Rapid and inexpensive whole-genome sequencing of SARS-CoV-2 using 1200 bp tiled amplicons and Oxford Nanopore Rapid BarcodingMethods Manuscript Published on 2020-07-182022-10-27 Journal: Biology Methods & Protocols [Category] COVID-19, [키워드] acute respiratory syndrome Amplicon barcode cause coronavirus coronavirus disease Coverage Critical faster FIVE Genome genome sequence less Nanopore Oxford Patient primer primer sets problem Rapid reduce RNA SARS-CoV-2 SARS-CoV-2 genome sequencing sequence unlikely variant Variation Viral transmission virus whole-genome sequencing [DOI] 10.1093/biomethods/bpaa014 PMC 바로가기 [Article Type] Methods Manuscript
Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19Article Published on 2020-07-182022-11-01 Journal: The New England Journal of Medicine [Category] COVID-19, MERS, SARS, 신종인플루엔자, [키워드] acute respiratory distress Analysis Angiogenesis ARDS Autopsy cell membranes changes in clinical implication coronavirus disease death died Diffuse alveolar damage endothelial injury examined Features Gene Expression growth histologic Infection infiltration Influenza Influenza virus Intussusceptive angiogenesis lung Lungs mechanism Microscopy microthrombi molecular observation pandemic pathophysiology Patient patients with influenza perivascular prevalent Progressive pulmonary Research Respiratory failure syndrome T-cell the disease thrombosis to define uninfected control Vascular vessel virus widespread [DOI] 10.1056/NEJMoa2015432 PMC 바로가기 [Article Type] Article
Genetic Polymorphisms Complicate COVID-19 Therapy: Pivotal Role of HO-1 in Cytokine StormReview Published on 2020-07-182022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] ACE ACE-2 ACE-2R acute respiratory distress Affect Angiotensin converting enzyme-2 Antiviral baseline bind cause Cell chronic inflammatory disease common cold coronavirus COVID-19 current CYP2D6 cytochrome P450 cytokine level Cytokine storm Cytokines disease Ebola Enzymes Genetic polymorphism genetic polymorphisms global pandemic HIV HO-1 Human immunodeficiency virus include Inflammatory response kidney Lungs majority manifested medication MERS Middle East mitochondrial dysfunction organ P450 patients with obesity porphyrins reactive oxygen specy receptor reservoir resulting RNA virus role SARS-CoV-2 Spread storm subsequent syndrome systemic inflammatory response therapy Treatment upregulation virus white adipose tissue [DOI] 10.3390/antiox9070636 PMC 바로가기 [Article Type] Review
Neonate Born to a Mother with a Diagnosis of Suspected Intra-Amniotic Infection versus COVID-19 or BothCase Report Published on 2020-07-182022-10-31 Journal: Case Reports in Pediatrics [Category] COVID-19, [키워드] anorexia caused clinical criteria Clinical diagnosis clinical risk factor Coronavirus disease 2019 cough Course COVID-19 Diagnosis fatigue fetal Fever greater healthcare providers Infection Leukocytosis mother myalgia Neonate Newborn Patient positive Prevent SARS-CoV-2 Shortness of breath sputum production Suspected Symptom Tachycardia the disease threshold Transmission virus [DOI] 10.1155/2020/8886800 PMC 바로가기 [Article Type] Case Report
Natural Polymorphisms Are Present in the Furin Cleavage Site of the SARS-CoV-2 Spike GlycoproteinSARS-CoV-2 스파이크 당단백질의 푸린 절단 부위에 천연 다형성이 존재합니다Genetics Published on 2020-07-172022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] Affect Candidates codon coronavirus COVID-19 DNA furin furin cleavage site host cells human cell human cells in vivo live-attenuated vaccine mutant Mutation mutations natural Non-synonymous premature stop codon present reduced required S protein SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 genome sequences Site spike spike glycoprotein strain the SARS-CoV-2 Transmissibility unique virus [DOI] 10.3389/fgene.2020.00783 PMC 바로가기 [Article Type] Genetics
