2B11 – Communicable Diseases Research

Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries

Article

Published on 2021-07-272022-10-04
Journal: Cell Discovery [Category] 변종,

[키워드] 2B11 ACE2-binding site acute respiratory syndrome antibodies antibody B.1.1.7 B.1.1.7 variant B.1.351 Combination complexes convalescent coronavirus COVID-19 convalescent patients effective intervention Efficacy Efficiency eight epitope Epitopes exhibited experiment Genes heavy chain highest affinity IGHV immune Immunoglobulin immunology in vivo mice NAb neutralization neutralization potency Neutralizing neutralizing antibody overlap P.1 PBMC Prophylactic pseudoviruses public health RBD SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2 virus SARS-CoV-2-neutralizing antibody Screening structural biology the receptor-binding domain the S1 protein therapeutic Treatment variant viruses wild-type WT SARS-CoV-2
[DOI] 10.1038/s41421-021-00295-w PMC 바로가기 [Article Type] Article

Neutralizing antibodies against porcine epidemic diarrhea virus block virus attachment and internalization

Research

Published on 2018-08-302022-10-28
Journal: Virology Journal [Category] Coronavirus,

[키워드] 2B11 antibody attachment B cell binding blocked cause Cell conformational defined epidemic diarrhea epitope expression generate host cell receptor identify Infection inhibit inhibited Isolating mAb mechanism monoclonal antibody neutralized neutralizing antibody pathogenic coronavirus PEDV Porcine epidemic diarrhea virus prokaryotic expression system qPCR receptor-binding domains Result S protein secrete specific antibodies suggested supplementary material Surface glycoprotein target protein the receptor-binding domain Vero cells Vero E6 cell viral spike virions virus virus entry virus infection was performed was used were used
[DOI] 10.1186/s12985-018-1042-3 PMC 바로가기 [Article Type] Research

Molecular characterization of a single-chain antibody variable fragment (scFv) specific for PspA from Streptococcus pneumoniae

스트렙토코쿠스 폐렴구균(PspA) 특이적인 단일 사슬 항체 변이 조각(scFv)의 분자적 특성 분석

Article

Published on 2017-01-012024-08-24
Journal: Biochemical and Biophysical Research Communications [Category] 폐렴구균 감염증,

[키워드] 2B11 epitope phage display PspA Single-chain antibody variable fragment Streptococcus pneumoniae