virus – Page 994 – Communicable Diseases Research

Cell-Mediated Immune Responses to COVID-19 Infection

Immunology

Published on 2020-07-032022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Noteworthy Neurological Manifestations Associated With COVID-19 Infection

Internal Medicine

Published on 2020-07-032022-10-31
Journal: Cureus [Category] COVID-19,

Identification of novel mutations in RNA-dependent RNA polymerases of SARS-CoV-2 and their implications on its protein structure

SARS-CoV-2의 RNA 의존성 RNA 중합효소의 새로운 돌연변이 식별 및 단백질 구조에 미치는 영향

Biochemistry

Published on 2020-07-032022-08-13
Journal: PeerJ [Category] Biochemistry, COVID-19,

[키워드] (RdRp Alter alteration Analysis antigenic antivirals COVID-19 pandemic develop drug resistance duplication effective evade functional consequence functional consequences Genome Health high mutation rate highlighting host immunity identification identify implication Indian geographical area interfere isolate Mutation mutation rate Nsp12 Occurrence pharmacological agents Protein RdRP RdRp mutation RdRp mutations RdRp protein RdRp sequence RdRp sequences RNA synthesis RNA virus RNA-dependent RNA polymerase RNA-dependent RNA polymerases (RdRp) SARS-CoV-2 SARS-CoV-2 isolate secondary structure secondary structure prediction analysis sequence Seven shifting stability the SARS-CoV-2 Variability Variation Viral viral evolution viral genome Viral RNA Viral RNA-dependent RNA polymerases virus viruses
[DOI] 10.7717/peerj.9492 PMC 바로가기 [Article Type] Biochemistry

While We Wait for a Vaccine Against SARS-CoV-2, Why Not Think About Available Drugs?

Physiology

Published on 2020-07-032022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

[키워드] ACE2 Against angiotensin-converting enzyme 2 approach atomic resolution blocked bronchoalveolar catastrophic Cell cells complex coronavirus coronavirus disease coronavirus spike protein COVID-19 Cryo-electron microscopy crystal structure design drugs develop Disease progression drug Effect effort entry routes epithelial etiological agent exhibit Health Host host cell receptor inhibiting inhibitor Interaction measure membrane-bound modulating pandemic pathway pharmacological Prophylaxis proportion protease receptor receptors SARS-CoV-2 target therapeutic approaches Trial upper respiratory tract Vaccine viral entry virus viruses while X-ray diffraction
[DOI] 10.3389/fphys.2020.00820 PMC 바로가기 [Article Type] Physiology

Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species

Veterinary Science

Published on 2020-07-032022-11-01
Journal: Frontiers in Veterinary Science [Category] COVID-19,

Comparison of two methods to clear the airways of critically ill children and adults with COVID-19 infection: a structured summary of a study protocol for a pilot randomized controlled trial

Letter

Published on 2020-07-032022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] age airway Alpha anticipated approved assistant benefit Blinding Care carried Chest Chest physiotherapy children Complication coordinating center COVID-19 Critically ill dissemination element expiratory File healthcare worker hypertonic Hypoxemia ICU ICUs independent intensive care intensive care unit intervention arm invasive ventilation management mechanical ventilation mechanically ventilated patient Mortality nasal nasal mask non-inferiority design Non-invasive non-invasive ventilation number objective Oscillation outcome Oxygenation pandemic participant patients with COVID-19 pediatric performed Physiotherapist pilot multicenter positive positive airway pressure Positive end-expiratory pressure positive pressure ventilation Pragmatic Primary outcome protocol provided random Randomized Randomized controlled trial Randomly recruited recruitment reduce Research responsible Sample size sealed Study protocol treatment for COVID-19 ventilator virus vital signs Volume vomiting website with COVID-19
[DOI] 10.1186/s13063-020-04533-6 PMC 바로가기 [Article Type] Letter

Community Drivers Affecting Adherence to WHO Guidelines Against COVID-19 Amongst Rural Ugandan Market Vendors

Public Health

Published on 2020-07-032022-10-31
Journal: Frontiers in Public Health [Category] COVID-19, MERS,

COVID-19 Coronavirus Vaccine Design Using Reverse Vaccinology and Machine Learning

역백신학 및 기계 학습을 사용한 COVID-19 코로나바이러스 백신 설계

Immunology

Published on 2020-07-032022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 비임상,

[키워드] adhesins Analysis antigenicity applied breath Candidates caused clinical trial complementary Complete conserved contagious contagious disease coronavirus coronavirus vaccine COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccine development develop disease effective Epitopes FIVE Host human coronavirus immune responses induce infecting Invasion lack linear B-cell epitope linear B-cell epitopes machine learning membrane MERS MERS-CoV MHC-I MHC-II mild symptoms N protein non-structural protein non-structural protein 3 non-structural proteins NSP Nsp3 NSP8 nucleocapsid predict predicted Protective Protein Proteins proteome reverse vaccinology S protein Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus sequence stimulate structural protein T-cell epitopes target tested the S protein the SARS-CoV-2 Vaccine vaccine candidate Vaccine development vaxign vaxign-ML Viral virus was selected
[DOI] 10.3389/fimmu.2020.01581 PMC 바로가기 [Article Type] Immunology

Lions, tigers and kittens too: ACE2 and susceptibility to COVID-19

Brevia

Published on 2020-07-032022-11-01
Journal: Evolution, Medicine, and Public Health [Category] COVID-19,

Current Findings Regarding Natural Components With Potential Anti-2019-nCoV Activity

Cell and Developmental Biology

Published on 2020-07-032022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] 2019-nCoV 2019-nCoV infection 3CL pro ACE2 activity addition approach candidate cause cellular receptor China Chinese component Compound contribute coronavirus COVID-19 current disease drug Effects element enzyme Evidence feasibility finding functional mechanisms functions Helicase inhibit M pro main mechanism Measures natural natural products Novel coronavirus pandemic plant compounds Pneumonia Potential Precaution preventing infection provided recent S protein Spread structural feature structural protein targeting therapeutic agent Therapeutic strategies Vaccine virus WHO World Health Organization
[DOI] 10.3389/fcell.2020.00589 PMC 바로가기 [Article Type] Cell and Developmental Biology