Factors associated with probable cluster of Leptospirosis among kennel workers in Abuja, NigeriaResearch Published on 2013-12-192023-05-31 Journal: The Pan African Medical Journal [Category] Fulltext, 조류인플루엔자, [키워드] dog Infection kennel leptospirosis Nigeria risk sewage Workers wounds zoonosis [DOI] 10.11604/pamj.2013.16.144.3529 PMC 바로가기 [Article Type] Research
Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum LevelsAlpha1-항트립신 혈청 수준이 있는 SERPINA 유전자 클러스터의 변이체의 인과적 및 합성적 연관성Research Article Published on 2013-08-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accelerated allele Alpha1-antitrypsin Analysis antitrypsin association Author Blood Causal chromosomal locus chronic obstructive chronic obstructive pulmonary disease circulating city Cohort common variants complex Concentration contribute COPD deficiency defined Degradation determined driven by Effect emphysema enzyme examined example explained functional gene cluster General population Genetic genetic determinant genetic determinants Genetic polymorphism genetic polymorphisms Genetic variant Genome-wide association study genome-wide significance genotyped genotyping GWAS Health heart hidden independent individual inhibitor Level locus Lung function MAF MAFs Meta-analysis minor allele frequency nucleotide obstructive pulmonary disease participant phenotype PI polymorphism PROTECT Protein pulmonary disease pulmonary tissue reached reduce replicated Replication respiratory risk risk factor SERPINA1 SERPINA1 gene Serum level serum levels Single nucleotide polymorphism single nucleotide polymorphisms Smokers SNP SNPs subsequent suggested Support synthetic tissue transfer Variability variant variants while [DOI] 10.1371/journal.pgen.1003585 PMC 바로가기 [Article Type] Research Article
Relevance of Rift Valley fever to public health in the European UnionReview Published on 2013-08-012023-06-02 Journal: Clinical microbiology and infection : the official [Category] 조류인플루엔자, [키워드] Europe public health Rift Valley fever risk Surveillance Trade [DOI] 10.1111/1469-0691.12163 [Article Type] Review
Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations세 아프리카 인구에서 심각한 말라리아의 대치 기반 메타 분석Research Article Published on 2013-05-232022-09-12 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] Affect affected African allele alleles Analysis approach association assumption Author Bayesian approach Bayesian approaches Blood blood type cause Cell children Community complex conducted confounding effect Control country detect different disease DNA variant ethnic group Ethnic groups Europe European feasibility fixed genes ABO genetic diversity genetic risk factor genetic risk factors genetics Genome-wide association studies Genome-wide association study genome-wide data genomic location genotype imputation GWAS Haemoglobin Haplotype HBB healthy individual heterogeneity heterogeneous individual Kenya kill location malaria malaria susceptibility loci Meta-analysis multicentre observation Population populations risk S allele Sample size sample sizes severe severe malaria sickle cell Sickle cell disease sickle cell disease) statistical model statistical test Statistical tests strength [DOI] 10.1371/journal.pgen.1003509 PMC 바로가기 [Article Type] Research Article
Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway류마티스 관절염의 인간 유전학은 CD40 신호 전달 경로의 고처리량 약물 검사를 안내합니다Research Article Published on 2013-05-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated After allele Analysis approved drug Arthritis association Author B cells B lymphocyte B lymphocytes Biology can be used CD19+ CD40 CD40 ligand CD40 signaling Cell cell line chemical compounds clinical care coding Combination complex Compound consequence controls correlation counter deep sequencing develop disease drug Drug discovery drugs effort eQTL ExoN exonic explain expression finding Follow-up gain-of-function Genetic genetic findings Genome-wide association studies Genome-wide association study genotyping guide GWAS healthy control homozygous Human Human genetics identify implicated increase individuals Infection Inflammation inhibit inhibitor loci locus lymphocyte Lymphocytes mononuclear cell mononuclear cells mouse NF-kB NF-κB NF-κB signaling non-risk allele observé p65 pathway Patient Peripheral blood Peripheral blood mononuclear cells Phosphorylation Protein Quantitative RA RELA reporter retroviral Rheumatoid rheumatoid arthritis risk risk allele Screen second Sequencing seropositive Signaling single SNP small molecule Small molecules small-molecule screen subject subunit therapy trait traits transcription factor treat variant while [DOI] 10.1371/journal.pgen.1003487 PMC 바로가기 [Article Type] Research Article
