In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19통합 전사체 프로파일링 접근법을 사용하여 SARS-CoV-2에 대한 인실리코 약물 용도 변경: COVID-19에 대한 잠재적 약물 후보로서 히드로코르티손 및 벤즈히드로코돈Article Published on 2022-09-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ADAR alveolar cell Analysis Anti-viral antiviral immune response Benzhydrocodone binding affinity CASP1 cellular response Cellular responses Clinical studies clinical study complementary COVID-19 COVID-19 pathogenesis determine drug drug candidate Drug repurposing dysregulated enrichment enrichment analysis evaluated FDA-approved drug FOS hallmark HBEGF Host Hydrocortisone ICAM1 identify IFI35 immune system in silico in silico approaches in viral in vitro in vivo experiment infected with SARS-CoV-2 Infectious disease involved IRF2 JUN management MMP9 molecular molecular docking Pathogenesis pathway Pathways promise Protein protein-protein interaction Proteins Repurposed drug Repurposed drugs SARS-CoV-2 SARS-COV-2 infection Signal transduction STAT3 subject suggested transcriptomic transcriptomic profile transcriptomics up-regulated USP18 viral infectious disease [DOI] 10.1016/j.meegid.2022.105318 PMC 바로가기 [Article Type] Article
Reveal the Mechanisms of Yi-Fei-Jian-Pi-Tang on Covid-19 through Network Pharmacology Approach네트워크 약리학 접근법을 통해 Covid-19에 대한 Yi-Fei-Jian-Pi-Tang의 메커니즘 공개Article Published on 2022-07-162022-09-11 Journal: Computational Intelligence and Neuroscience [Category] 유전자 메커니즘, [키워드] activated activator Adhesion Molecule AKT AKT1 Alpha Beta binding C-C motif chemokine ligand C-C motif chemokine ligand 2 cancers CASP8 caspase caspase 8 CCL2 chemokine Chinese contribute Corona Critical CXCL8 Cytoscape database demonstrated effective EGFR enhancer enrichment analysis epidermal epidermal growth factor ERBB2 Formula foundation Gene ontology genomes growth factor Herb HIF1a HMOX1 hypoxia ICAM1 IL10 IL1A IL1B IL2 IL4 IL6 ingredient inhibitor inquiry intercellular intercellular adhesion molecule interferon gamma interleukin interleukin 2 Interleukin 4 interleukin 6 JUN KEGG Kyoto Ligand MAPK3 MAPK8 mechanism Medicine mitogen-activated protein kinase MMP1 MMP3 motif MPO myeloperoxidase Necrosis network network pharmacology NFE2 NFE2L2 NFkB NFKBIA nitric oxide nitric oxide synthase NOS3 nuclear oncogene outcome p53 pathway Pathways Patient Pharmacology PPARA Protein protein kinase protein p53 protein-protein interaction receptor RELA Research Serine Stat1 STRING database subunit target target protein targets TCM TGFB1 therapeutic target threonine Timp1 TNF TP53 Traditional Traditional Chinese medicine Transcription transcription factor transforming growth factor Tumor tumor necrosis tumor necrosis factor tyrosine UniProt Virus Disease [DOI] 10.1155/2022/1493137 PMC 바로가기 [Article Type] Article
The Potential Bioactive Components of Nine TCM Prescriptions Against COVID-19 in Lung Cancer Were Explored Based on Network Pharmacology and Molecular DockingMedicine Published on 2022-01-202022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 ACE2 binding ADRB2 Against Analysis anti-SARS-CoV-2 baicalein China Chinese Chinese medicine component Compound COVID-19 cross database differentially expressed gene enrichment analysis expression FOS Frequency Gene ontology GeneCards highest HMOX1 Hydrogen bond hydrophobic ICAM1 identify IL6 immune immune function immune-related gene immunization ingredient Interaction JUN KEGG Kyoto lung adenocarcinoma molecular docking molecular target National Health Commission network network pharmacology NFKBIA NHC nine objective Occurrence overlapped overlapping performed Pharmacology platform positively correlated Potential potential mechanism prescription Result screened selected Stat1 target target gene TCM TCMSP therapeutic target UniProt viral transcription was used were used with COVID-19 [DOI] 10.3389/fmed.2021.813119 PMC 바로가기 [Article Type] Medicine
Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients With Different SeveritiesImmunology Published on 2022-01-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accompanied addition Analysis Antigen antigen processing B-cell CD14 CD69 CD83 collected Coronavirus disease 2019 COVID-19 CXCR4 dataset datasets dendritic cell dendritic cells disease severity downregulated downregulation exhibited FOS healthy controls HLA HLA class II HLA-DRA HLA-DRB1 IGHV3-21 immune Immune cell immune characteristics immune disorder Immunoglobulin JUN leukocyte memory T memory T cells monocyte mononuclear cell myeloid myeloid cells pathway Patient PBMCs performed Peripheral blood peripheral immune response plasmacytoid dendritic cell progression stage proportion recovered recovered COVID-19 patient Recovered COVID-19 patients recovered patient recovered patients Regulation reported severe symptom single-cell Single-cell RNA sequencing symptom onset T-cell differentiation upregulated upregulation [DOI] 10.3389/fimmu.2021.781432 PMC 바로가기 [Article Type] Immunology
Fos Facilitates Gallid Alpha-Herpesvirus 1 Infection by Transcriptional Control of Host Metabolic Genes and Viral Immediate Early GeneArticle Published on 2021-06-092023-08-29 Journal: Viruses [Category] E형 간염, [키워드] ICP4 FOS Gallid alpha-herpesvirus 1 JUN metabolic genes [DOI] 10.3390/v13061110 PMC 바로가기 [Article Type] Article
