Effectiveness of population-wide screening and mass drug administration for leprosy control in Kiribati: the COMBINE protocolProtocol Published on 2023-06-292024-09-05 Journal: BMJ Open [Category] update2024, [키워드] ACF active case finding contacts Hansen’s disease Intervention Kiribati leprosy mass chemoprophylaxis Mass drug administration MDA Pacific PEP Population Post-exposure prophylaxis prevention Prophylaxis Rifapentine SDR Single-dose rifampicin universal leprosy prophylaxis [DOI] 10.1136/bmjopen-2022-065369 PMC 바로가기 [Article Type] Protocol
Acriflavine and proflavine hemisulfate as potential antivirals by targeting MproArticle Published on 2022-12-012022-11-15 Journal: Bioorganic chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] ACF acriflavine activity addition anti-SARS-CoV-2 Antiviral antiviral target BHK-21 cell Compound Coronaviruses demonstrated effective drugs effort enzymatic assay experiment HCoV-OC43 in vitro Infection inhibited inhibitor inhibitors inhibitory activity M pro M(pro) inhibitor MPro Proflavine Proflavine hemisulfate Remdesivir Replication reported SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 virus Transcription Viral RNA [DOI] 10.1016/j.bioorg.2022.106185 PMC 바로가기
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses임상적으로 승인된 약물인 Acriflavine은 SARS-CoV-2 및 기타 베타 코로나바이러스를 억제합니다.Article Published on 2022-05-192022-09-11 Journal: Cell chemical biology [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] ACF acriflavine approved Betacoronavirus betacoronaviruses binding block catalytic caused cellular clinical trial clinical trials clinically Concentration coronavirus COVID-19 COVID-19 pandemic drug Drug repurposing effective effort epithelia Ex vivo human airway human airway epithelia identify in some in vivo inhibit inhibitor limit mice Mortality NMR Outbreaks pandemic Papain-like protease PL(pro) protease Protease inhibitor Research SARS-CoV-2 severe disease structural biology tested Vaccines viral replication [DOI] 10.1016/j.chembiol.2021.11.006 PMC 바로가기 [Article Type] Article
Multi-Regional Modeling of Cumulative COVID-19 Cases Integrated with Environmental Forest Knowledge Estimation: A Deep Learning Ensemble ApproachArticle Published on 2022-01-102022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Accuracy ACF analyzed applied ARIMA artificial intelligence autocorrelation average COVID-19 COVID-19 case COVID-19 pandemic criteria criterion cumulative deep deep learning diagnostics ensemble ARIMA evaluate forest forest knowledge Hospitalization information knowledge learning likelihood memory modeling outcome predict prediction random were used while [DOI] 10.3390/ijerph19020738 PMC 바로가기 [Article Type] Article