Folylpolyglutamate synthetase mRNA G-quadruplexes regulate its cell protrusion localization and enhance a cancer cell invasive phenotype upon folate repletionarticle Published on 2023-02-012024-09-05 Journal: BMC Biology [Category] update2024, [키워드] 3′UTR Cell protrusions Folic acid Folylpolyglutamate synthetase G-quadruplex Invasion RNA transport [DOI] 10.1186/s12915-023-01525-1 PMC 바로가기 [Article Type] article
HLA-G 14-bp insertion/deletion polymorphism and risk of coronavirus disease 2019 (COVID-19) among Iraqi patients이라크 환자의 HLA-G 14bp 삽입/삭제 다형성 및 코로나바이러스 질병 2019(COVID-19)의 위험Article Published on 2022-06-012022-09-11 Journal: Human immunology [Category] 변종, [키워드] 14-bp insertion/deletion polymorphism 3′UTR 95% confidence interval allele Antigen case-control study conducted Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical disease Del disease severity Frequency Gender Genotype genotypes higher risk HLA-G Human human leukocyte antigen insertion insertion/deletion leukocyte median no significant difference no significant differences Odds ratio Patient patients with COVID-19 patients with moderate polymorphism Probability Result risk risk of COVID-19 SARS-CoV-2 serum significantly significantly higher stratified suggested susceptibility up-regulated with COVID-19 [DOI] 10.1016/j.humimm.2022.03.005 PMC 바로가기 [Article Type] Article
Sequence analysis for SNP detection and phylogenetic reconstruction of SARS-cov-2 isolated from Nigerian COVID-19 casesResearch article Published on 2022-01-012022-10-05 Journal: New Microbes and New Infections [Category] 변종, 유전자 메커니즘, 치료기술, [키워드] 2019-nCoV 3′UTR accounted addition Analysis average base causative pathogen characteristic characterized clade Clustering community transmission conserved Coronaviridae COVID-19 COVID-19 case Culture D614G D614G mutation disease distribution family Frequency GenBank genome sequence Genome sequence data genomic genomic region genus Betacoronavirus GISAID GISAID database highest include index case Intensive likelihood Lineage MAFFT morbidity and mortality Multiple mutants New coronavirus Nigeria Novel coronavirus ORF10 ORF1ab pandemic Phylogenetic Phylogenetic tree Phylogeny reference genome Region regions Result retrieved SARS-CoV-2 SARS-CoV-2 genome sequence severe respiratory symptom significantly higher similarity SNP SNPs spike gene Treatment Version viral sequences virus was done were used widespread [DOI] 10.1016/j.nmni.2022.100955 [Article Type] Research article
A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection바이러스 유래 마이크로 RNA는 SARS-CoV-2 감염 시 면역 반응 유전자를 표적으로 한다Article Published on 2021-12-162022-09-10 Journal: EMBO Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] 3′UTR Argonaute conserved COVID‐19 COVID‐19 patients COVID‐19 cultured cells Dicer enzyme evade expression help Host Host immune response host immune responses host miRNA human cell identify immune response immune response gene immune response genes immune responses infected cell infected cells innate immune response interfere interferon interferon response isoform Microbiology, Virology & Host Pathogen Interaction microRNA miRNA miRNAs Nasopharyngeal swab nasopharyngeal swabs Patient predominant Proteins repress represse RNA Biology SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected SARS‐CoV‐2 sequence small RNA Small RNAs target transcript Viral viral genome viral miRNA [DOI] 10.15252/embr.202154341 PMC 바로가기 [Article Type] Article
Comparative Characterization and Pathogenicity of a Novel Porcine Epidemic Diarrhea Virus (PEDV) with a Naturally Occurring Truncated ORF3 Gene Coinfected with PEDVs Possessing an Intact ORF3 Gene in PigletsArticle Published on 2021-08-072022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] 3′UTR caused characterization China Clinical sign Coinfection Comparative Complete demonstrated diarrhea disease enterocytes epidemic diarrhea exhibited genetic marker Genotype genotypes highest hpi identity inoculated Intact molecular characteristics mortality rate Naturally novel nucleotide ORF3 pathogenicity PEDV Porcine epidemic diarrhea virus Region reported significantly higher strain Vaccine development virulence virus were infected [DOI] 10.3390/v13081562 PMC 바로가기 [Article Type] Article
miR-129a-3p Inhibits PEDV Replication by Targeting the EDA-Mediated NF-κB Pathway in IPEC-J2 CellsArticle Published on 2021-07-292022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] EDA 3′UTR activate activating Activation binding CARD11 caspase Cell cells cytopathic domain downregulated downstream EDA epidemic diarrhea expression expression level Gene Expression Infection inhibit inhibited inhibiting Ligand mechanism microRNA miR-129a-3p miRNA miRNAs molecular mechanism NF-κB NF-κB pathway pathological changes PEDV PIGS previous study promote promoted recruitment reduced regulate Regulatory Replication shown significantly targeting transcriptome sequencing upregulation viral infections viral replication virus was used [DOI] 10.3390/ijms22158133 PMC 바로가기 [Article Type] Article