Surgery and risk for multiple sclerosis: a systematic review and meta-analysis of case–control studiesResearch Article Published on 2013-05-062024-09-02 Journal: BMC Neurology [Category] 대상포진, [키워드] adenoidectomy Appendectomy multiple sclerosis observational studies risk surgery systematic review tonsillectomy [DOI] 10.1186/1471-2377-13-41 PMC 바로가기 [Article Type] Research Article
Herpes Zoster and Subsequent Risk of Cancer: A Population-Based Study대상 인구 기반 연구를 통한 대상포진 및 이후 암 발생 위험Original Article Published on 2013-05-052023-05-31 Journal: Journal of Epidemiology [Category] Fulltext, 대상포진, 두창, 수두, 홍역, [키워드] Cancer cohort study herpes zoster incidence risk [DOI] 10.2188/jea.JE20120155 PMC 바로가기 [Article Type] Original Article
Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases기능성 IL6R 358Ala 대립유전자는 전통적인 IL-6 수용체 신호 전달을 손상시키고 다양한 염증성 질환의 위험에 영향을 미칩니다Research Article Published on 2013-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 358Ala Abdominal aortic aneurysm affecting allele analyzed aortic aneurysm approach Arthritis Asp358Ala association Asthma Atrial fibrillation Author balance benefit Cambridge BioResource causal variant CD4+ T cell CD4+ T cells CHD Chronic diseases circulating cleavage clinical trial clinical trials common diseases complex complex diseases Concentration Control copy Coronary heart disease Critical cytokine diabete diabetes etiology Evidence expression functional Genetic genetic association Genetic variation heart disease human disease identify IL-6 IL-6 receptor IL-6 signaling IL-6R IL-6R signaling IL-6R signaling pathway IL6R Immune cell immune cells impairment implicated implication increase increase in independent Inflammatory Inflammatory responses influence interleukin interleukin-6 isoform mechanism membrane-bound molecular mechanism monocyte Monocytes mononuclear cell mononuclear cells Non-synonymous nucleotide Patient PBMCs Peripheral blood Peripheral blood mononuclear cells Phosphorylation polymorphism Population protein level protein levels RA reduce reduced reduction regulated Regulation rheumatoid arthritis risk rs2228145 Signaling sIL-6R single nucleotide Single nucleotide polymorphism soluble IL-6R Stat1 STAT3 Stimulation suggested surface expression surface receptor susceptibility T cells T1D therapeutic intervention therapy These data Transcription transcription factor transcription factors translate Treatment response Type 1 diabetes variant Variation Volunteer [DOI] 10.1371/journal.pgen.1003444 PMC 바로가기 [Article Type] Research Article
Risk Factors for Influenza among Health Care Workers during 2009 Pandemic, Toronto, Ontario, CanadaArticle Published on 2013-04-012023-06-08 Journal: Emerging Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] aerosol Canada hand hygiene Health care worker Influenza pandemic respiratory risk Transmission Ventilation virus viruses [DOI] 10.3201/eid1904.111812 PMC 바로가기
Molecular Networks of Human Muscle Adaptation to Exercise and Age운동과 나이에 대한 인간 근육 적응의 분자 네트워크Research Article Published on 2013-03-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 13q21 1q12 activated all-trans-retinoic acid Activation adaptation age Ageing all-trans-retinoic acid alteration Analysis applicability aryl-hydrocarbon receptor signaling ATRA Author chance chromosomal Cohort cohorts component Compound continuum contributed developmental processe developmental processes Differential analysis displaying DNA topoisomerase down-regulation driven by EET endurance exercise endurance exercise training Epigenetic events exercise exhibited found Gain Gene gene-expression gene-networks gene-set gene-sets generate Genes growth Health care Health care system health care systems Human hypertrophic response hypertrophic responses hypertrophy identify Impact independent individual individuals Ingenuity Pathway Analysis inhibited Interaction IPA lean mass life loci Longevity mimicking molecular molecular network molecular networks mTOR muscle muscle age muscle growth Musculoskeletal network Older overlap pathway phenotype physical activity post-transcriptional processe post-transcriptional processes profile proportion Quality of life Rapamycin reduced referred to regulated related resistance-exercise training RET retinoic acid ribosomal genes rising risk RNA signature RNA signatures rRNAs RXR sarcopenia sarcopenic Serotonin Signaling significantly Society stream subject topoisomerase transcript unique Z-score [DOI] 10.1371/journal.pgen.1003389 PMC 바로가기 [Article Type] Research Article