Combination treatments with hydroxychloroquine and azithromycin are compatible with the therapeutic induction of anticancer immune responses하이드록시클로로퀸과 아지스로마이신의 병용 치료는 항암 면역 반응의 치료 유도와 양립 가능합니다.Article Published on 2020-07-082022-09-11 Journal: Oncoimmunology [Category] SARS, 바이오마커, 비임상, 신약개발, 임상, [키워드] administration Affect antibiotic anticancer antimalarial antimalarial drug appear autophagic flux AZI Azithromycin blockade body weight breath Campus Cancer Cancer patients cancers cisplatin clinical trial Combination combination therapy COVID-19 crizotinib curative dose doses Gustave Roussy HCQ Hydroxychloroquine immune immune checkpoint immune response immune responses immunogenic cell death Immunotherapy indicated inducer interfere investigated lung cancer mice not affect oxaliplatin PD-1 preclinical study reduction in regimen SARS-CoV-2 therapeutic treated Treatment Tumor tumor growth utility [DOI] 10.1080/2162402X.2020.1789284 PMC 바로가기 [Article Type] Article
COVID-19 Coronavirus Vaccine Design Using Reverse Vaccinology and Machine Learning역백신학 및 기계 학습을 사용한 COVID-19 코로나바이러스 백신 설계Immunology Published on 2020-07-032022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 비임상, [키워드] adhesins Analysis antigenicity applied breath Candidates caused clinical trial complementary Complete conserved contagious contagious disease coronavirus coronavirus vaccine COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccine development develop disease effective Epitopes FIVE Host human coronavirus immune responses induce infecting Invasion lack linear B-cell epitope linear B-cell epitopes machine learning membrane MERS MERS-CoV MHC-I MHC-II mild symptoms N protein non-structural protein non-structural protein 3 non-structural proteins NSP Nsp3 NSP8 nucleocapsid predict predicted Protective Protein Proteins proteome reverse vaccinology S protein Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus sequence stimulate structural protein T-cell epitopes target tested the S protein the SARS-CoV-2 Vaccine vaccine candidate Vaccine development vaxign vaxign-ML Viral virus was selected [DOI] 10.3389/fimmu.2020.01581 PMC 바로가기 [Article Type] Immunology
Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaquesReport Published on 2020-07-022022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome caused cellular immunity changes characterized clinical manifestation coronavirus Coronavirus disease 2019 COVID-19 detectable dissemination early recovery gastrointestinal tracts global pandemic histopathological humoral immune responses Infection initial interstitial pneumonia neutralizing antibody Patient Primary infection PROTECT Reinfection rhesus rhesus macaque rhesus macaques risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain subsequent viral disease [DOI] 10.1126/science.abc5343 PMC 바로가기 [Article Type] Report
Dendrigraft poly-L-lysines delivery of DNA vaccine effectively enhances the immunogenic responses against H9N2 avian influenza virus infection in chickensArticle Published on 2020-07-012023-06-22 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] 조류인플루엔자, [키워드] Delivery of DNA vaccine Dendrigraft poly-L-lysine H9N2 avian influenza immune responses Nanoparticles [DOI] 10.1016/j.nano.2020.102209
The long‐standing history of Corynebacterium parvum , immunity, and virusesReviews Published on 2020-06-292024-09-04 Journal: Journal of medical virology [Category] 대상포진, [키워드] C. parvum coronavirus immune responses immunomodulation Innate immunity [DOI] 10.1002/jmv.26100 PMC 바로가기 [Article Type] Reviews
A complex COVID-19 case with rheumatoid arthritis treated with tocilizumabCase Based Review Published on 2020-06-192022-10-31 Journal: Clinical Rheumatology [Category] COVID-19, SARS, [키워드] administration applied Aspergillus fumigatus close monitoring complex Coronavirus disease 2019 COVID-19 COVID-19 case CRS cytokine cytokine release storm disciplinary disease drug glucocorticoid Hydroxychloroquine IL-6 immune responses Immunity leflunomide long-term treatment opportunistic infection Patient patients patients with COVID-19 receptor signaling recurrence rheumatoid arthritis Secondary opportunistic infection Sequencing supplementary material Tocilizumab treated Treatment [DOI] 10.1007/s10067-020-05234-w PMC 바로가기 [Article Type] Case Based Review
SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vapingReview Published on 2020-06-102022-10-29 Journal: Journal of Inflammation (London, England) [Category] COVID-19, [키워드] ACE2 Activation age angiotensin-converting enzyme 2 caused condition COVID-19 COVID-19 infection COVID-19 patients COVID-19 susceptibility Cytokine storm develop diabetes disease E-cigarettes effective therapy engulfment epithelial permeability Future globe GM-CSF high affinity hypertension IFN-γ IL-2 IL-6 IL-7 immune responses Inflammation inflammatory storm IP-10 lung lung epithelium MCP-3 membrane morbidity and mortality Mortality outcome pandemic of COVID-19 pro-inflammatory Proteases provide receptor Research response S1 domain SARS-CoV-2 SARS-CoV2 SARS-CoV2 infection severe disease shown smoking target the SARS-CoV-2 therapy TMPRSS2 protease TNF-α vaping viral entry [DOI] 10.1186/s12950-020-00250-8 PMC 바로가기 [Article Type] Review
Immunologic aspects of characteristics, diagnosis, and treatment of coronavirus disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)의 특성, 진단 및 치료의 면역학적 측면Review Published on 2020-06-042022-08-13 Journal: Journal of Biomedical Science [Category] Biochemistry, COVID-19, SARS, [키워드] advancement antibodies Antibody-dependent enhancement approach approaches caused Characteristics component components coronavirus coronavirus disease COVID-19 cytokine Cytokine storm Defense develop Diagnosis Diagnostic method diagnostic methods Diseases evade facilitate Health Organization Host Host immune response host immune responses host immune system immune attack immune response immune responses immune system Immunologic Infection Infectious disease Infectious diseases Inflammatory response Innate immunity knowledge Like Lungs mechanism new strain new strain of coronavirus other infectious diseases pandemic proliferate SARS-CoV SARS-CoV-2 SARS-COV-2 infection Spread susceptible individuals the disease therapeutic agents Therapeutic strategies Treatment vaccination virus viruses World Health Organization [DOI] 10.1186/s12929-020-00663-w PMC 바로가기 [Article Type] Review
Why does COVID-19 disproportionately affect older people?Review Published on 2020-05-312022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress Affect age aging cardiovascular disease Coagulopathy consolidation coronavirus disease cough COVID-19 COVID-19 patient Cytokine release syndrome Cytokine storm death diabete Dyspnea Endotheliitis epigenetic clock explain fatal disease Fever genetic test greater Hospitalization identify immune responses Immunity independent risk factor individual Infection inhibiting life-threatening lung mechanism mechanisms mild illness molecular multiple organ failure obesity Older outcome regulate risk risk of death severity survival syndrome the disease Treatment virus [DOI] 10.18632/aging.103344 PMC 바로가기 [Article Type] Review
Cannabinoid Receptor Type 2: A Possible Target in SARS-CoV-2 (CoV-19) Infection?Review Published on 2020-05-272022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] Anti-inflammatory cannabinoid cannabinoid receptor type 2 cause cells circulating COVID-19 COVID-19 pandemic Cytokine storm death endocannabinoids system ENhance Estrogen Estrogens exacerbated excessive inflammation global pandemic immune cells immune response immune responses Inflammation Inflammatory limit Lung fibrosis Macrophage macrophage phenotype Mild modulating molecular target Novel coronavirus Patient Prevalence pro-inflammatory pro-inflammatory cytokines protective role receptor respiratory tract SARS-CoV-2 SARS-COV-2 infection small vessel susceptibility target Therapeutic strategies therapeutic target thrombosis Type women Wuhan, China [DOI] 10.3390/ijms21113809 PMC 바로가기 [Article Type] Review