An infant with coronavirus disease 2019 in China A case report4900 Published on 2020-07-172022-10-30 Journal: Medicine [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Adults Asymptomatic COVID-19 Atypical atypical symptom Case report China close contact Community confirmed cases coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diagnosed discharged early diagnosis epidemiological Infant Infection initial interferon Isolation less male Mild mother occurred oropharyngeal swab outbreak Patient patients of COVID-19 positive Reverse transcription-polymerase chain reaction severe acute respiratory syndrome coronavirus 2 Symptom tested the patient therapeutic therapy Transmission Treatment virus was tested Wuhan, China [DOI] 10.1097/MD.0000000000021359 PMC 바로가기 [Article Type] 4900
Genetic Diversity Among SARS-CoV2 Strains in South America may Impact Performance of Molecular DetectionArticle Published on 2020-07-172022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Affect annealing binding binding site Brazil China conserved coronavirus 2 database death detection Diversity E-gene Ecuador gene E gene N gene RdRp Impact in silico analysis individual infecting Molecular diagnosis nucleotide PCR performance primer-probe set RdRp gene reported respiratory Result SARS-CoV-2 SARS-CoV-2 genome SARS-CoV2 sensitivity South South America Spread strain Variation virus whole genome sequence Wuhan [DOI] 10.3390/pathogens9070580 PMC 바로가기 [Article Type] Article
Introductions and early spread of SARS-CoV-2 in the New York City area뉴욕시 지역에서 SARS-CoV-2의 도입 및 초기 확산Report Published on 2020-07-172022-08-13 Journal: Science (New York, N.y.) [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis assistance Care cause caused China city Cluster community transmission coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case epicenter Europe event Evidence exceeded focus identify independent indicate Infection introduced marker Mount Sinai Mount Sinai Health System New York City occurred pandemic Patient Phylogenetic analysis related virus related viruses reported respiratory SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes Science seeking sequence sequenced severe acute respiratory syndrome Coronavirus Spread spring suggested System The United States Transmission United States virus viruses [DOI] 10.1126/science.abc1917 PMC 바로가기 [Article Type] Report
Association of Search Query Interest in Gastrointestinal Symptoms With COVID-19 Diagnosis in the United States: Infodemiology StudyShort Paper Published on 2020-07-172022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, [키워드] abdominal pain Active disease Analysis analyzed approach baseline Care center Confirmed confirmed cases constipation correlation cough COVID-19 COVID-19 case COVID-19 pandemic cumulative Daily declining determine diarrhea disease Engineering Fever Gastrointestinal Gastrointestinal symptom Google Google Trends health information Hospitalization identify increases in individual Infectious disease interest internet search queries Johns Hopkins University Mild symptom moving average nausea negative control normalized notable objective offer Outbreaks pandemic Pandemics Patient population level positive control positive controls remained reported Repository Respiratory illness Result Science selected significantly Spread Symptom Symptoms System the disease The United States Transmission trend virus Volume vomiting was used were used while [DOI] 10.2196/19354 PMC 바로가기 [Article Type] Short Paper
Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoproteinArticle Published on 2020-07-172022-10-04 Journal: Nature Communications [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Analysis Antigen caused Cell conserved contribute coronavirus Coronaviruses Cryo-electron microscopy cryo-EM structure Cryoelectron microscopy form glycoprotein Health Hepatitis highly pathogenic Host information linker mechanism membrane membrane fusion MERS-CoV MHV motif mouse Protein Proteins receptor respiratory syndrome coronavirus responsible S2 subunit SARS virus SARS-CoV SARS-CoV S SARS-CoV-2 SARS-like coronaviruses significantly spike glycoprotein Structure target therapeutic therapy trimer upstream Vaccine viral entry viral membrane virus [DOI] 10.1038/s41467-020-17371-6 PMC 바로가기 [Article Type] Article