 10.1289/ehp.0901866 PMC 바로가기 [Article Type] Review
Human airway epithelial cell culture to identify new respiratory viruses: Coronavirus NL63 as a modelArticle Published on 2008-12-052022-11-01 Journal: Journal of virological methods [Category] Coronavirus, [키워드] airway amplification amplify antibody approach approaches Cell culture cell line clinical samples coronavirus CPE, cytopathic effect Culture culture supernatant cultures Cytopathic effect described detect determine different time point epithelial evaluated experiment HAE HAE culture HAE, human airway epithelium HCoV-NL63 HCoV-NL63, human coronavirus NL63 Human identify Infection lack molecular NL63 nucleic acid pathogen Pathogens Propagation reagent reported respiratory pathogen respiratory viral respiratory virus SARS-CoV, severe acute respiratory syndrome coronavirus secretion sequence Sequence analysis TEM TEM, transmission electron microscopy Transcriptome transmission electron microscopy variety virus Whole transcriptome amplification WTA, whole transcriptome amplification [DOI] 10.1016/j.jviromet.2008.10.022 PMC 바로가기 [Article Type] Article
Optimization of proteomic sample preparation procedures for comprehensive protein characterization of pathogenic systemsArticle Published on 2008-12-012023-06-10 Journal: Journal of biomolecular techniques : JBT [Category] 원숭이두창, [키워드] :mass spectrometry Methods Pathogens proteomics sample preparation. PMC 바로가기
Identification of Upper Respiratory Tract Pathogens Using Electrochemical Detection on an Oligonucleotide MicroarrayResearch Article Published on 2007-09-262022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 229E Adenovirus amplification Analysis Antibiotics automated bacterial pathogen benefit Bordetella pertussis Chlamydia pneumoniae clinical symptom coronavirus detect detection diagnostics different ECD electrical equipment flexible form genotyping identification identify influenza A involved iterative Microarray Multiple Mycoplasma pneumoniae OC43 oligonucleotide optical pathogen Pathogens platform probe reactive respiratory respiratory syncytial virus Sensitivity and specificity Streptococcus pyogenes tract Treatment upper upper respiratory infection viral infections viral pathogen [DOI] 10.1371/journal.pone.0000924 PMC 바로가기 [Article Type] Research Article
Risk Assessment of Arsenic Mitigation Options in BangladeshOriginal Paper Published on 2006-09-012023-08-30 Journal: Journal of Health, Population, and Nutrition [Category] E형 간염, [키워드] arsenic Arsenic mitigation: Water pollution DALYs Pathogens Risk assessment Technology choice: Bangladesh water quality Water Supply PMC 바로가기 [Article Type] Original Paper
Genetic Analysis of the Capsular Biosynthetic Locus from All 90 Pneumococcal Serotypes모든 90개의 폐렴구균 혈청형에서 피막 생합성 유전자좌의 유전적 분석Research Article Published on 2006-03-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis antigenic variation Antisera bacterial pathogen bacterial polysaccharide bacterial polysaccharide biosynthesis system bacterial polysaccharide diversity Bentley Blood capsular biosynthesis capsular biosynthesis gene capsular biosynthesis genes capsular biosynthetic gene capsular biosynthetic genes capsular gene capsular polysaccharide capsular polysaccharide structures capsular polysaccharides capsular serotype Capsule children chromosomal coated coding complement Complete determined different disease DNA DNA sequence effective protein-conjugated Effective vaccines evade Evolution Express genetics host antibodies host antibody human immune response immunochemically immunogenic immunological reactivity introduced invasive bacterial pathogen knowledge locus mechanism molecular Pathogens pneumococcal disease pneumococcus polysaccharide capsule polysaccharide structure polysaccharide vaccine PROTECT S. pneumoniae selected sequence sequences sera serological profile serological profiles serotype serotypes Seven Streptococcus pneumoniae survival target The United States total size United States virulence [DOI] 10.1371/journal.pgen.0020031 PMC 바로가기 [Article Type] Research Article
Emerging viral diseases and infectious disease risksArticle Published on 2006-01-272023-05-31 Journal: Haemophilia : the official journal of the World Fe [Category] 조류인플루엔자, [키워드] Avian Influenza haemophilia Human immunodeficiency virus Pathogens Severe acute respiratory syndrome West Nile Virus [DOI] 10.1111/j.1365-2516.2006.01194.x PMC 바로가기
SARS Antibody Test for SerosurveillanceResearch Published on 2004-09-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome Blood can be used characterized coronavirus detected disease disease transmission Donor ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope mapping healthcare worker healthy helping hospital identify immunoassay Infection M protein membrane N protein nosocomial nucleocapsid protein onset of fever Pathogens peptide peptide-based remained Research retrospective Retrospective study S protein SARS patients SARS-CoV sensitivity Sensitivity and specificity sequence Seroconversion serologic test serum sample specificity Standardization synthetic peptide Taiwan Test treated was used [DOI] 10.3201/eid1009.040101 PMC 바로가기 [Article Type] Research
Viral Discovery and Sequence Recovery Using DNA MicroarraysResearch Article Published on 2003-11-172022-10-28 Journal: PLoS Biology [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome approach approach CENTRAL cloned Combination conserved coronavirus description detect DNA DNA microarray elements GenBank hybridized identify Infectious disease limitation Microarray new virus Novel coronavirus novel virus outbreak Pathogens physically platform SARS patient SARS virus sequence sequenced viral genome viral sequence virus virus virus genome [DOI] 10.1371/journal.pbio.0000002 PMC 바로가기 [Article Type] Research Article