Response to PEEP in COVID-19 ARDS patients with and without extracorporeal membrane oxygenation. A multicenter case-control computed tomography studyObservational Study Published on 2022-07-022022-10-04 Journal: Critical Care [Category] 임상, [키워드] adverse effect alveolar appear ARDS ARDS patients benefit Case-control case-control study Computed tomography conducted COVID-19 COVID-19 ARDS patient ECMO extracorporeal membrane oxygenation fraction greater logarithm lung lung collapse Lung recruitability median moderate multicenter not significantly different Patient patients PEEP PEEP. Pneumonia Recruitability recruitment required response severe ARDS severe COVID-19 patient significantly significantly higher significantly lower Total variations [DOI] 10.1186/s13054-022-04076-z PMC 바로가기 [Article Type] Observational Study
Association between early cumulative fluid balance and successful liberation from invasive ventilation in COVID-19 ARDS patients – insights from the PRoVENT-COVID study: a national, multicenter, observational cohort analysisObservational Study Published on 2022-06-012022-10-04 Journal: Critical Care [Category] 임상, [키워드] 95% CI acute respiratory distress adjusted adjusted hazard ratio Affect Analysis analyzed ARDS association Cohort cohort analysis COVID-19 COVID-19 ARDS patient COVID-19 patient COVID-19 patients Cox proportional hazard Critical care critically ill patients cumulative Cumulative fluid balance Date Evidence Fluid management group hospital Increasing indicate International invasive ventilation invasively ventilated patient lack Liberation of ventilation. median multicenter National Netherland outbreak Patient patients performed potential benefit Primary outcome Probability required severity significantly syndrome three group Ventilated Ventilation with COVID-19 [DOI] 10.1186/s13054-022-04023-y PMC 바로가기 [Article Type] Observational Study
Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate to severe ARDS in a randomized, placebo-controlled, double-blind trial: preliminary evaluation of safety and feasibility in light of the COVID-19 pandemicRandomized Controlled Trial Published on 2022-04-042022-10-05 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] activity Alter ARDS ARDS patient Ascending baseline causes Clinical characteristics clinical study clinical trial conducted COVID-19 COVID-19 ARDS patient COVID-19 pandemic COVID-19 patient doses double-blind DSMB edema Efficacy enrolled Enrollment Evidence exceptional feasibility groups indication interim analysis investigator less mandatory Multiple multiple ascending dose noradrenaline not differ observation period outcome Oxygenation pandemic parameter Patient patients with moderate permeability phase IIB placebo-controlled pulmonary Pulmonary edema pulmonary permeability Randomized required risk Safety Safety Monitoring Board SARS-CoV-2 Sepsis severe ARDS sick Solnatide Study design survival rate treat Trial Ventilation [DOI] 10.1186/s13063-022-06182-3 PMC 바로가기 [Article Type] Randomized Controlled Trial
Direct comparison of different therapeutic cell types susceptibility to inflammatory cytokines associated with COVID-19 acute lung injuryCOVID-19 급성 폐 손상과 관련된 염증성 사이토카인에 대한 다양한 치료 세포 유형 감수성의 직접 비교Research Published on 2022-01-152022-09-10 Journal: Stem Cell Research & Therapy [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome Alter Analysis ARDS ARDS patients Bone marrow Cell Cell therapy cell type cell viability cells characterized clinical evaluation clinical trial clinically Combination conditioned media COVID-19 COVID-19 ARDS patient cytokine Cytokine storm Cytokines Cytometry deleterious effect determine Direct Disease progression dose doses dysregulated immune response evaluate the effect excluded expression Extracellular Extracellular vesicles Flow flow cytometry greater high risk IL-6 immunomodulatory implicated Infection Inflammatory cytokine Inflammatory cytokines inflammatory mediator Inflammatory mediators mediators Mesenchymal stromal cells Mild Mortality not altered Novel coronavirus paracrine pathology Patient pro-inflammatory mediator pro-inflammatory mediators progression proteomic receptor receptors respiratory distress Respiratory distress syndrome Result severe ARDS severe COVID-19 stem cell stem cells stromal cells supplementary material survival susceptibility syndrome the cell therapeutic therapeutic efficacy therapy Treatment umbilical Vesicle viability were assessed widespread with COVID-19 [DOI] 10.1186/s13287-021-02699-7 PMC 바로가기 [Article Type] Research
Extracellular Vesicle Associated miRNAs Regulate Signaling Pathways Involved in COVID-19 Pneumonia and the Progression to Severe Acute Respiratory Corona Virus-2 Syndrome세포 외 소포 관련 miRNA는 COVID-19 폐렴에 관여하는 신호 전달 경로를 조절하고 심한 급성 호흡기 코로나 바이러스 -2 증후군으로의 진행Immunology Published on 2021-12-092022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] ACE2 expression activated adjusted alveolar cell among others Analysis analyzed ARDS ARDS patients bind Biomarker Biomarkers carrier carriers Cell cell-free microRNAs cell-to-cell communication cells circulating community acquired pneumonia controls Corona COVID-19 COVID-19 ARDS patient COVID-19 pneumonia CXCL8 Differential gene expression differential gene expression analysis differentially expressed miRNA downregulated epithelial evaluated EVs Extracellular vesicles function group healthy control healthy controls IL6 increase Inflammatory