The Potential Effect of Novel Coronavirus SARS-CoV-2 on NK Cells; A Perspective on Potential Therapeutic InterventionsImmunology Published on 2020-07-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] animal model COVID-19 disease Effect effective effector functional immune Immune cell inactivation infected cells kill morbidity morbidity and mortality Mortality NK cell NK cells novel Potential reported SARS-CoV-2 SARS-CoV-2 infected individual the disease therapeutic intervention virus while [DOI] 10.3389/fimmu.2020.01692 PMC 바로가기 [Article Type] Immunology
COVID-19 pandemic and psychological fatigue in TurkeyOriginal Articles Published on 2020-07-102022-10-30 Journal: The International Journal of Social Psychiatry [Category] COVID-19, [키워드] Affect age antibody treatment assessment association Attitude conducted COVID-19 COVID-19 pandemic COVID-19 virus cross-sectional Epidemic fatigue fatigued females Gender Health indicated individual Infectious disease information Isolation İstanbul KAP KAP study knowledge male mental health mental health professional multivariate organ Other outbreak overcome pandemic participant perceptions physical distance positive attitude Practice preventive measure provide Psychological psychologically public health Questionnaires reduce respiratory droplet Satisfaction scale sensitive organ significant difference significantly spread of COVID-19 Stepwise regression analysis Symptom Symptoms through contact transmitted Treatment Turkey variable variables virus [DOI] 10.1177/0020764020941889 PMC 바로가기 [Article Type] Original Articles
Identification of SARS-CoV-2 Cell Entry Inhibitors by Drug Repurposing Using in silico Structure-Based Virtual Screening ApproachImmunology Published on 2020-07-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 receptor Acetate analyzed anti-inflammatory agents anti-SARS-CoV-2 antiviral drugs approach approved assist binding binding energy binding mode cellular contagious COVID-19 drug drug-repurposing effective Efficiency enzyme FDA host cell host cell receptor identification in silico in vivo inhibiting Lung inflammation molecular docking molecular interaction motif pandemic pathogenic receptor Receptor binding domain receptor binding site Receptor-binding domain repurposing RNA viruses S-protein S-RBD SARS-coronavirus SARS-CoV-2 Screening spike glycoprotein Spike protein Spread targets therapeutic target viral surface Virtual screening virus was used WHO World Health Organization [DOI] 10.3389/fimmu.2020.01664 PMC 바로가기 [Article Type] Immunology
Studying the trend of the novel coronavirus series in Mauritius and its implicationsResearch Article Published on 2020-07-102022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] Care Community conditions contribute country covariate COVID-19 COVID-19 case Effect environmental factor estimate Evolution Health health authorities help implication Mauritius measure Novel coronavirus pandemic parameter predict Research researcher Safe significant variables statistically significant tested time factor Treatment virus WHO World Health Organization zoonotic [DOI] 10.1371/journal.pone.0235730 PMC 바로가기 [Article Type] Research Article
Transmission Routes Analysis of SARS-CoV-2: A Systematic Review and Case ReportCell and Developmental Biology Published on 2020-07-102022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] Antiviral treatment asymptomatic patient asymptomatic patients carriers China Clinical data Clinical diagnosis Course COVID-19 COVID-19 patient Disease diagnosis Epidemic epidemiological eyes-oral transmission Gastrointestinal infection gastrointestinal tract Human Infection outbreak Patient positive pulmonary infections report reported review route SARS-CoV-2 Spread Stool Symptom the disease the patient Transmission transmission route Transmission routes transmitted Viral transmission virus [DOI] 10.3389/fcell.2020.00618 PMC 바로가기 [Article Type] Cell and Developmental Biology
nCOVID-19 Pandemic: From Molecular Pathogenesis to Potential Investigational TherapeuticsCell and Developmental Biology Published on 2020-07-102022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] acute respiratory syndrome Affect analyzed antiviral activity antiviral drug Clinical efficacy Combination coronavirus Corticosteroids COVID-19 eculizumab Efficacy environmental factor Epidemic evaluate exhibited Favipiravir genetic diversity Good Hydroxychloroquine immunomodulators inhibitor molecular monoclonal nCOVID-19 novel coronavirus disease Pathogenesis Patient patients polyclonal antibody Potential RdRP RdRp inhibitors Remdesivir RNA-dependent RNA polymerase SARS-CoV-2 temperature therapeutic option Therapeutics Transmission treat umifenovir virus widespread worldwide pandemic Wuhan, China [DOI] 10.3389/fcell.2020.00616 PMC 바로가기 [Article Type] Cell and Developmental Biology
Emerging phylogenetic structure of the SARS-CoV-2 pandemicRapid Communication Published on 2020-07-102022-10-28 Journal: Virus Evolution [Category] COVID-19, [키워드] accumulating approach cell entry Continuous COVID-19 Efficacy effort epidemiological Epidemiology Europe European event example Factors gene region genetic diversity globe growth humans increase in increasingly MONITOR more difficult Mutation occur pandemic phylodynamic phylodynamics Phylogenetic question responsible reveal SARS-CoV-2 SARS-CoV-2 lineage significantly Spread Structure Support the SARS-CoV-2 trajectory viral replication virus virus demography [DOI] 10.1093/ve/veaa082 PMC 바로가기 [Article Type] Rapid Communication
Immune Thrombocytopenia in a Very Elderly Patient With Covid-19Medicine Published on 2020-07-102022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome Autoimmune autoimmune disorder bleeding characterized CMV coronavirus Corticosteroid Corticosteroids COVID-19 determine EBV elderly HCV hepatitis C virus HIV Human immunodeficiency virus Immune thrombocytopenia Infection Intravenous immunoglobulin Novel coronavirus infection Patient Platelet reported SARS-COV-2 infection severe adverse events therapeutic strategy thrombocytopenia Trigger triggered very old age virus [DOI] 10.3389/fmed.2020.00404 PMC 바로가기 [Article Type] Medicine
SARS-CoV-2 Molecular Network StructurePhysiology Published on 2020-07-102022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] accessory protein analyzed connection eight host protein molecular basis network Network topology non-structural protein pharmacological Protein RNA virus SARS-CoV-2 SARS-COV-2 infection scale-free network scale-free topology shown statistical analysis structural protein Structure therapeutic targets Viral protein virus virus interactome [DOI] 10.3389/fphys.2020.00870 PMC 바로가기 [Article Type] Physiology
Recent Advancements in the Diagnosis, Prevention, and Prospective Drug Therapy of COVID-19Review Published on 2020-07-102022-10-04 Journal: Frontiers in Public Health [Category] MERS, 신약개발, [키워드] 2019-nCoV acute respiratory syndrome advancement approved approved drugs carried cause China clinical condition clinical trial clinical trials common cold confirmed case coronavirus CoV COVID-19 CoVs death Diagnosis diagnostic tests drug Drug repurposing Efficacy and safety Evidence global pandemic illness imperative in vitro International lack outbreak Outbreaks prevention Prospective public health emergency recent reduction in Respiratory illness SARS-CoV-2 severity Treatment treatment approach Vaccines virus WHO World Health Organization [DOI] 10.3389/fpubh.2020.00384 PMC 바로가기 [Article Type] Review