controls
[용어속성] abnormalities
Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway
류마티스 관절염의 인간 유전학은 CD40 신호 전달 경로의 고처리량 약물 검사를 안내합니다
Research Article
[키워드] activated
After
allele
Analysis
approved drug
Arthritis
association
Author
B cells
B lymphocyte
B lymphocytes
Biology
can be used
CD19+
CD40
CD40 ligand
CD40 signaling
Cell
cell line
chemical compounds
clinical care
coding
Combination
complex
Compound
consequence
controls
correlation
counter
deep sequencing
develop
disease
drug
Drug discovery
drugs
effort
eQTL
ExoN
exonic
explain
expression
finding
Follow-up
gain-of-function
Genetic
genetic findings
Genome-wide association studies
Genome-wide association study
genotyping
guide
GWAS
healthy control
homozygous
Human
Human genetics
identify
implicated
increase
individuals
Infection
Inflammation
inhibit
inhibitor
loci
locus
lymphocyte
Lymphocytes
mononuclear cell
mononuclear cells
mouse
NF-kB
NF-κB
NF-κB signaling
non-risk allele
observé
p65
pathway
Patient
Peripheral blood
Peripheral blood mononuclear cells
Phosphorylation
Protein
Quantitative
RA
RELA
reporter
retroviral
Rheumatoid
rheumatoid arthritis
risk
risk allele
Screen
second
Sequencing
seropositive
Signaling
single SNP
small molecule
Small molecules
small-molecule screen
subject
subunit
therapy
trait
traits
transcription factor
treat
variant
while
[DOI] 10.1371/journal.pgen.1003487 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1003487 PMC 바로가기 [Article Type] Research Article
miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1
miR-199a-5p는 조직 손상에 대한 섬유성 반응 동안 상향 조절되고 카베올린-1을 표적으로 하여 TGF베타 유도 폐 섬유아세포 활성화를 매개합니다
Research Article
[키워드] a major
Activation
addition
Author
best
Bile duct
Biology
Bleomycin
CAV1
Cell
cell type
cellular
cellular processes
characterized
chronic
class
complex diseases
contributing to
controls
Critical
current therapy
demonstrated
deregulation
develop
different
differentiation
disease
Disease progression
Diseases
disorder
driving
dysregulation
ectopic expression
Effect
expression
failure
fibroblast
fibroblasts
fibrosis
final common pathway
foci
form
found
histologic
identify
idiopathic
Invasion
investigated
IPF
kidney
led to
life
liver
Liver fibrosis
lung
Lung diseases
Lung fibrosis
Lungs
mechanism
mediator
MicroRNAs
Migration
miRNA
miRNA expression
miRNAs
morbidity
morbidity and mortality
mouse model
Myofibroblast
non-coding RNA
Organ failure
organ function
pathogenic
pathogenic mechanism
pathogenic mechanisms
Patient
patients
performed
poor prognosis
proliferation
promote
pulmonary fibrosis
reducing
response
response rate
responsible
scar
scar tissue
Signaling
significantly increased
strain
susceptibility
targeting
TGFβ
therapeutic potency
therapeutic strategy
thought
tissue
treat
ureteral obstruction
[DOI] 10.1371/journal.pgen.1003291 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1003291 PMC 바로가기 [Article Type] Research Article
ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy
ImmunoChip 연구는 기면증에서 T 세포에 대한 항원 제시를 의미합니다
Research Article
[키워드] addition
Alpha
Antigen presentation
antigen processing
Author
Autoimmune
autoimmune and inflammatory diseases
autoimmune attack
Autoimmune disease
Cathepsin H
chromosome
chromosome 6
class
compared
Consensus
Control
controls
CTSH
deficiency
disease pathogenesis
disease risk
encoded protein
encoded proteins
environmental exposure
European
Gene
Genes
genome-wide significance
genotyped
genotyping
high-density genotyping platform
HLA
HLA class II
HLA DQB1*06:02
Human
human leukocyte antigen
hypocretin cells
ImmunoChip
immunological synapse
implicated
in addition to
individual
inflammatory disease
Inflammatory diseases
Interaction
leukocyte
Ligand
loci
mechanism
Narcolepsy
narcolepsy-hypocretin deficiency
OX40L
pathophysiology
pathway
post-infectious autoimmune
presentation
progression
recent
selective
significantly
study variant
Support
susceptibility
T cell
T cell receptor
T cell response
T cells
the disease
TNFSF4
TNFSF4/OX40L
tumor necrosis
tumor necrosis factor
unique
variant
variants
while
[DOI] 10.1371/journal.pgen.1003270 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1003270 PMC 바로가기 [Article Type] Research Article
A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci
6개의 1형 당뇨병 코호트에 대한 게놈 전체 메타 분석으로 여러 관련 유전자좌 식별
Research Article
[키워드] ADCY3
affected
association
Author
C6orf120
CENPO
chromosomal
combined cohort
contributing to
controls
dataset
diabete
diabetes
disease
DLL1
DNAJC27
DNMT3A
domain
EFR3B
examined
excess
FAM120B
Follow-up
Gene
gene network
gene networks
Genes
Genetic
genetic component
genetic loci
genetic screening
Genome
Genome-wide association studies
Genome-wide association study
genome-wide significance
genotyped
GWAS
homolog
hypotheses
identify
