Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M proteinSARS-CoV-2 유전자 ORF8, ORF10 및 M 단백질에 대한 세포 사멸 및 세포 인터페론 및 인터페론 자극 유전자 반응에 대한 칸나비디올의 효과Article Published on 2022-07-152022-09-11 Journal: Life sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] 2′-5′-oligoadenylate synthetase (OAS) family activating acute respiratory syndrome acute respiratory syndrome coronavirus anti-viral response Apoptosis cannabidiol cause Cell cellular Combination component control cell control cells coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 Effect expressing expression HEK293 cell HEK293 cells IFNγ immune responses Innate innate immune response innate immune system Innate immunity interferon interferon-stimulated gene interferons M protein marker membrane protein OAS OAS1 OAS2 OAS3 OASL ORF10 ORF8 Plasmid plasmids Prophylaxis Protein readiness respond response SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 genes severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the SARS-CoV-2 transfected cells transfected with treated Treatment vehicle viral gene viral genes viral infection [DOI] 10.1016/j.lfs.2022.120624 PMC 바로가기 [Article Type] Article
The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in malesTLR3의 다형성 L412F는 자가포식을 억제하고 남성에서 심각한 COVID-19의 표지자입니다Article Published on 2022-07-012022-09-11 Journal: Autophagy [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis association autoantigen autoimmune disorder Autoimmune disorders autophagosome autophagy autophagy pathways bafilomycin clinical trial clinical trials co-morbidity Cohort coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated Diseases Frequency HEK293 cell HEK293 cells HLA HLA haplotype Hydroxychloroquine Impaired increases in Infectious diseases inhibit L412F male males marker mechanism morbidity Necrosis Plasmid poly(I:C) polymorphism provide Rapamycin rationale receiver operating characteristic receptor reduced respiratory risk severe acute respiratory syndrome Coronavirus severe COVID-19 severity shown statistically significant stimulated sub-cohort survival TLR3 TNFα transfected with treated Tumor tumor necrosis tumor necrosis factor [DOI] 10.1080/15548627.2021.1995152 PMC 바로가기 [Article Type] Article
Evaluation of Antibody-Dependent Fc-Mediated Viral Entry, as Compared With Neutralization, in SARS-CoV-2 InfectionSARS-CoV-2 감염에서 중화와 비교한 항체 의존성 Fc 매개 바이러스 진입 평가Article Published on 2022-05-312022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha antibody antibody dependent enhancement B.1.1.7 B.1.351 B.1.617.2 Beta characterization collected concern convalescent plasma coronavirus coronavirus – COVID-19 correlated Delta determine evaluated Fc-mediated virus entry functional Gamma HEK293 cell HEK293 cells IgM in vivo individuals infecting neutralization neutralization activity neutralization potency neutralization titer Neutralizing P.1 pandemic peaked plasma plasma dilution plasma IgG plasmas pseudovirus SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 strain SARS-CoV-2 variants significantly significantly higher significantly lower spike (S) protein titers variant variant of concern viral entry virus virus entry viruses VoC waned Washington while [DOI] 10.3389/fimmu.2022.901217 PMC 바로가기 [Article Type] Article
Development and validation of novel kit for quantification of SARS-CoV-2 antibodies on clinical samples임상 시료의 SARS-CoV-2 항체 정량을 위한 신규 키트 개발 및 검증Article Published on 2022-02-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Accuracy acquisition Antibody testing approved blind chain Chain Reaction Chimera clinical clinical sample clinical samples collected development diagnostic ELISA enzyme exhibited false false-negative false-negative results FDA genetic material gold gold standard HEK293 cell IgG IgG antibodies IgG antibody Immunity immunoassay individuals Infection leads market methodology multiple parameters occurred pandemic Panel parameters patients polymerase chain reaction principle produced quantification reaction reference reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection sensitivity Seroconversion SOOCHAK. specificity surrogate tested Till Virus neutralization WHO [DOI] 10.1016/j.jviromet.2021.114423 PMC 바로가기 [Article Type] Article
Development and preclinical evaluation of virus-like particle vaccine against COVID-19 infectionCOVID-19 감염에 대한 바이러스 유사 입자 백신의 개발 및 전임상 평가Article Published on 2022-01-012022-09-12 Journal: Allergy [Category] SARS, 진단, [키워드] AFM alum anti-N IgG anti-RBD anti-S breadth cellular characterized COVID-19 COVID-19 infection CpG CpG ODN Adjuvant demonstrated development elicited expressing HEK293 cell HEK293 cells humoral immune response Humoral immunity identity immune immunized immunoblotting immunogenic Live virus Lung pathology multifunctional prevented PROTECT Protein protein antigen pulse purified reduced SARS-CoV-2 SARS-CoV-2 antigen SEM structural protein T-cell responses TEM transiently transfected triggered vaccination Vaccine virus load Virus-like particle virus-like particle vaccine VLP VLPs [DOI] 10.1111/all.15091 PMC 바로가기 [Article Type] Article