inhibited interleukin interleukin-6 interleukin-8 investigated let-7e-5p log2FC lung Lung diseases mechanically ventilated patient mediators miR-146 miR-146a-5p miRNA miRNAs mRNA mRNA transcript mRNA transcripts nasal epithelium network network analysis neutrophil neutrophil recruitment olfactory OR52N2 pathophysiology Pathways Pneumonia Precipitation prospectively studied receptor regulate regulated respiratory Result resulting RNA sequencing SARS-CoV-2 spike protein secrete Sepsis Severe Acute Respiratory Corona Virus-2 Syndrome severe COVID-19 Signaling signaling pathway significantly small RNA small RNA sequencing Spike protein symptomatic patient syndrome the healthy therapeutic targets TLR4 Toll-like receptor toll-like receptor 4 total RNA transcript upregulated Vesicle with COVID-19 [DOI] 10.3389/fimmu.2021.784028 PMC 바로가기 [Article Type] Immunology
Respiratory Pathophysiology of Mechanically Ventilated COVID-19 PatientsInternal Medicine Published on 2021-12-062022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome adult COVID-19 patient analyzed ARDS collected conducted Coronavirus disease 2019 COVID-19 COVID-19 ARDS patient COVID-19 patient disease driving electronic medical record IBM ICU intubation investigator IQR less lung mechanics management measurement mechanical ventilation mechanically ventilated median moderate Non-COVID-19 patients not differ PaO partial pressure of arterial oxygen/ fractional inspired oxygen pathogenesis of COVID-19 pathophysiology Patient peak inspiratory pressure PEEP Plateau pressure Positive end-expiratory pressure ranged respiratory respiratory pathophysiology Respiratory system retrospective cohort study Science severe acute respiratory syndrome coronavirus-2 severe ARDS static compliance statistical analysis syndrome the median [DOI] 10.7759/cureus.20218 PMC 바로가기 [Article Type] Internal Medicine
A radiological predictor for pneumomediastinum/pneumothorax in COVID-19 ARDS patientsObservational Study Published on 2021-12-012022-10-05 Journal: Journal of critical care [Category] SARS, 임상, [키워드] 95% confidence interval Accuracy acute respiratory distress acute respiratory distress syndrome ARDS baseline case-control study chest CT scan chest imaging COVID-19 COVID-19 ARDS patient COVID-19 ARDS patients database demonstrated determine distress enrolled False positives invasively ventilated patient linear material Mechanical mechanical ventilation Patient Pneumomediastinum Pneumothorax Positive predictive value predicts radiological radiological evidence sensitivity specificity subsequent syndrome Tomography, X-Ray Computed tracheal true positives Ventilated were excluded X-ray [DOI] 10.1016/j.jcrc.2021.07.022 PMC 바로가기 [Article Type] Observational Study
Impact of obesity on survival in COVID-19 ARDS patients receiving ECMO: results from an ambispective observational cohortResearch Published on 2021-11-152022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome affected age Analysis ARDS ARDS patient arterial pH BMI Cohort Compliance coronavirus COVID-19 COVID-19 ARDS patient ECMO Extra-corporeal membrane oxygenation Health care system ICU identify Impact independent interquartile range IQR mechanical ventilation median multivariate logistic regression obesity Observational cohort study outbreak PaO Patient PEEP presenting Prognosis receiving Respiratory system Result risk factor SARS-CoV-2 severe ARDS severe COVID-19 supplementary material supported survival survival rate syndrome university hospital Ventilated [DOI] 10.1186/s13613-021-00943-0 PMC 바로가기 [Article Type] Research
The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients인공호흡 비율의 진화는 기계적으로 환기되는 COVID-19 ARDS 환자의 예후 인자입니다Observational Study Published on 2021-09-132022-09-12 Journal: Critical Care [Category] 임상, 진단, [키워드] association Clinical data clinical evolution cohort study collected consecutive patient coronavirus COVID-19 COVID-19 ARDS patient creatinine death Evolution higher risk ICU ICU admission include increase in information Intubated intubation mechanical ventilation mechanically ventilated Mortality outcomes PaO Patient patients with COVID-19 Platelet Prognostic factor receiving remained required Result SARS-CoV-2 Spanish supplementary material variable Variation ventilatory Ventilatory ratio with COVID-19 [DOI] 10.1186/s13054-021-03727-x PMC 바로가기 [Article Type] Observational Study
Comprehensive investigation of RNA-sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndromeRNA 시퀀싱 데이터 세트에 대한 포괄적인 조사는 코로나바이러스 질병 2019 급성 호흡 곤란 증후군의 허브 유전자 및 분자 메커니즘을 보여줍니다Article Published on 2021-08-012022-09-11 Journal: IET systems biology [Category] 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome Analysis approach ARDS ARDS patients CD4 Cell complement Comprehensive comprehensive analysis control group coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 ARDS patient cytokine dataset DEGs differentially expressed gene Differentially expressed genes drug eosinophil eosinophils follicular Functional enrichment analysis G-protein Glutamate GSE163426 hub genes Immune cell infiltration infiltration involved Macrophage macrophages mechanism molecular mechanism molecular mechanisms network analysis pathway patients potential molecular receptor respiratory distress Respiratory distress syndrome reveal RNA sequencing RNA-sequencing significantly syndrome T cell T cells was obtained [DOI] 10.1049/syb2.12034 PMC 바로가기 [Article Type] Article