Impact
independent
intergenic region
intronic region
investigator
investigators
Linkage disequilibrium
LMO7
LOC154449
loci
meta-analyses
Meta-analysis
Multiple
NCOA1
Pathogenesis
PHF10
POMC
Protein
PSMB1
reached
recent finding
Region
replicated
risk
risk for disease
significantly
SNP
SNPs
susceptibility
T1D
TBP
the disease
Type
Type 1 diabetes
variant
variants
WDR27
[DOI] 10.1371/journal.pgen.1002293 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1002293 PMC 바로가기 [Article Type] Research Article
Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease
대규모 유전자 중심 분석으로 관상동맥 질환에 대한 새로운 변종 식별
Research Article
[키워드] ABCG5
ABCG8
aetiology
Affect
allele
Analysis
array
Artery
Asians
association
association tests
Author
biochemical
CAD
candidate gene
cardiovascular disease
cellular
characterized
COL4A1
COL4A2
common variants
complement
conducted
Control
controls
Coronary
Coronary artery
Coronary artery disease
custom-designed array
customised gene array
CYP17A1
disease
Effect
European
Europeans
Evidence
evidence of
examined
except for
found
Frequency
function
functional variant
functional variants
Gene
Gene Expression
Genes
Genetic
Genetic variant
genome-wide association
genotyped
GWA
heart disease
help
heterogeneity
identify
IL5
LIPA
loci
low frequency
LPA
majority
mechanism
not differ
novel
novel association
novel associations
Odds ratio
Potential
potential mechanism
potential mechanisms
replicate
Replication
reported
risk
risk factor
South
South Asian
suggested
supported
susceptibility
susceptibility loci
target
tested
therapeutic interventions
TRIB1
variant
variants
Vascular
ZC3HC1
[DOI] 10.1371/journal.pgen.1002260 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1002260 PMC 바로가기 [Article Type] Research Article
The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese
Research Article
[키워드] acute respiratory syndrome
Admission
Affect
antiviral action
association
Beijing
Chinese
controls
death
examined
G allele
Genotype
Hong Kong
increased risk
individual
Inflammation
intensive care unit
IP-10
outcome
Pathogenesis
polymorphism
RANTES
Replication
Result
risk of death
SARS patient
susceptibility
tested
[DOI] 10.1186/1471-2334-7-50 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1186/1471-2334-7-50 PMC 바로가기 [Article Type] Research Article
Molecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)
Research Article
[키워드] 2003
acute respiratory syndrome
approach
Asia
biological systems
Blood
caused
change
changes in
Clinical severity
Clustering
Control
controls
coronavirus
correlated
disease
distress
Epidemic
expression profile
Gene
Gene Expression
Genes
Host
human disease
immunopathological damage
Innate immunity
International
involved
mortality rate
Novel coronavirus
pathophysiology
Patient
Peripheral blood
Pulmonary infection
recovering patient
regulated
reported
Result
SARS patient
SARS patients
SARS-CoV
several gene
severe
severity
significantly
Spread
upregulated
while
World Health Organization
[DOI] 10.1186/1471-2164-6-132 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1186/1471-2164-6-132 PMC 바로가기 [Article Type] Research Article
Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS
Research
[키워드] abnormality
acute phase
acute respiratory syndrome
alveolar cell
alveolar macrophage
Alveolar macrophages
BALF
Bronchoalveolar lavage
Bronchoalveolar lavage fluid
CD4/CD8
CD8
cell count
cells
clearance
compared
Computed tomography
controls
coronavirus
correlated
Course
cytokine
Cytokines
described
desquamation
detected
determine
dysregulation
Factor
Fever
High-resolution
High-resolution CT
HRCT
hyaline membrane formation
IL-6
IL-8
independent
infiltration
Inflammatory
investigated
lung
Lung inflammation
MCP-1
Microscopy
mononuclear cell
non-randomized
occur
Particle
Patient
patients
persistence
persistent
Plasma cytokine
profiles
RANTES
Resolution
Result
Retrospective analysis
SARS
SARS patient
significantly
subpopulations
T lymphocyte
T-cell
therapy
TNF-α
[DOI] 10.1186/1465-9921-6-42 PMC 바로가기 [Article Type] Research
[DOI] 10.1186/1465-9921-6-42 PMC 바로가기 [Article Type] Research
Detection of SARS Coronavirus in Patients with Suspected SARS
Research
[키워드] acute respiratory syndrome
Antibody Response
case
clinically
compared
controls
detectable
detected
detection
diagnosed
Diagnosis
Epidemiology
investigated
Pathogenesis
Patient
patients
peaked
Rate
remained
Research
RNA
SARS
SARS Coronavirus
SARS-CoV
secretion
Serologic response
serum sample
Severe acute respiratory syndrome
specimen
specimens
Sputum sample
Stool
Suspected
throat swabs
Transmission
Urine
viral culture
Viral RNA
virus
[DOI] 10.3201/eid1002.030610 PMC 바로가기 [Article Type] Research
[DOI] 10.3201/eid1002.030610 PMC 바로가기 [Article Type] Research