Inhibition of SARS CoV Envelope Protein by Flavonoids and Classical Viroporin InhibitorsMicrobiology Published on 2021-07-082022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome blocked buffer Cell cell viability assay classical conserved contribute coronavirus E protein Effect effective envelope envelope protein epigallocatechin expressed expression Extracellular family Coronaviridae flavonoid genus Betacoronavirus HEK293 cell inflammasome activation inhibited inhibition inhibitor inhibitors inhibitory activity introduced involved ion channel inhibitors kDa membrane protein novel antiviral drug patch-clamp electrophysiology plasma membrane proliferation Protein quercetin RNA virus SARS CoV SARS CoV-1 SARS-CoV SARS-CoV E SARS-CoV-2 sequence signal peptide single-stranded positive-sense suppress tested transfer transmembrane viability viroporins virus Virus life cycle [DOI] 10.3389/fmicb.2021.692423 PMC 바로가기 [Article Type] Microbiology
Drugs in COVID-19 Clinical Trials: Predicting Transporter-Mediated Drug-Drug Interactions Using In Vitro Assays and Real-World DataCOVID-19 임상 시험의 약물: 체외 분석 및 실제 데이터를 사용하여 운반체 매개 약물-약물 상호작용 예측Article Published on 2021-07-012022-09-11 Journal: Clinical Pharmacology and Therapeutics [Category] SARS, 임상, 치료제, [키워드] accelerated ADRS Adverse drug reaction Adverse drug reactions Chloroquine clinical clinical investigation clinical study clinical trial clinical trials clinically concentrations concomitant medications coronavirus disease Coronavirus disease 2019 COVID-19 criteria database determine drug drug-drug interaction Efficacy Electronic health records expressing Future HEK293 cell HEK293 cells Hydroxychloroquine inhibit membrane vesicle Numerous Older patients with COVID-19 predict predicted real-world data Regulatory Authorities regulatory authority representing risk Risk assessment Sildenafil small molecule small molecule drug target targets Treatment [DOI] 10.1002/cpt.2236 PMC 바로가기 [Article Type] Article
An mRNA-based vaccine candidate against SARS-CoV-2 elicits stable immuno-response with single doseSARS-CoV-2에 대한 mRNA 기반 백신 후보는 단일 용량으로 안정적인 면역 반응을 이끌어냅니다.Article Published on 2021-06-232022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 진단, [키워드] animal model antibody architecture CD4+ cell CD4+ cells characterization clinic coronavirus COVID D614G D614G variant domain dose elicit Extracellular Formulation Genotype HEK293 cell HEK293 cells IgG immunization immunized mice immunologic response immunologic responses implicated Infection Lipid Lipid nanoparticle LNP mRNA-based vaccine neutralized product provide pseudoviruses purified RBD responsible SARS-CoV-2 SARS-CoV-2 virus single dose Spike protein SPR stable population suggested surface plasmon surface plasmon resonance Th1 the spike protein translation vaccination Vaccine vaccine candidate [DOI] 10.1016/j.vaccine.2021.05.035 PMC 바로가기 [Article Type] Article
Antiviral Activity of Two Marine Carotenoids against SARS-CoV-2 Virus Entry In Silico and In VitroArticle Published on 2021-06-172022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 activity angiotensin-converting enzyme 2 antioxidant antiviral activity benefit binding energy carotenoid Codium COVID-19 fucoxanthin Health HEK293 cell IC50 identify information inhibitory activity molecular docking overexpressing pharmacokinetic predicted prevention of COVID-19 SARS-CoV-2 SARS-CoV-2 pseudovirus seaweed siphonaxanthin the SARS-CoV-2 Toxicity Treatment Undaria pinnatifida variety viral infection [DOI] 10.3390/ijms22126481 PMC 바로가기 [Article Type] Article
Purification and characterization of the receptor‐binding domain of SARS‐CoV‐2 spike protein from Escherichia coliResearch Article Published on 2021-05-072022-10-31 Journal: Engineering in Life Sciences [Category] COVID-19, [키워드] ACE2 antigenic epitope binding characterized COVID‐19 COVID‐19 drug E. coli Escherichia coli expected expressed Flow glycosylation HEK293 cell Host host cell inhibitors lack low expression mammalian cell Neutralizing antibodies pandemic Protein protein expression purification purified RBD receptor‐binding domain responsible SARS‐CoV‐2 SARS‐CoV‐2 secondary structure severe respiratory disease spike Spike protein the vaccine Vaccines viral entry virus [DOI] 10.1002/elsc.202000106 PMC 바로가기 [Article Type] Research Article