Development of a PROTAC-Based Targeting Strategy Provides a Mechanistically Unique Mode of Anti-Cytomegalovirus Activity
Article
[키워드] activity
addition
Adenovirus
analyzed
Antiviral
antiviral activity
antiviral drugs
antiviral therapy
antivirals
applicability
approach
CDK1
CDK2
CDK7
CDK9
Chimera
Clinical symptoms
clinically
Combined
Concentration
current
Degradation
demonstrated
development
Direct-acting antivirals
Efficacy
elements
HCMV
help
host-directed antivirals
Human
Human Cytomegalovirus
human/animal pathogenic viruses
IMPROVE
indicated
inhibitor
investigated
kinase inhibitors
mode
murine
new drug qualities
pathogenic
prevalent
PROTAC-based targeting strategy
PROteolysis TArgeting Chimeras
required
SARS-CoV-2 replication
strain
Strategy
target
targeting
varicella
variety
virus
Zika virus
[DOI] 10.3390/ijms222312858 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/ijms222312858 PMC 바로가기 [Article Type] Article