Therapeutic targets and signaling mechanisms of vitamin C activity against sepsis: a bioinformatics study패혈증에 대한 비타민 C 활성의 치료 표적 및 신호 메커니즘: 생물정보학 연구Article Published on 2021-05-202022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, [키워드] accumulating addition assays benefit bioinformatics Bioinformatics analysis Biological functions biological processe Clinical practice conducted coronavirus coronavirus disease coronavirus disease-2019 Effect EGFR epidermal epidermal growth factor evidence of functional growth factor hub genes immune immune dysfunction implicated Inflammation involved JUN Kyoto life-threatening MAPK1 mechanism mitogen mitogen-activated protein kinase molecular mechanism molecular mechanisms network pharmacology Pathways Pneumonia Predictive Protein receptor Sepsis shown Signal transducer and activator of transcription Signaling signaling pathway signaling pathways STAT3 suppression target targets treat Treatment Vitamin C [DOI] 10.1093/bib/bbaa079 PMC 바로가기 [Article Type] Article
Network Meta-Analysis on the Mechanisms Underlying Alcohol Augmentation of COVID-19 PathologiesCOVID-19 병리의 알코올 증강의 기본 메커니즘에 대한 네트워크 메타 분석Meta-Analysis Published on 2021-04-012022-08-31 Journal: Alcoholism, clinical and experimental research [Category] MERS, meta-analysis, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affected alcohol alcohol consumption Analysis anti-inflammatory mediator anti-inflammatory mediators augmentation base bioRxiv caused cellular metabolism changes in clinician conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients cytokine Cytokines dataset early phase Effect ENhance Ethanol EtOH Fever fibrosis Gene Expression gene expression profile GEO GEO database glucocorticoid Glucocorticoid receptor hepatic fibrosis HMGB1 homeostasis hyperinflammatory phase IL-1 IL-1β IL-6 IL-6 signaling pathways Inflammation Inflammatory mediators Ingenuity Pathway Analysis Ingenuity Pathway Analysis. inhibiting IPA JUN knowledge base lung mapped mediators Meta-analysis metabolism molecule molecules network Network meta-analysis Neuroinflammation pandemic Pathologies pathway Pathways Patient predicted receptor respiratory retrieved risk RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins sequencing data severe acute respiratory syndrome Coronavirus signaling pathway STAT systemic inflammation TNF transcription factors Viral viral infections worldwide crisis [DOI] 10.1111/acer.14573 PMC 바로가기 [Article Type] Meta-Analysis
Ribosome-Profiling Reveals Restricted Post Transcriptional Expression of Antiviral Cytokines and Transcription Factors during SARS-CoV-2 InfectionArticle Published on 2021-03-252022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] Antiviral Asymptomatic Atf3 Calu-3 caused CCL5 COVID-19 pandemic cytokine Cytokines deaths early phase EGR1 epithelial cell line Factor Genes genotypic change HIVEP2 Host host gene host response human lung IFNB1 IL-6 immune dysregulation Immunity Infection Innate immunity interferon JUN lung mRNA stability outcome post-transcriptional level Regulation Restricted ribosome profiling SARS-CoV-2 SARS-COV-2 infection transcript transcription factor Transcriptome translation translatome Viral load virus ZBTB20 [DOI] 10.3390/ijms22073392 PMC 바로가기 [Article Type] Article
Determining crucial genes associated with COVID-19 based on COPD Findings ✶,✶✶COPD 결과를 기반으로 COVID-19와 관련된 중요 유전자 결정 ✶,✶✶Article Published on 2021-01-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료기술, [키워드] analyzed CCR1 CD40LG cellular COPD COVID-19 COVID-19 virus dataset detect Determining disease FASLG finding function gene network gene networks GeneCard group ICAM1 immune system information IRF7 JUN LIFR MAPK8 MERS MOST NFkB1 NFKBIA organs pathway Patient patients POLD4 respiratory organs RPA2 SARS severe COVID-19 STAT2 susceptible the disease this system virus viruses was used with COVID-19 [DOI] 10.1016/j.compbiomed.2020.104126 PMC 바로가기 [Article Type] Article
Examining the effector mechanisms of Xuebijing injection on COVID-19 based on network pharmacologyResearch Published on 2020-10-162022-10-28 Journal: BioData Mining [Category] COVID-19, [키워드] activated Activation Active ingredient ALB albumin Analysis Anti-inflammatory AutoDock B cell binding activity biological process BPS cascade CASP3 cellular response Chinese component Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease Cytoscape Cytoscape software database demonstrated disease docking score Effect effective Effector mechanism Effects EGFR endothelial enrichment analysis epidermal ESR1 estrogen receptor Examining explain Extracellular GAPDH GeneCard Genes growth factor IL-2 Inflammation ingredient injection International JUN KEGG Kyoto less MAPK MAPK1 MAPK14 MAPK8 mechanism Mild molecular docking Necrosis network pharmacology NF-κB nuclear Ontology participated Pathways pharmacological mechanism PI3K potential mechanism potential therapeutic target PPI predict produced Protein protein-protein interaction provided PTGS2 RAS receptor regulated Regulation renin-angiotensin system Result searched Sepsis severe pneumonia signaling pathway STAT3 SwissTargetPrediction database synergistic T-cell receptor target targets therapeutic effect TLR TNF Toll-like receptor Topology Transcription Treatment TRP VEGF was used Xuebijing [DOI] 10.1186/s13040-020-00227-6 PMC 바로가기 [Article Type] Research