The Heterogeneous Landscape and Early Evolution of Pathogen-Associated CpG Dinucleotides in SARS-CoV-2SARS-CoV-2에서 병원체 관련 CpG 디뉴클레오티드의 이질적 풍경과 초기 진화Discoveries Published on 2021-06-082022-09-10 Journal: Molecular Biology and Evolution [Category] SARS, 치료법, [키워드] 3′UTR acting acute respiratory syndrome Amino acid Antiviral antiviral protein binding pattern binding patterns circulating coding region comparable COVID-19 COVID-19 pandemic CpG CpG motifs cytoplasm dinucleotide dinucleotides distribution dual dysregulated Evolution evolution of synonymous mutations expressed Genome greater HKU1 human host immune infected cell infected cells landscape lead loci MERS motif Mutation ORF outbreak pathogen-associated molecular pathogen-associated molecular patterns pathogenic Pattern recognition pattern recognition receptor Pattern recognition receptors pressure Protein Region Replication respiratory RNA SARS-CoV-2 SARS-CoV-2 genome Sequence motifs Signaling signature ssRNA viruses statistical synonymous the SARS-CoV-2 genome transcript transversion triggering Viral viral host mimicry Zinc zinc finger antiviral protein [DOI] 10.1093/molbev/msab036 PMC 바로가기 [Article Type] Discoveries
In-Depth Bioinformatic Analyses of Nidovirales Including Human SARS-CoV-2, SARS-CoV, MERS-CoV Viruses Suggest Important Roles of Non-canonical Nucleic Acid Structures in Their LifecyclesMicrobiology Published on 2020-07-032022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 3′UTR acid binding Bioinformatic coronavirus determine evaluate Evidence G-quadruplex Genome genomic RNA genomic sequence Human human protein Including indicate inverted repeats loci mechanism MERS-CoV molecular motif mRNA Nidovirale notable nucleic acid nucleotides Regulation Regulatory RNA role SARS-CoV SARS-CoV-2 SARS-CoV-2 RNA sequenced Structure structures [DOI] 10.3389/fmicb.2020.01583 PMC 바로가기 [Article Type] Microbiology
Characterization and Pathogenicity of the Porcine Deltacoronavirus Isolated in Southwest ChinaArticle Published on 2019-11-182022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] 3′UTR amino acid changes Analysis Asia cause Cell Characteristics characterization characterized China Cytopathic effect death demonstrated diarrhea Epidemic Epidemiology Evolution gastrointestinal tract GenBank Genetic highly pathogenic identity immunofluorescence indicated Infection information insertion Isolated isolates Japan Microscopy molecular multiple organs Neonatal nine North America nucleotide mutation occurred ORF1ab gene passages pathogen pathogenicity Phylogenetic analysis Porcine deltacoronavirus ranged Recombination recombination event reported resulting S gene Sequencing analysis South Korea strain Strains TCID USA vomiting whole genome [DOI] 10.3390/v11111074 PMC 바로가기 [Article Type] Article
MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus ErythematosusMicroRNA-3148은 전신성 홍반성 루푸스와 관련된 톨 유사 수용체 7 변이체의 대립형질 발현을 조절합니다Research Article Published on 2013-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3′ UTR 3′UTR activate affecting African Americans allelic Americans Antigen Asian Asians association Author Autoimmune Autoimmune disease binding binding site C allele C-allele carriers conducted contributed Control copy number correlated debilitating autoimmune disease decrease Degradation dose-dependent downregulated driven by duplication elevated Epigenetic European Evidence exhibited exhibiting expression functional G allele G-allele genomic greater HEK-293 HEK-293 cell HEK-293 cells Human identify IFN IFN-α pathway increased risk independent individual innate immune activation lack led to luciferase luciferase activity Lupus lupus erythematosus lupus-like disease mechanism microRNA microRNA-3148 microRNA–gene miR-3148 modulation mononuclear cell mononuclear cells mRNA murine model non-risk allele non-risk C allele nuclear nucleotide Odds ratio overexpression Pathways PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells polymorphism predicted promote Protein protein level provide R 2 reduction regulate Regulatory reported reporter reporter gene respond resulting risk sequence signaling pathways significantly increased single nucleotide Single nucleotide polymorphism SLE SLE patient SLE patients SNP subject susceptibility systemic systemic lupus erythematosus the strongest These data TLR7 TLR7 gene TLR7 mRNA TLR7-TLR8 region TLR7/8/9 TLRs Toll-like receptor toll-like receptor 7 Toll-like receptors transcript transcript level transcripts transfected cells type I interferon UTR variant Variation while [DOI] 10.1371/journal.pgen.1003336 PMC 바로가기 [Article Type] Research Article